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Gene: SIX5 |
Gene summary for SIX5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SIX5 | Gene ID | 147912 |
Gene name | SIX homeobox 5 | |
Gene Alias | BOR2 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8N196 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147912 | SIX5 | LZE24T | Human | Esophagus | ESCC | 3.48e-02 | 1.16e-01 | 0.0596 |
147912 | SIX5 | P1T-E | Human | Esophagus | ESCC | 4.01e-05 | 2.58e-01 | 0.0875 |
147912 | SIX5 | P2T-E | Human | Esophagus | ESCC | 5.54e-13 | 1.97e-01 | 0.1177 |
147912 | SIX5 | P4T-E | Human | Esophagus | ESCC | 9.77e-05 | 7.52e-02 | 0.1323 |
147912 | SIX5 | P5T-E | Human | Esophagus | ESCC | 1.31e-04 | 1.11e-01 | 0.1327 |
147912 | SIX5 | P8T-E | Human | Esophagus | ESCC | 5.11e-14 | 2.60e-01 | 0.0889 |
147912 | SIX5 | P9T-E | Human | Esophagus | ESCC | 1.01e-03 | 1.30e-01 | 0.1131 |
147912 | SIX5 | P10T-E | Human | Esophagus | ESCC | 4.59e-08 | 2.09e-01 | 0.116 |
147912 | SIX5 | P11T-E | Human | Esophagus | ESCC | 2.36e-05 | 2.18e-01 | 0.1426 |
147912 | SIX5 | P12T-E | Human | Esophagus | ESCC | 7.65e-09 | 1.41e-01 | 0.1122 |
147912 | SIX5 | P15T-E | Human | Esophagus | ESCC | 1.01e-13 | 1.44e-01 | 0.1149 |
147912 | SIX5 | P16T-E | Human | Esophagus | ESCC | 5.31e-09 | 1.76e-01 | 0.1153 |
147912 | SIX5 | P17T-E | Human | Esophagus | ESCC | 3.59e-03 | 1.87e-01 | 0.1278 |
147912 | SIX5 | P19T-E | Human | Esophagus | ESCC | 4.43e-03 | 2.63e-01 | 0.1662 |
147912 | SIX5 | P20T-E | Human | Esophagus | ESCC | 1.45e-06 | 1.52e-01 | 0.1124 |
147912 | SIX5 | P21T-E | Human | Esophagus | ESCC | 2.56e-09 | 1.78e-01 | 0.1617 |
147912 | SIX5 | P22T-E | Human | Esophagus | ESCC | 1.96e-08 | 1.46e-01 | 0.1236 |
147912 | SIX5 | P23T-E | Human | Esophagus | ESCC | 3.34e-07 | 1.88e-01 | 0.108 |
147912 | SIX5 | P24T-E | Human | Esophagus | ESCC | 1.02e-03 | 1.00e-01 | 0.1287 |
147912 | SIX5 | P27T-E | Human | Esophagus | ESCC | 7.63e-06 | 1.04e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:00330024 | Oral cavity | OSCC | muscle cell proliferation | 115/7305 | 248/18723 | 1.05e-02 | 3.58e-02 | 115 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIX5 | SNV | Missense_Mutation | rs561325897 | c.947C>T | p.Pro316Leu | p.P316L | Q8N196 | protein_coding | tolerated(0.35) | benign(0.074) | TCGA-C5-A3HF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SIX5 | SNV | Missense_Mutation | c.758G>C | p.Arg253Pro | p.R253P | Q8N196 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SIX5 | SNV | Missense_Mutation | c.845N>A | p.Arg282Gln | p.R282Q | Q8N196 | protein_coding | tolerated(0.1) | benign(0.17) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SIX5 | SNV | Missense_Mutation | c.499N>A | p.Ala167Thr | p.A167T | Q8N196 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SIX5 | SNV | Missense_Mutation | novel | c.1054G>C | p.Glu352Gln | p.E352Q | Q8N196 | protein_coding | tolerated(0.25) | probably_damaging(0.953) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SIX5 | SNV | Missense_Mutation | novel | c.1789G>C | p.Glu597Gln | p.E597Q | Q8N196 | protein_coding | deleterious(0.01) | benign(0.188) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SIX5 | SNV | Missense_Mutation | c.1018N>A | p.Gly340Arg | p.G340R | Q8N196 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIX5 | SNV | Missense_Mutation | c.914N>C | p.Phe305Ser | p.F305S | Q8N196 | protein_coding | tolerated(0.1) | benign(0.206) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIX5 | SNV | Missense_Mutation | c.1343N>C | p.Val448Ala | p.V448A | Q8N196 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SIX5 | SNV | Missense_Mutation | c.674N>G | p.Tyr225Cys | p.Y225C | Q8N196 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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