Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SIK1

Gene summary for SIK1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SIK1

Gene ID

150094

Gene namesalt inducible kinase 1
Gene AliasDEE30
Cytomap21q22.3
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

P57059


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
150094SIK1P5T-EHumanEsophagusESCC3.89e-122.16e-010.1327
150094SIK1P9T-EHumanEsophagusESCC1.23e-143.26e-010.1131
150094SIK1P11T-EHumanEsophagusESCC3.66e-115.38e-010.1426
150094SIK1P12T-EHumanEsophagusESCC3.75e-039.48e-020.1122
150094SIK1P22T-EHumanEsophagusESCC8.84e-051.24e-010.1236
150094SIK1P23T-EHumanEsophagusESCC3.88e-041.49e-010.108
150094SIK1P27T-EHumanEsophagusESCC9.20e-061.28e-010.1055
150094SIK1P30T-EHumanEsophagusESCC1.44e-329.69e-010.137
150094SIK1P36T-EHumanEsophagusESCC2.82e-021.08e-010.1187
150094SIK1P37T-EHumanEsophagusESCC3.92e-244.86e-010.1371
150094SIK1P47T-EHumanEsophagusESCC4.12e-112.86e-010.1067
150094SIK1P49T-EHumanEsophagusESCC5.57e-053.14e-010.1768
150094SIK1P57T-EHumanEsophagusESCC7.90e-039.21e-020.0926
150094SIK1P62T-EHumanEsophagusESCC2.13e-091.99e-010.1302
150094SIK1P65T-EHumanEsophagusESCC6.43e-061.45e-010.0978
150094SIK1P76T-EHumanEsophagusESCC2.06e-081.69e-010.1207
150094SIK1P80T-EHumanEsophagusESCC3.16e-031.31e-010.155
150094SIK1P94T-EHumanEsophagusESCC6.05e-032.95e-010.0879
150094SIK1P126T-EHumanEsophagusESCC7.86e-042.76e-010.1125
150094SIK1P127T-EHumanEsophagusESCC3.68e-102.11e-010.0826
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000734615EsophagusESCCregulation of mitotic cell cycle293/8552457/187238.00e-165.64e-14293
GO:0071496111EsophagusESCCcellular response to external stimulus215/8552320/187234.29e-152.43e-13215
GO:0031668111EsophagusESCCcellular response to extracellular stimulus168/8552246/187234.93e-132.23e-11168
GO:0031669110EsophagusESCCcellular response to nutrient levels148/8552215/187234.58e-121.76e-10148
GO:0031667111EsophagusESCCresponse to nutrient levels289/8552474/187239.25e-123.47e-10289
GO:000931419EsophagusESCCresponse to radiation277/8552456/187234.42e-111.43e-09277
GO:0009267110EsophagusESCCcellular response to starvation110/8552156/187232.63e-107.37e-09110
GO:004259419EsophagusESCCresponse to starvation133/8552197/187234.31e-101.14e-08133
GO:00059969EsophagusESCCmonosaccharide metabolic process159/8552257/187231.11e-071.81e-06159
GO:00193189EsophagusESCChexose metabolic process147/8552237/187232.63e-073.94e-06147
GO:00450175EsophagusESCCglycerolipid biosynthetic process154/8552252/187235.20e-076.96e-06154
GO:00510908EsophagusESCCregulation of DNA-binding transcription factor activity252/8552440/187235.22e-076.97e-06252
GO:004677710EsophagusESCCprotein autophosphorylation138/8552227/187232.98e-063.38e-05138
GO:00060069EsophagusESCCglucose metabolic process119/8552196/187231.51e-051.36e-04119
GO:000941611EsophagusESCCresponse to light stimulus183/8552320/187232.03e-051.76e-04183
GO:00421492EsophagusESCCcellular response to glucose starvation36/855248/187233.43e-052.80e-0436
GO:00442626EsophagusESCCcellular carbohydrate metabolic process160/8552283/187231.43e-049.66e-04160
GO:20002093EsophagusESCCregulation of anoikis20/855224/187231.69e-041.11e-0320
GO:00432761EsophagusESCCanoikis26/855234/187232.53e-041.55e-0326
GO:00160514EsophagusESCCcarbohydrate biosynthetic process117/8552202/187232.96e-041.79e-03117
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
150094SIK1KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASEinhibitor249565818
150094SIK1KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASEinhibitor178102336BOSUTINIB
150094SIK1KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASEinhibitor249565729
150094SIK1KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASEinhibitor340590212
150094SIK1KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASEinhibitor178102305DASATINIB
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