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Gene: SIMC1 |
Gene summary for SIMC1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SIMC1 | Gene ID | 375484 |
| Gene name | SUMO interacting motifs containing 1 | |
| Gene Alias | C5orf25 | |
| Cytomap | 5q35.2 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B4DRM7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 375484 | SIMC1 | CCI_2 | Human | Cervix | CC | 3.87e-12 | 1.01e+00 | 0.5249 |
| 375484 | SIMC1 | CCI_3 | Human | Cervix | CC | 9.44e-06 | 5.43e-01 | 0.516 |
| 375484 | SIMC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.45e-15 | -6.36e-01 | 0.0155 |
| 375484 | SIMC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.09e-02 | -5.01e-01 | -0.1808 |
| 375484 | SIMC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-05 | -5.86e-01 | -0.1207 |
| 375484 | SIMC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.73e-09 | -5.08e-01 | -0.1464 |
| 375484 | SIMC1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.01e-04 | -4.41e-01 | -0.1001 |
| 375484 | SIMC1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.59e-02 | -6.76e-01 | -0.1462 |
| 375484 | SIMC1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.23e-02 | -6.34e-01 | -0.0179 |
| 375484 | SIMC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.18e-10 | -5.66e-01 | 0.096 |
| 375484 | SIMC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.31e-07 | -4.88e-01 | 0.0674 |
| 375484 | SIMC1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.87e-05 | -5.48e-01 | 0.0588 |
| 375484 | SIMC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.55e-35 | -7.97e-01 | 0.294 |
| 375484 | SIMC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.41e-10 | -5.07e-01 | 0.3859 |
| 375484 | SIMC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.33e-05 | -6.61e-01 | 0.2585 |
| 375484 | SIMC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.57e-18 | -6.27e-01 | 0.3005 |
| 375484 | SIMC1 | F007 | Human | Colorectum | FAP | 2.35e-03 | -3.05e-01 | 0.1176 |
| 375484 | SIMC1 | A001-C-207 | Human | Colorectum | FAP | 3.07e-03 | -3.11e-01 | 0.1278 |
| 375484 | SIMC1 | A015-C-203 | Human | Colorectum | FAP | 8.11e-34 | -4.91e-01 | -0.1294 |
| 375484 | SIMC1 | A015-C-204 | Human | Colorectum | FAP | 2.06e-08 | -2.78e-01 | -0.0228 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
| GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
| GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
| GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
| GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
| GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
| GO:00525471 | Colorectum | SER | regulation of peptidase activity | 114/2897 | 461/18723 | 1.18e-07 | 7.17e-06 | 114 |
| GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
| GO:0051346 | Colorectum | SER | negative regulation of hydrolase activity | 82/2897 | 379/18723 | 8.19e-04 | 1.01e-02 | 82 |
| GO:0010466 | Colorectum | SER | negative regulation of peptidase activity | 57/2897 | 262/18723 | 4.15e-03 | 3.38e-02 | 57 |
| GO:00525472 | Colorectum | MSS | regulation of peptidase activity | 130/3467 | 461/18723 | 1.81e-07 | 8.13e-06 | 130 |
| GO:00458612 | Colorectum | MSS | negative regulation of proteolysis | 97/3467 | 351/18723 | 1.57e-05 | 3.54e-04 | 97 |
| GO:00513461 | Colorectum | MSS | negative regulation of hydrolase activity | 92/3467 | 379/18723 | 2.85e-03 | 2.22e-02 | 92 |
| GO:00525474 | Colorectum | FAP | regulation of peptidase activity | 86/2622 | 461/18723 | 2.98e-03 | 2.27e-02 | 86 |
| GO:00458614 | Colorectum | FAP | negative regulation of proteolysis | 68/2622 | 351/18723 | 3.07e-03 | 2.31e-02 | 68 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SIMC1 | SNV | Missense_Mutation | c.1076N>T | p.Ser359Leu | p.S359L | protein_coding | tolerated_low_confidence(0.19) | probably_damaging(0.943) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| SIMC1 | SNV | Missense_Mutation | novel | c.1612N>A | p.Glu538Lys | p.E538K | protein_coding | deleterious(0.02) | possibly_damaging(0.448) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
| SIMC1 | SNV | Missense_Mutation | rs756201624 | c.814N>T | p.Arg272Trp | p.R272W | protein_coding | tolerated_low_confidence(0.17) | benign(0.335) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SIMC1 | SNV | Missense_Mutation | rs564067290 | c.2209N>T | p.Arg737Cys | p.R737C | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AR-A0TW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD | |
| SIMC1 | SNV | Missense_Mutation | novel | c.566G>A | p.Ser189Asn | p.S189N | protein_coding | tolerated_low_confidence(0.08) | benign(0.007) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SIMC1 | SNV | Missense_Mutation | rs756044825 | c.1910N>G | p.Val637Gly | p.V637G | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-D8-A1JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine | SD | |
| SIMC1 | SNV | Missense_Mutation | rs756044825 | c.1910N>G | p.Val637Gly | p.V637G | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-E9-A1NG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
| SIMC1 | SNV | Missense_Mutation | rs756044825 | c.1910T>G | p.Val637Gly | p.V637G | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| SIMC1 | SNV | Missense_Mutation | rs756044825 | c.1910T>G | p.Val637Gly | p.V637G | protein_coding | deleterious(0.01) | possibly_damaging(0.893) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| SIMC1 | SNV | Missense_Mutation | novel | c.926N>T | p.Pro309Leu | p.P309L | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.548) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
| Page: 1 2 3 4 5 6 7 8 9 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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