Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SINHCAF

Gene summary for SINHCAF

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SINHCAF

Gene ID

58516

Gene nameSIN3-HDAC complex associated factor
Gene AliasC12orf14
Cytomap12p11.21
Gene Typeprotein-coding
GO ID

GO:0006928

UniProtAcc

Q9NP50


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
58516SINHCAFHTA11_3410_2000001011HumanColorectumAD6.68e-03-2.94e-010.0155
58516SINHCAFHTA11_696_2000001011HumanColorectumAD3.40e-03-2.73e-01-0.1464
58516SINHCAFHTA11_866_3004761011HumanColorectumAD1.57e-02-3.42e-010.096
58516SINHCAFHTA11_7696_3000711011HumanColorectumAD2.69e-02-2.66e-010.0674
58516SINHCAFHTA11_99999970781_79442HumanColorectumMSS6.56e-26-5.31e-010.294
58516SINHCAFHTA11_99999965104_69814HumanColorectumMSS6.29e-10-5.31e-010.281
58516SINHCAFHTA11_99999971662_82457HumanColorectumMSS7.76e-28-5.31e-010.3859
58516SINHCAFHTA11_99999973899_84307HumanColorectumMSS2.25e-07-5.31e-010.2585
58516SINHCAFHTA11_99999974143_84620HumanColorectumMSS1.58e-25-5.31e-010.3005
58516SINHCAFA015-C-203HumanColorectumFAP6.68e-15-3.76e-01-0.1294
58516SINHCAFA015-C-204HumanColorectumFAP1.22e-04-2.75e-01-0.0228
58516SINHCAFA014-C-040HumanColorectumFAP4.96e-02-3.98e-01-0.1184
58516SINHCAFA002-C-201HumanColorectumFAP2.38e-08-2.69e-010.0324
58516SINHCAFA001-C-119HumanColorectumFAP1.29e-06-3.70e-01-0.1557
58516SINHCAFA001-C-108HumanColorectumFAP1.61e-05-2.43e-01-0.0272
58516SINHCAFA002-C-205HumanColorectumFAP3.33e-12-2.92e-01-0.1236
58516SINHCAFA015-C-005HumanColorectumFAP3.59e-02-2.11e-01-0.0336
58516SINHCAFA015-C-006HumanColorectumFAP1.50e-07-2.22e-01-0.0994
58516SINHCAFA015-C-106HumanColorectumFAP1.14e-05-2.50e-01-0.0511
58516SINHCAFA002-C-114HumanColorectumFAP5.21e-11-3.38e-01-0.1561
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00303364EndometriumAEHnegative regulation of cell migration65/2100344/187231.65e-053.42e-0465
GO:20001464EndometriumAEHnegative regulation of cell motility67/2100359/187231.86e-053.77e-0467
GO:00512714EndometriumAEHnegative regulation of cellular component movement68/2100367/187232.06e-054.11e-0468
GO:00400134EndometriumAEHnegative regulation of locomotion70/2100391/187234.95e-058.05e-0470
GO:200014613EndometriumEECnegative regulation of cell motility71/2168359/187233.98e-061.04e-0471
GO:005127113EndometriumEECnegative regulation of cellular component movement72/2168367/187234.59e-061.15e-0472
GO:003033612EndometriumEECnegative regulation of cell migration67/2168344/187231.24e-052.54e-0467
GO:004001312EndometriumEECnegative regulation of locomotion74/2168391/187231.28e-052.59e-0474
GO:00512715ProstateBPHnegative regulation of cellular component movement94/3107367/187236.18e-069.00e-0594
GO:20001465ProstateBPHnegative regulation of cell motility91/3107359/187231.34e-051.76e-0491
GO:00400135ProstateBPHnegative regulation of locomotion96/3107391/187233.11e-053.54e-0496
GO:00303365ProstateBPHnegative regulation of cell migration86/3107344/187233.93e-054.25e-0486
GO:005127114ProstateTumornegative regulation of cellular component movement92/3246367/187231.03e-049.99e-0492
GO:200014614ProstateTumornegative regulation of cell motility89/3246359/187231.99e-041.74e-0389
GO:004001313ProstateTumornegative regulation of locomotion94/3246391/187234.20e-043.21e-0394
GO:003033613ProstateTumornegative regulation of cell migration84/3246344/187234.95e-043.66e-0384
GO:00512717SkinAKnegative regulation of cellular component movement59/1910367/187232.85e-042.99e-0359
GO:00400137SkinAKnegative regulation of locomotion62/1910391/187232.96e-043.08e-0362
GO:20001467SkinAKnegative regulation of cell motility57/1910359/187234.91e-044.55e-0357
GO:00303367SkinAKnegative regulation of cell migration53/1910344/187231.52e-031.10e-0253
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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