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Gene: SHOC1 |
Gene summary for SHOC1 |
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Gene information | Species | Human | Gene symbol | SHOC1 | Gene ID | 158401 |
Gene name | shortage in chiasmata 1 | |
Gene Alias | C9orf84 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6ZU10 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158401 | SHOC1 | CCI_1 | Human | Cervix | CC | 2.33e-03 | 5.00e-01 | 0.528 |
158401 | SHOC1 | CCI_2 | Human | Cervix | CC | 6.08e-07 | 5.17e-01 | 0.5249 |
158401 | SHOC1 | CCI_3 | Human | Cervix | CC | 1.16e-14 | 5.03e-01 | 0.516 |
158401 | SHOC1 | RNA-P18T-P18T-2 | Human | Lung | IAC | 1.16e-02 | 8.43e-01 | 0.1129 |
158401 | SHOC1 | RNA-P18T-P18T-4 | Human | Lung | IAC | 1.16e-02 | 7.76e-01 | 0.1024 |
158401 | SHOC1 | RNA-P18T-P18T-6 | Human | Lung | IAC | 1.73e-02 | 8.26e-01 | 0.0856 |
158401 | SHOC1 | RNA-P18T-P18T-8 | Human | Lung | IAC | 1.78e-06 | 1.17e+00 | 0.1151 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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