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Gene: SIKE1 |
Gene summary for SIKE1 |
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Gene information | Species | Human | Gene symbol | SIKE1 | Gene ID | 80143 |
Gene name | suppressor of IKBKE 1 | |
Gene Alias | SIKE | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BRV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80143 | SIKE1 | LZE4T | Human | Esophagus | ESCC | 1.30e-09 | 2.15e-01 | 0.0811 |
80143 | SIKE1 | LZE7T | Human | Esophagus | ESCC | 1.86e-03 | 3.13e-01 | 0.0667 |
80143 | SIKE1 | LZE20T | Human | Esophagus | ESCC | 7.99e-04 | 1.06e-01 | 0.0662 |
80143 | SIKE1 | LZE24T | Human | Esophagus | ESCC | 1.83e-07 | 3.13e-01 | 0.0596 |
80143 | SIKE1 | LZE6T | Human | Esophagus | ESCC | 4.34e-03 | 1.49e-01 | 0.0845 |
80143 | SIKE1 | P1T-E | Human | Esophagus | ESCC | 5.51e-03 | 3.77e-01 | 0.0875 |
80143 | SIKE1 | P2T-E | Human | Esophagus | ESCC | 2.36e-28 | 5.87e-01 | 0.1177 |
80143 | SIKE1 | P4T-E | Human | Esophagus | ESCC | 7.30e-33 | 7.52e-01 | 0.1323 |
80143 | SIKE1 | P5T-E | Human | Esophagus | ESCC | 3.52e-32 | 7.01e-01 | 0.1327 |
80143 | SIKE1 | P8T-E | Human | Esophagus | ESCC | 4.40e-16 | 2.40e-01 | 0.0889 |
80143 | SIKE1 | P9T-E | Human | Esophagus | ESCC | 1.87e-13 | 3.82e-01 | 0.1131 |
80143 | SIKE1 | P10T-E | Human | Esophagus | ESCC | 4.97e-38 | 6.38e-01 | 0.116 |
80143 | SIKE1 | P11T-E | Human | Esophagus | ESCC | 4.57e-14 | 5.06e-01 | 0.1426 |
80143 | SIKE1 | P12T-E | Human | Esophagus | ESCC | 3.48e-29 | 4.73e-01 | 0.1122 |
80143 | SIKE1 | P15T-E | Human | Esophagus | ESCC | 1.62e-08 | 2.19e-01 | 0.1149 |
80143 | SIKE1 | P16T-E | Human | Esophagus | ESCC | 5.82e-19 | 3.71e-01 | 0.1153 |
80143 | SIKE1 | P17T-E | Human | Esophagus | ESCC | 3.28e-08 | 5.67e-01 | 0.1278 |
80143 | SIKE1 | P19T-E | Human | Esophagus | ESCC | 1.49e-08 | 7.97e-01 | 0.1662 |
80143 | SIKE1 | P20T-E | Human | Esophagus | ESCC | 2.03e-20 | 3.96e-01 | 0.1124 |
80143 | SIKE1 | P21T-E | Human | Esophagus | ESCC | 1.67e-26 | 7.32e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04622 | Oral cavity | OSCC | RIG-I-like receptor signaling pathway | 41/3704 | 71/8465 | 1.20e-02 | 2.63e-02 | 1.34e-02 | 41 |
hsa046221 | Oral cavity | OSCC | RIG-I-like receptor signaling pathway | 41/3704 | 71/8465 | 1.20e-02 | 2.63e-02 | 1.34e-02 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIKE1 | SNV | Missense_Mutation | novel | c.383C>T | p.Ala128Val | p.A128V | Q9BRV8 | protein_coding | tolerated(0.17) | benign(0.173) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SIKE1 | SNV | Missense_Mutation | c.91N>T | p.Asp31Tyr | p.D31Y | Q9BRV8 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SIKE1 | SNV | Missense_Mutation | c.311N>T | p.Ala104Val | p.A104V | Q9BRV8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIKE1 | SNV | Missense_Mutation | rs762957321 | c.254N>C | p.Arg85Thr | p.R85T | Q9BRV8 | protein_coding | deleterious(0) | possibly_damaging(0.794) | TCGA-A5-A7WK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SIKE1 | SNV | Missense_Mutation | novel | c.346N>G | p.Met116Val | p.M116V | Q9BRV8 | protein_coding | tolerated(0.22) | benign(0.09) | TCGA-AX-A05Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SIKE1 | SNV | Missense_Mutation | novel | c.39G>T | p.Lys13Asn | p.K13N | Q9BRV8 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SIKE1 | SNV | Missense_Mutation | novel | c.142A>C | p.Thr48Pro | p.T48P | Q9BRV8 | protein_coding | deleterious(0.04) | benign(0.191) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIKE1 | SNV | Missense_Mutation | c.374C>T | p.Ala125Val | p.A125V | Q9BRV8 | protein_coding | tolerated(0.12) | benign(0.023) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
SIKE1 | SNV | Missense_Mutation | c.478G>T | p.Val160Phe | p.V160F | Q9BRV8 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SIKE1 | SNV | Missense_Mutation | novel | c.164N>T | p.Arg55Met | p.R55M | Q9BRV8 | protein_coding | deleterious(0.05) | benign(0.299) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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