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Gene: SIDT1 |
Gene summary for SIDT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SIDT1 | Gene ID | 54847 |
| Gene name | SID1 transmembrane family member 1 | |
| Gene Alias | SID-1 | |
| Cytomap | 3q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | Q9NXL6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54847 | SIDT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.32e-04 | -4.50e-01 | 0.0155 |
| 54847 | SIDT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.66e-11 | 5.54e-01 | -0.1954 |
| 54847 | SIDT1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.16e-06 | 9.51e-01 | -0.2602 |
| 54847 | SIDT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.50e-05 | -5.30e-01 | 0.096 |
| 54847 | SIDT1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.65e-03 | -5.23e-01 | 0.0338 |
| 54847 | SIDT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.16e-13 | -4.43e-01 | 0.0674 |
| 54847 | SIDT1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.92e-25 | -5.84e-01 | 0.294 |
| 54847 | SIDT1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.70e-09 | -4.13e-01 | 0.3859 |
| 54847 | SIDT1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.85e-04 | -6.61e-01 | 0.2585 |
| 54847 | SIDT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.74e-34 | -6.89e-01 | 0.3005 |
| 54847 | SIDT1 | A015-C-203 | Human | Colorectum | FAP | 1.23e-24 | -4.25e-01 | -0.1294 |
| 54847 | SIDT1 | A015-C-204 | Human | Colorectum | FAP | 2.07e-02 | -3.76e-01 | -0.0228 |
| 54847 | SIDT1 | A002-C-201 | Human | Colorectum | FAP | 2.64e-10 | -4.35e-01 | 0.0324 |
| 54847 | SIDT1 | A002-C-203 | Human | Colorectum | FAP | 1.08e-04 | -1.74e-01 | 0.2786 |
| 54847 | SIDT1 | A001-C-108 | Human | Colorectum | FAP | 5.99e-12 | -2.16e-01 | -0.0272 |
| 54847 | SIDT1 | A002-C-205 | Human | Colorectum | FAP | 1.32e-14 | -4.54e-01 | -0.1236 |
| 54847 | SIDT1 | A015-C-006 | Human | Colorectum | FAP | 2.65e-07 | -3.93e-01 | -0.0994 |
| 54847 | SIDT1 | A015-C-106 | Human | Colorectum | FAP | 8.07e-09 | -2.13e-01 | -0.0511 |
| 54847 | SIDT1 | A002-C-114 | Human | Colorectum | FAP | 5.46e-12 | -4.54e-01 | -0.1561 |
| 54847 | SIDT1 | A015-C-104 | Human | Colorectum | FAP | 1.94e-24 | -4.80e-01 | -0.1899 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
| GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
| GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
| GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
| GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
| GO:00064031 | Colorectum | SER | RNA localization | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
| GO:00159311 | Colorectum | SER | nucleobase-containing compound transport | 54/2897 | 222/18723 | 3.65e-04 | 5.67e-03 | 54 |
| GO:00512361 | Colorectum | SER | establishment of RNA localization | 42/2897 | 166/18723 | 6.70e-04 | 8.96e-03 | 42 |
| GO:00506571 | Colorectum | SER | nucleic acid transport | 41/2897 | 163/18723 | 8.74e-04 | 1.06e-02 | 41 |
| GO:00506581 | Colorectum | SER | RNA transport | 41/2897 | 163/18723 | 8.74e-04 | 1.06e-02 | 41 |
| GO:00064032 | Colorectum | MSS | RNA localization | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
| GO:00159312 | Colorectum | MSS | nucleobase-containing compound transport | 70/3467 | 222/18723 | 1.92e-06 | 6.01e-05 | 70 |
| GO:00512362 | Colorectum | MSS | establishment of RNA localization | 55/3467 | 166/18723 | 4.54e-06 | 1.27e-04 | 55 |
| GO:00506572 | Colorectum | MSS | nucleic acid transport | 54/3467 | 163/18723 | 5.54e-06 | 1.49e-04 | 54 |
| GO:00506582 | Colorectum | MSS | RNA transport | 54/3467 | 163/18723 | 5.54e-06 | 1.49e-04 | 54 |
| GO:00064034 | Colorectum | FAP | RNA localization | 47/2622 | 201/18723 | 2.27e-04 | 3.22e-03 | 47 |
| GO:00512364 | Colorectum | FAP | establishment of RNA localization | 39/2622 | 166/18723 | 6.71e-04 | 7.28e-03 | 39 |
| GO:00506574 | Colorectum | FAP | nucleic acid transport | 38/2622 | 163/18723 | 9.12e-04 | 9.19e-03 | 38 |
| GO:00506584 | Colorectum | FAP | RNA transport | 38/2622 | 163/18723 | 9.12e-04 | 9.19e-03 | 38 |
| GO:00159314 | Colorectum | FAP | nucleobase-containing compound transport | 45/2622 | 222/18723 | 6.22e-03 | 3.90e-02 | 45 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SIDT1 | SNV | Missense_Mutation | novel | c.1454N>T | p.Cys485Phe | p.C485F | Q9NXL6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0CV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| SIDT1 | SNV | Missense_Mutation | c.802N>C | p.Asp268His | p.D268H | Q9NXL6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SIDT1 | SNV | Missense_Mutation | c.2432N>G | p.Phe811Cys | p.F811C | Q9NXL6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
| SIDT1 | SNV | Missense_Mutation | novel | c.1282G>T | p.Asp428Tyr | p.D428Y | Q9NXL6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| SIDT1 | SNV | Missense_Mutation | rs141835433 | c.2150A>G | p.Tyr717Cys | p.Y717C | Q9NXL6 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| SIDT1 | SNV | Missense_Mutation | novel | c.470N>G | p.Ala157Gly | p.A157G | Q9NXL6 | protein_coding | deleterious(0) | benign(0.268) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
| SIDT1 | SNV | Missense_Mutation | novel | c.2376N>G | p.Phe792Leu | p.F792L | Q9NXL6 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
| SIDT1 | SNV | Missense_Mutation | novel | c.1223T>C | p.Met408Thr | p.M408T | Q9NXL6 | protein_coding | deleterious(0) | benign(0.352) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SIDT1 | SNV | Missense_Mutation | c.1546T>G | p.Leu516Val | p.L516V | Q9NXL6 | protein_coding | tolerated(0.06) | benign(0.149) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| SIDT1 | SNV | Missense_Mutation | c.2324N>A | p.Gly775Glu | p.G775E | Q9NXL6 | protein_coding | tolerated(0.8) | benign(0.001) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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