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Gene: SIM2 |
Gene summary for SIM2 |
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Gene information | Species | Human | Gene symbol | SIM2 | Gene ID | 6493 |
Gene name | SIM bHLH transcription factor 2 | |
Gene Alias | HMC13F06 | |
Cytomap | 21q22.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q14190 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6493 | SIM2 | LZE22T | Human | Esophagus | ESCC | 1.07e-02 | 1.60e-01 | 0.068 |
6493 | SIM2 | LZE24T | Human | Esophagus | ESCC | 1.04e-06 | 2.85e-01 | 0.0596 |
6493 | SIM2 | P4T-E | Human | Esophagus | ESCC | 5.57e-17 | 5.57e-01 | 0.1323 |
6493 | SIM2 | P8T-E | Human | Esophagus | ESCC | 1.25e-04 | -5.09e-02 | 0.0889 |
6493 | SIM2 | P9T-E | Human | Esophagus | ESCC | 2.90e-03 | -6.78e-02 | 0.1131 |
6493 | SIM2 | P10T-E | Human | Esophagus | ESCC | 1.58e-07 | 2.27e-02 | 0.116 |
6493 | SIM2 | P12T-E | Human | Esophagus | ESCC | 1.42e-05 | -3.53e-02 | 0.1122 |
6493 | SIM2 | P16T-E | Human | Esophagus | ESCC | 2.07e-08 | -3.77e-02 | 0.1153 |
6493 | SIM2 | P21T-E | Human | Esophagus | ESCC | 1.07e-02 | -3.17e-02 | 0.1617 |
6493 | SIM2 | P22T-E | Human | Esophagus | ESCC | 2.14e-02 | -8.03e-02 | 0.1236 |
6493 | SIM2 | P23T-E | Human | Esophagus | ESCC | 1.93e-07 | 5.51e-01 | 0.108 |
6493 | SIM2 | P26T-E | Human | Esophagus | ESCC | 3.54e-04 | -8.29e-02 | 0.1276 |
6493 | SIM2 | P27T-E | Human | Esophagus | ESCC | 1.25e-11 | 1.50e-01 | 0.1055 |
6493 | SIM2 | P28T-E | Human | Esophagus | ESCC | 6.65e-08 | 3.45e-02 | 0.1149 |
6493 | SIM2 | P31T-E | Human | Esophagus | ESCC | 4.04e-03 | -8.10e-02 | 0.1251 |
6493 | SIM2 | P32T-E | Human | Esophagus | ESCC | 1.66e-02 | -1.48e-01 | 0.1666 |
6493 | SIM2 | P39T-E | Human | Esophagus | ESCC | 2.11e-02 | -1.21e-01 | 0.0894 |
6493 | SIM2 | P48T-E | Human | Esophagus | ESCC | 1.15e-03 | -8.02e-02 | 0.0959 |
6493 | SIM2 | P52T-E | Human | Esophagus | ESCC | 3.96e-04 | -9.87e-02 | 0.1555 |
6493 | SIM2 | P57T-E | Human | Esophagus | ESCC | 4.67e-14 | 1.80e-01 | 0.0926 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIM2 | SNV | Missense_Mutation | rs534777844 | c.758N>T | p.Thr253Met | p.T253M | Q14190 | protein_coding | tolerated(0.26) | probably_damaging(0.997) | TCGA-B6-A40C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | cyclophosphamide | SD |
SIM2 | deletion | Frame_Shift_Del | novel | c.102delN | p.Ser35ArgfsTer16 | p.S35Rfs*16 | Q14190 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SIM2 | SNV | Missense_Mutation | c.1104A>C | p.Lys368Asn | p.K368N | Q14190 | protein_coding | deleterious(0.02) | benign(0.06) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SIM2 | SNV | Missense_Mutation | c.1508N>A | p.Ser503Tyr | p.S503Y | Q14190 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SIM2 | SNV | Missense_Mutation | novel | c.1557N>A | p.Ser519Arg | p.S519R | Q14190 | protein_coding | tolerated_low_confidence(0.1) | benign(0.162) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SIM2 | SNV | Missense_Mutation | c.170N>T | p.Pro57Leu | p.P57L | Q14190 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SIM2 | SNV | Missense_Mutation | c.670N>A | p.Glu224Lys | p.E224K | Q14190 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SIM2 | SNV | Missense_Mutation | c.635C>T | p.Ala212Val | p.A212V | Q14190 | protein_coding | tolerated(0.05) | probably_damaging(0.994) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
SIM2 | deletion | Frame_Shift_Del | novel | c.1485delN | p.Leu497Ter | p.L497* | Q14190 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SIM2 | SNV | Missense_Mutation | novel | c.766N>A | p.Glu256Lys | p.E256K | Q14190 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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