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Gene: SLC2A12 |
Gene summary for SLC2A12 |
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Gene information | Species | Human | Gene symbol | SLC2A12 | Gene ID | 154091 |
Gene name | solute carrier family 2 member 12 | |
Gene Alias | GLUT12 | |
Cytomap | 6q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8TD20 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154091 | SLC2A12 | LZE4T | Human | Esophagus | ESCC | 1.55e-10 | 3.74e-01 | 0.0811 |
154091 | SLC2A12 | LZE7T | Human | Esophagus | ESCC | 1.56e-14 | 7.92e-01 | 0.0667 |
154091 | SLC2A12 | P2T-E | Human | Esophagus | ESCC | 1.05e-23 | 4.19e-01 | 0.1177 |
154091 | SLC2A12 | P4T-E | Human | Esophagus | ESCC | 3.78e-04 | 1.29e-01 | 0.1323 |
154091 | SLC2A12 | P8T-E | Human | Esophagus | ESCC | 8.96e-04 | 7.87e-02 | 0.0889 |
154091 | SLC2A12 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.16e-01 | 0.1426 |
154091 | SLC2A12 | P12T-E | Human | Esophagus | ESCC | 1.25e-05 | 1.79e-01 | 0.1122 |
154091 | SLC2A12 | P15T-E | Human | Esophagus | ESCC | 1.31e-02 | 9.83e-02 | 0.1149 |
154091 | SLC2A12 | P16T-E | Human | Esophagus | ESCC | 4.12e-05 | 9.71e-02 | 0.1153 |
154091 | SLC2A12 | P23T-E | Human | Esophagus | ESCC | 7.24e-11 | 3.04e-01 | 0.108 |
154091 | SLC2A12 | P26T-E | Human | Esophagus | ESCC | 4.65e-12 | 3.73e-01 | 0.1276 |
154091 | SLC2A12 | P27T-E | Human | Esophagus | ESCC | 7.56e-15 | 3.09e-01 | 0.1055 |
154091 | SLC2A12 | P30T-E | Human | Esophagus | ESCC | 4.44e-04 | 2.22e-01 | 0.137 |
154091 | SLC2A12 | P37T-E | Human | Esophagus | ESCC | 2.31e-05 | 1.48e-01 | 0.1371 |
154091 | SLC2A12 | P39T-E | Human | Esophagus | ESCC | 1.50e-17 | 3.93e-01 | 0.0894 |
154091 | SLC2A12 | P40T-E | Human | Esophagus | ESCC | 4.53e-04 | 1.45e-01 | 0.109 |
154091 | SLC2A12 | P48T-E | Human | Esophagus | ESCC | 7.52e-08 | 1.87e-01 | 0.0959 |
154091 | SLC2A12 | P52T-E | Human | Esophagus | ESCC | 1.19e-03 | 1.61e-01 | 0.1555 |
154091 | SLC2A12 | P56T-E | Human | Esophagus | ESCC | 1.10e-03 | 4.08e-01 | 0.1613 |
154091 | SLC2A12 | P61T-E | Human | Esophagus | ESCC | 1.02e-05 | 1.72e-01 | 0.099 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC2A12 | SNV | Missense_Mutation | rs779184200 | c.808C>T | p.Arg270Cys | p.R270C | Q8TD20 | protein_coding | deleterious(0.04) | benign(0.127) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SLC2A12 | SNV | Missense_Mutation | novel | c.1421C>T | p.Ala474Val | p.A474V | Q8TD20 | protein_coding | deleterious(0) | possibly_damaging(0.688) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC2A12 | SNV | Missense_Mutation | c.1557N>T | p.Leu519Phe | p.L519F | Q8TD20 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
SLC2A12 | insertion | Nonsense_Mutation | novel | c.421_422insCAAGGTTCTTGGAAGGTTAAGAGCACTCTCAGATACAACTGA | p.Gly141delinsAlaArgPheLeuGluGlyTerGluHisSerGlnIleGlnLeuArg | p.G141delinsARFLEG*EHSQIQLR | Q8TD20 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
SLC2A12 | insertion | Frame_Shift_Ins | novel | c.275_276insATGCATCAACTGTTTTGAAGTCAGTTGGATTTCAAAGC | p.Ala93CysfsTer21 | p.A93Cfs*21 | Q8TD20 | protein_coding | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
SLC2A12 | deletion | Frame_Shift_Del | novel | c.174_184delTGGGATCATCT | p.Gly59TrpfsTer16 | p.G59Wfs*16 | Q8TD20 | protein_coding | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SLC2A12 | insertion | Nonsense_Mutation | novel | c.1098_1099insCCTTGAGCTG | p.Asn367ProfsTer2 | p.N367Pfs*2 | Q8TD20 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
SLC2A12 | insertion | Frame_Shift_Ins | novel | c.1610_1611insT | p.Met537IlefsTer15 | p.M537Ifs*15 | Q8TD20 | protein_coding | TCGA-E9-A24A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SLC2A12 | SNV | Missense_Mutation | c.471N>T | p.Glu157Asp | p.E157D | Q8TD20 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SLC2A12 | SNV | Missense_Mutation | c.670N>A | p.Leu224Met | p.L224M | Q8TD20 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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