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Gene: SLC16A8 |
Gene summary for SLC16A8 |
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Gene information | Species | Human | Gene symbol | SLC16A8 | Gene ID | 23539 |
Gene name | solute carrier family 16 member 8 | |
Gene Alias | MCT3 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O95907 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23539 | SLC16A8 | P10T-E | Human | Esophagus | ESCC | 1.31e-30 | 5.90e-01 | 0.116 |
23539 | SLC16A8 | P31T-E | Human | Esophagus | ESCC | 8.16e-06 | 1.75e-01 | 0.1251 |
23539 | SLC16A8 | P74T-E | Human | Esophagus | ESCC | 3.84e-17 | 4.25e-01 | 0.1479 |
23539 | SLC16A8 | P130T-E | Human | Esophagus | ESCC | 5.61e-31 | 5.85e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC16A8 | SNV | Missense_Mutation | c.242G>A | p.Arg81His | p.R81H | O95907 | protein_coding | deleterious(0.01) | possibly_damaging(0.459) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC16A8 | SNV | Missense_Mutation | rs748310060 | c.1454G>A | p.Arg485Gln | p.R485Q | O95907 | protein_coding | tolerated(0.83) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
SLC16A8 | SNV | Missense_Mutation | c.1021N>T | p.Arg341Cys | p.R341C | O95907 | protein_coding | deleterious(0.04) | probably_damaging(0.953) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
SLC16A8 | SNV | Missense_Mutation | c.1450N>A | p.Ala484Thr | p.A484T | O95907 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SLC16A8 | SNV | Missense_Mutation | novel | c.1400N>A | p.Pro467His | p.P467H | O95907 | protein_coding | deleterious(0.04) | probably_damaging(0.921) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SLC16A8 | SNV | Missense_Mutation | novel | c.314C>T | p.Ala105Val | p.A105V | O95907 | protein_coding | deleterious(0.02) | benign(0.42) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC16A8 | SNV | Missense_Mutation | novel | c.1363N>A | p.Glu455Lys | p.E455K | O95907 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SLC16A8 | SNV | Missense_Mutation | novel | c.149T>C | p.Phe50Ser | p.F50S | O95907 | protein_coding | deleterious(0) | possibly_damaging(0.626) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SLC16A8 | SNV | Missense_Mutation | rs572012866 | c.1201C>T | p.Arg401Cys | p.R401C | O95907 | protein_coding | deleterious(0.03) | possibly_damaging(0.872) | TCGA-EJ-7315-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
SLC16A8 | SNV | Missense_Mutation | c.1450G>A | p.Ala484Thr | p.A484T | O95907 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-CG-4436-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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