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Gene: SLC29A2 |
Gene summary for SLC29A2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SLC29A2 | Gene ID | 3177 |
| Gene name | solute carrier family 29 member 2 | |
| Gene Alias | DER12 | |
| Cytomap | 11q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0001504 | UniProtAcc | Q14542 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3177 | SLC29A2 | LZE24T | Human | Esophagus | ESCC | 5.13e-07 | 1.10e-01 | 0.0596 |
| 3177 | SLC29A2 | P2T-E | Human | Esophagus | ESCC | 1.58e-06 | 1.74e-01 | 0.1177 |
| 3177 | SLC29A2 | P4T-E | Human | Esophagus | ESCC | 2.67e-17 | 4.10e-01 | 0.1323 |
| 3177 | SLC29A2 | P5T-E | Human | Esophagus | ESCC | 8.68e-30 | 5.63e-01 | 0.1327 |
| 3177 | SLC29A2 | P8T-E | Human | Esophagus | ESCC | 2.14e-06 | 1.31e-01 | 0.0889 |
| 3177 | SLC29A2 | P12T-E | Human | Esophagus | ESCC | 4.79e-04 | 1.28e-01 | 0.1122 |
| 3177 | SLC29A2 | P15T-E | Human | Esophagus | ESCC | 1.54e-16 | 3.80e-01 | 0.1149 |
| 3177 | SLC29A2 | P16T-E | Human | Esophagus | ESCC | 2.53e-03 | 1.53e-01 | 0.1153 |
| 3177 | SLC29A2 | P23T-E | Human | Esophagus | ESCC | 1.77e-09 | 2.32e-01 | 0.108 |
| 3177 | SLC29A2 | P24T-E | Human | Esophagus | ESCC | 9.56e-06 | 1.22e-01 | 0.1287 |
| 3177 | SLC29A2 | P26T-E | Human | Esophagus | ESCC | 1.76e-04 | 1.54e-01 | 0.1276 |
| 3177 | SLC29A2 | P28T-E | Human | Esophagus | ESCC | 3.40e-22 | 5.57e-01 | 0.1149 |
| 3177 | SLC29A2 | P30T-E | Human | Esophagus | ESCC | 9.53e-03 | 1.08e-01 | 0.137 |
| 3177 | SLC29A2 | P37T-E | Human | Esophagus | ESCC | 1.35e-07 | 2.17e-01 | 0.1371 |
| 3177 | SLC29A2 | P47T-E | Human | Esophagus | ESCC | 1.26e-02 | 7.88e-02 | 0.1067 |
| 3177 | SLC29A2 | P49T-E | Human | Esophagus | ESCC | 2.64e-05 | 4.80e-01 | 0.1768 |
| 3177 | SLC29A2 | P52T-E | Human | Esophagus | ESCC | 9.58e-05 | 1.74e-01 | 0.1555 |
| 3177 | SLC29A2 | P54T-E | Human | Esophagus | ESCC | 3.37e-06 | 2.00e-01 | 0.0975 |
| 3177 | SLC29A2 | P56T-E | Human | Esophagus | ESCC | 2.80e-04 | 6.27e-01 | 0.1613 |
| 3177 | SLC29A2 | P57T-E | Human | Esophagus | ESCC | 7.62e-06 | 1.75e-01 | 0.0926 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SLC29A2 | SNV | Missense_Mutation | c.496N>A | p.Gly166Ser | p.G166S | Q14542 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SLC29A2 | SNV | Missense_Mutation | rs140572979 | c.1361N>T | p.Ala454Val | p.A454V | Q14542 | protein_coding | tolerated(0.13) | benign(0.424) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC29A2 | SNV | Missense_Mutation | c.530C>A | p.Ala177Asp | p.A177D | Q14542 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SLC29A2 | SNV | Missense_Mutation | rs771598411 | c.881C>T | p.Ala294Val | p.A294V | Q14542 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC29A2 | SNV | Missense_Mutation | c.502N>T | p.Gly168Cys | p.G168C | Q14542 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SLC29A2 | SNV | Missense_Mutation | novel | c.314N>T | p.Ala105Val | p.A105V | Q14542 | protein_coding | tolerated(0.92) | benign(0) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| SLC29A2 | SNV | Missense_Mutation | c.508G>A | p.Ala170Thr | p.A170T | Q14542 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| SLC29A2 | SNV | Missense_Mutation | c.1291N>T | p.Gly431Cys | p.G431C | Q14542 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| SLC29A2 | SNV | Missense_Mutation | rs774663200 | c.1294G>A | p.Ala432Thr | p.A432T | Q14542 | protein_coding | tolerated(0.19) | benign(0.03) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SLC29A2 | SNV | Missense_Mutation | novel | c.151G>A | p.Ala51Thr | p.A51T | Q14542 | protein_coding | tolerated(0.65) | benign(0) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 3177 | SLC29A2 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | gemcitabine | GEMCITABINE | 25162786 | |
| 3177 | SLC29A2 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | TECADENOSON | TECADENOSON | 23388705 | |
| 3177 | SLC29A2 | DRUGGABLE GENOME, TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE | 6-MERCAPTOPURINE | MERCAPTOPURINE | 17088032 |
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