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Gene: SIRT6 |
Gene summary for SIRT6 |
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Gene information | Species | Human | Gene symbol | SIRT6 | Gene ID | 51548 |
Gene name | sirtuin 6 | |
Gene Alias | SIR2L6 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q8N6T7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51548 | SIRT6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.24e-14 | 5.57e-01 | -0.1808 |
51548 | SIRT6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.52e-03 | 3.31e-01 | -0.1207 |
51548 | SIRT6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.78e-04 | 3.44e-01 | -0.1464 |
51548 | SIRT6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.60e-02 | 2.35e-01 | -0.059 |
51548 | SIRT6 | LZE4T | Human | Esophagus | ESCC | 3.93e-05 | 1.43e-01 | 0.0811 |
51548 | SIRT6 | LZE7T | Human | Esophagus | ESCC | 1.32e-06 | 3.05e-01 | 0.0667 |
51548 | SIRT6 | LZE8T | Human | Esophagus | ESCC | 1.29e-04 | 1.82e-01 | 0.067 |
51548 | SIRT6 | LZE20T | Human | Esophagus | ESCC | 4.56e-08 | 1.46e-01 | 0.0662 |
51548 | SIRT6 | LZE22T | Human | Esophagus | ESCC | 3.34e-02 | 2.51e-01 | 0.068 |
51548 | SIRT6 | LZE24T | Human | Esophagus | ESCC | 7.12e-09 | 2.23e-01 | 0.0596 |
51548 | SIRT6 | LZE21T | Human | Esophagus | ESCC | 1.34e-04 | 2.25e-01 | 0.0655 |
51548 | SIRT6 | LZE6T | Human | Esophagus | ESCC | 5.08e-05 | 2.52e-01 | 0.0845 |
51548 | SIRT6 | P1T-E | Human | Esophagus | ESCC | 5.05e-08 | 2.48e-01 | 0.0875 |
51548 | SIRT6 | P2T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.52e-01 | 0.1177 |
51548 | SIRT6 | P4T-E | Human | Esophagus | ESCC | 1.37e-18 | 3.52e-01 | 0.1323 |
51548 | SIRT6 | P5T-E | Human | Esophagus | ESCC | 1.13e-08 | 1.87e-01 | 0.1327 |
51548 | SIRT6 | P8T-E | Human | Esophagus | ESCC | 2.28e-35 | 5.94e-01 | 0.0889 |
51548 | SIRT6 | P9T-E | Human | Esophagus | ESCC | 8.65e-21 | 3.56e-01 | 0.1131 |
51548 | SIRT6 | P10T-E | Human | Esophagus | ESCC | 1.01e-32 | 4.74e-01 | 0.116 |
51548 | SIRT6 | P11T-E | Human | Esophagus | ESCC | 4.89e-11 | 3.99e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:1903050 | Colorectum | AD | regulation of proteolysis involved in cellular protein catabolic process | 92/3918 | 221/18723 | 2.04e-12 | 3.19e-10 | 92 |
GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0061136 | Colorectum | AD | regulation of proteasomal protein catabolic process | 75/3918 | 187/18723 | 1.65e-09 | 1.20e-07 | 75 |
GO:2000058 | Colorectum | AD | regulation of ubiquitin-dependent protein catabolic process | 68/3918 | 164/18723 | 1.82e-09 | 1.31e-07 | 68 |
GO:1903364 | Colorectum | AD | positive regulation of cellular protein catabolic process | 62/3918 | 155/18723 | 4.66e-08 | 2.51e-06 | 62 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0032434 | Colorectum | AD | regulation of proteasomal ubiquitin-dependent protein catabolic process | 54/3918 | 134/18723 | 2.51e-07 | 1.02e-05 | 54 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:1903052 | Colorectum | AD | positive regulation of proteolysis involved in cellular protein catabolic process | 53/3918 | 133/18723 | 4.93e-07 | 1.85e-05 | 53 |
GO:2000060 | Colorectum | AD | positive regulation of ubiquitin-dependent protein catabolic process | 44/3918 | 107/18723 | 1.65e-06 | 5.03e-05 | 44 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
GO:1901800 | Colorectum | AD | positive regulation of proteasomal protein catabolic process | 44/3918 | 114/18723 | 1.18e-05 | 2.62e-04 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa052302 | Colorectum | SER | Central carbon metabolism in cancer | 25/1580 | 70/8465 | 5.43e-04 | 4.51e-03 | 3.27e-03 | 25 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa052303 | Colorectum | SER | Central carbon metabolism in cancer | 25/1580 | 70/8465 | 5.43e-04 | 4.51e-03 | 3.27e-03 | 25 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0523018 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0523019 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa0471430 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa0523016 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa04714113 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa0523017 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIRT6 | SNV | Missense_Mutation | rs540970217 | c.583C>T | p.Arg195Trp | p.R195W | Q8N6T7 | protein_coding | deleterious(0) | benign(0.344) | TCGA-BH-A203-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SIRT6 | deletion | Frame_Shift_Del | novel | c.193delN | p.Arg65GlyfsTer95 | p.R65Gfs*95 | Q8N6T7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SIRT6 | deletion | Frame_Shift_Del | c.671delN | p.Asn224ThrfsTer39 | p.N224Tfs*39 | Q8N6T7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
SIRT6 | SNV | Missense_Mutation | c.787N>C | p.Thr263Pro | p.T263P | Q8N6T7 | protein_coding | tolerated(0.09) | benign(0.046) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
SIRT6 | SNV | Missense_Mutation | c.956N>T | p.Pro319Leu | p.P319L | Q8N6T7 | protein_coding | deleterious(0) | benign(0.133) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SIRT6 | SNV | Missense_Mutation | c.806N>A | p.Leu269Gln | p.L269Q | Q8N6T7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SIRT6 | SNV | Missense_Mutation | c.94N>T | p.Arg32Trp | p.R32W | Q8N6T7 | protein_coding | deleterious(0.02) | possibly_damaging(0.466) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIRT6 | SNV | Missense_Mutation | novel | c.908N>A | p.Ser303Tyr | p.S303Y | Q8N6T7 | protein_coding | tolerated(0.05) | benign(0.085) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT6 | SNV | Missense_Mutation | novel | c.1055N>T | p.Ala352Val | p.A352V | Q8N6T7 | protein_coding | tolerated_low_confidence(0.33) | benign(0) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT6 | SNV | Missense_Mutation | novel | c.653N>G | p.Gln218Arg | p.Q218R | Q8N6T7 | protein_coding | deleterious(0) | benign(0.327) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51548 | SIRT6 | TRANSCRIPTION FACTOR, ENZYME | inhibitor | 252827474 | ||
51548 | SIRT6 | TRANSCRIPTION FACTOR, ENZYME | allosteric modulator | 381118833 |
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