Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SIN3A

Gene summary for SIN3A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SIN3A

Gene ID

25942

Gene nameSIN3 transcription regulator family member A
Gene AliasWITKOS
Cytomap15q24.2
Gene Typeprotein-coding
GO ID

GO:0000086

UniProtAcc

Q96ST3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
25942SIN3ACCI_1HumanCervixCC1.02e-025.68e-010.528
25942SIN3ACCI_2HumanCervixCC1.25e-036.75e-010.5249
25942SIN3ACCI_3HumanCervixCC2.05e-065.46e-010.516
25942SIN3ALZE2THumanEsophagusESCC2.93e-048.12e-010.082
25942SIN3ALZE4THumanEsophagusESCC1.10e-124.00e-010.0811
25942SIN3ALZE5THumanEsophagusESCC3.53e-022.35e-010.0514
25942SIN3ALZE7THumanEsophagusESCC4.83e-155.71e-010.0667
25942SIN3ALZE22THumanEsophagusESCC8.78e-032.87e-010.068
25942SIN3ALZE24THumanEsophagusESCC1.45e-121.89e-010.0596
25942SIN3ALZE21THumanEsophagusESCC3.61e-042.54e-010.0655
25942SIN3AP1T-EHumanEsophagusESCC6.18e-105.02e-010.0875
25942SIN3AP2T-EHumanEsophagusESCC9.54e-194.20e-010.1177
25942SIN3AP4T-EHumanEsophagusESCC1.68e-123.06e-010.1323
25942SIN3AP5T-EHumanEsophagusESCC5.53e-072.78e-020.1327
25942SIN3AP8T-EHumanEsophagusESCC9.75e-203.41e-010.0889
25942SIN3AP9T-EHumanEsophagusESCC7.01e-153.83e-010.1131
25942SIN3AP10T-EHumanEsophagusESCC1.48e-172.46e-010.116
25942SIN3AP11T-EHumanEsophagusESCC1.40e-061.41e-010.1426
25942SIN3AP12T-EHumanEsophagusESCC2.50e-193.74e-010.1122
25942SIN3AP15T-EHumanEsophagusESCC7.27e-245.60e-010.1149
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000697910CervixCCresponse to oxidative stress102/2311446/187232.99e-104.36e-08102
GO:00321035CervixCCpositive regulation of response to external stimulus95/2311427/187235.44e-095.03e-0795
GO:004361810CervixCCregulation of transcription from RNA polymerase II promoter in response to stress21/231147/187233.85e-082.53e-0621
GO:004362010CervixCCregulation of DNA-templated transcription in response to stress22/231153/187239.29e-085.19e-0622
GO:00345048CervixCCprotein localization to nucleus68/2311290/187239.91e-085.25e-0668
GO:006219710CervixCCcellular response to chemical stress76/2311337/187231.01e-075.25e-0676
GO:005109810CervixCCregulation of binding80/2311363/187231.32e-076.42e-0680
GO:00447725CervixCCmitotic cell cycle phase transition89/2311424/187232.70e-071.12e-0589
GO:00075689CervixCCaging75/2311339/187232.75e-071.13e-0575
GO:00485118CervixCCrhythmic process65/2311298/187232.79e-068.04e-0565
GO:003459910CervixCCcellular response to oxidative stress63/2311288/187233.58e-069.50e-0563
GO:00457876CervixCCpositive regulation of cell cycle66/2311313/187237.78e-061.81e-0466
GO:00313494CervixCCpositive regulation of defense response60/2311278/187239.38e-062.11e-0460
GO:00160498CervixCCcell growth92/2311482/187231.16e-052.49e-0492
GO:00073466CervixCCregulation of mitotic cell cycle88/2311457/187231.26e-052.60e-0488
GO:19019903CervixCCregulation of mitotic cell cycle phase transition63/2311299/187231.27e-052.60e-0463
GO:00325359CervixCCregulation of cellular component size76/2311383/187231.66e-053.21e-0476
GO:00615647CervixCCaxon development89/2311467/187231.71e-053.27e-0489
GO:00028315CervixCCregulation of response to biotic stimulus67/2311327/187231.79e-053.36e-0467
GO:190165410CervixCCresponse to ketone45/2311194/187231.83e-053.44e-0445
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501618CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0516920CervixCCEpstein-Barr virus infection57/1267202/84657.30e-077.39e-064.37e-0657
hsa0491918CervixCCThyroid hormone signaling pathway33/1267121/84653.11e-041.65e-039.78e-0433
hsa0501619CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa05169110CervixCCEpstein-Barr virus infection57/1267202/84657.30e-077.39e-064.37e-0657
hsa0491919CervixCCThyroid hormone signaling pathway33/1267121/84653.11e-041.65e-039.78e-0433
hsa05016210EsophagusESCCHuntington disease226/4205306/84651.38e-188.72e-174.46e-17226
hsa05169210EsophagusESCCEpstein-Barr virus infection151/4205202/84651.55e-133.45e-121.77e-12151
hsa0491928EsophagusESCCThyroid hormone signaling pathway78/4205121/84656.79e-042.23e-031.14e-0378
hsa043507EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0501638EsophagusESCCHuntington disease226/4205306/84651.38e-188.72e-174.46e-17226
hsa0516937EsophagusESCCEpstein-Barr virus infection151/4205202/84651.55e-133.45e-121.77e-12151
hsa04919113EsophagusESCCThyroid hormone signaling pathway78/4205121/84656.79e-042.23e-031.14e-0378
hsa0435014EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa0520213EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0501614LiverCirrhoticHuntington disease172/2530306/84651.65e-221.10e-206.77e-21172
hsa0516914LiverCirrhoticEpstein-Barr virus infection80/2530202/84651.80e-038.33e-035.13e-0380
hsa0501615LiverCirrhoticHuntington disease172/2530306/84651.65e-221.10e-206.77e-21172
hsa0516915LiverCirrhoticEpstein-Barr virus infection80/2530202/84651.80e-038.33e-035.13e-0380
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
SIN3ACD8TCMColorectumMSI-HZNRF1,KIF3A,STN1, etc.2.16e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ABMEMEsophagusADJCLCN5,FAM160A1,LY6G5C, etc.3.46e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ABMEMEsophagusESCCCLCN5,FAM160A1,LY6G5C, etc.1.79e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ACD8TEXINTEsophagusESCCCLCN5,FAM160A1,LY6G5C, etc.1.53e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ASTMProstateBPHSH3RF3,C2orf42,DNM3, etc.2.77e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ABASSkinADJZNF711,INTS6L,NSUN6, etc.1.85e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ABASSkinSCCISZNF711,INTS6L,NSUN6, etc.1.89e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3ASTMStomachHealthyTNIP1,HMG20B,PDLIM3, etc.2.02e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SIN3AGMCStomachHealthyTNIP1,HMG20B,PDLIM3, etc.2.39e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SIN3ASNVMissense_Mutationc.2453N>Gp.His818Argp.H818RQ96ST3protein_codingtolerated(0.12)benign(0.298)TCGA-A2-A0YG-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
SIN3ASNVMissense_Mutationc.3331N>Gp.Thr1111Alap.T1111AQ96ST3protein_codingtolerated(1)benign(0.003)TCGA-AC-A3HN-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SIN3ASNVMissense_Mutationc.1441G>Ap.Glu481Lysp.E481KQ96ST3protein_codingdeleterious(0)possibly_damaging(0.732)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SIN3ASNVMissense_Mutationc.1898N>Cp.Leu633Prop.L633PQ96ST3protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AO-A03O-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydoxorubicinSD
SIN3ASNVMissense_Mutationnovelc.3604N>Ap.Val1202Ilep.V1202IQ96ST3protein_codingtolerated(0.11)probably_damaging(0.927)TCGA-BH-A0B6-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SIN3ASNVMissense_Mutationc.916N>Tp.His306Tyrp.H306YQ96ST3protein_codingdeleterious(0)probably_damaging(0.953)TCGA-D8-A1JA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
SIN3ASNVMissense_Mutationnovelc.3626N>Ap.Arg1209Lysp.R1209KQ96ST3protein_codingtolerated(0.58)benign(0.109)TCGA-E9-A5FL-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SIN3AinsertionNonsense_Mutationnovelc.2657_2658insTTAAACAAAAGGACTTTGACAAATGCAGATTACTTCAp.Tyr887Terp.Y887*Q96ST3protein_codingTCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
SIN3AinsertionNonsense_Mutationnovelc.1810_1811insCTGCCTCAGCCTCTTGAGTp.Gln604ProfsTer6p.Q604Pfs*6Q96ST3protein_codingTCGA-AO-A0J5-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonatezoledronicPD
SIN3AinsertionNonsense_Mutationnovelc.1351_1352insGCTGAGGCTGGGGTACAATGGTGTGATCTGGGCTCACTGTAACCTCCp.Ser451CysfsTer2p.S451Cfs*2Q96ST3protein_codingTCGA-AR-A0TY-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPaclitaxelPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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