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Gene: SHISA9 |
Gene summary for SHISA9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SHISA9 | Gene ID | 729993 |
| Gene name | shisa family member 9 | |
| Gene Alias | CKAMP44 | |
| Cytomap | 16p13.12 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B4DS77 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 729993 | SHISA9 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.70e-08 | 1.32e+00 | 0.0216 |
| 729993 | SHISA9 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.85e-03 | -2.78e-01 | -0.1464 |
| 729993 | SHISA9 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.18e-06 | 8.28e-01 | -0.059 |
| 729993 | SHISA9 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.02e-03 | 4.75e-01 | 0.0451 |
| 729993 | SHISA9 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.57e-08 | 8.09e-01 | 0.0338 |
| 729993 | SHISA9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.22e-03 | -2.83e-01 | 0.0674 |
| 729993 | SHISA9 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.08e-02 | 1.34e-01 | 0.294 |
| 729993 | SHISA9 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.40e-21 | 1.21e+00 | 0.281 |
| 729993 | SHISA9 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.87e-03 | -2.04e-01 | 0.3005 |
| 729993 | SHISA9 | F007 | Human | Colorectum | FAP | 1.73e-19 | 1.06e+00 | 0.1176 |
| 729993 | SHISA9 | A002-C-010 | Human | Colorectum | FAP | 9.49e-22 | 7.66e-01 | 0.242 |
| 729993 | SHISA9 | A002-C-203 | Human | Colorectum | FAP | 9.36e-06 | -2.95e-01 | 0.2786 |
| 729993 | SHISA9 | A015-C-202 | Human | Colorectum | FAP | 6.90e-04 | 3.82e-01 | -0.0849 |
| 729993 | SHISA9 | A002-C-116 | Human | Colorectum | FAP | 8.28e-04 | -2.92e-01 | -0.0452 |
| 729993 | SHISA9 | A014-C-008 | Human | Colorectum | FAP | 1.27e-08 | 7.64e-01 | -0.191 |
| 729993 | SHISA9 | F034 | Human | Colorectum | FAP | 1.77e-02 | -2.57e-01 | -0.0665 |
| 729993 | SHISA9 | F072B | Human | Colorectum | FAP | 4.46e-07 | -2.95e-01 | 0.257 |
| 729993 | SHISA9 | CRC-3-11773 | Human | Colorectum | CRC | 2.97e-17 | 7.98e-01 | 0.2564 |
| 729993 | SHISA9 | HCC1 | Human | Liver | HCC | 1.38e-03 | 8.30e-01 | 0.5336 |
| 729993 | SHISA9 | HCC2 | Human | Liver | HCC | 6.18e-11 | 1.06e+00 | 0.5341 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00324091 | Colorectum | MSS | regulation of transporter activity | 78/3467 | 310/18723 | 2.09e-03 | 1.78e-02 | 78 |
| GO:0022898 | Colorectum | MSS | regulation of transmembrane transporter activity | 70/3467 | 278/18723 | 3.36e-03 | 2.54e-02 | 70 |
| GO:0032412 | Colorectum | MSS | regulation of ion transmembrane transporter activity | 66/3467 | 267/18723 | 6.72e-03 | 4.38e-02 | 66 |
| GO:00228981 | Colorectum | FAP | regulation of transmembrane transporter activity | 62/2622 | 278/18723 | 1.09e-04 | 1.80e-03 | 62 |
| GO:00324121 | Colorectum | FAP | regulation of ion transmembrane transporter activity | 60/2622 | 267/18723 | 1.12e-04 | 1.84e-03 | 60 |
| GO:00324092 | Colorectum | FAP | regulation of transporter activity | 67/2622 | 310/18723 | 1.59e-04 | 2.43e-03 | 67 |
| GO:1904062 | Colorectum | FAP | regulation of cation transmembrane transport | 69/2622 | 357/18723 | 3.06e-03 | 2.30e-02 | 69 |
| GO:00228982 | Colorectum | CRC | regulation of transmembrane transporter activity | 56/2078 | 278/18723 | 6.75e-06 | 2.58e-04 | 56 |
| GO:00324122 | Colorectum | CRC | regulation of ion transmembrane transporter activity | 54/2078 | 267/18723 | 8.67e-06 | 3.09e-04 | 54 |
| GO:00324093 | Colorectum | CRC | regulation of transporter activity | 59/2078 | 310/18723 | 2.34e-05 | 6.65e-04 | 59 |
| GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
| GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
| GO:19040621 | Colorectum | CRC | regulation of cation transmembrane transport | 58/2078 | 357/18723 | 1.89e-03 | 1.93e-02 | 58 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SHISA9 | SNV | Missense_Mutation | novel | c.818N>C | p.Leu273Pro | p.L273P | B4DS77 | protein_coding | deleterious(0.05) | benign(0.141) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| SHISA9 | SNV | Missense_Mutation | novel | c.346A>C | p.Asn116His | p.N116H | B4DS77 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SHISA9 | SNV | Missense_Mutation | rs750070307 | c.620N>A | p.Arg207Lys | p.R207K | B4DS77 | protein_coding | tolerated(0.93) | probably_damaging(0.946) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
| SHISA9 | SNV | Missense_Mutation | novel | c.1136N>A | p.Arg379Gln | p.R379Q | B4DS77 | protein_coding | tolerated(0.06) | possibly_damaging(0.749) | TCGA-D8-A3Z6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD |
| SHISA9 | SNV | Missense_Mutation | c.1138C>T | p.Arg380Trp | p.R380W | B4DS77 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
| SHISA9 | SNV | Missense_Mutation | c.617N>G | p.Glu206Gly | p.E206G | B4DS77 | protein_coding | tolerated(0.14) | probably_damaging(0.988) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| SHISA9 | SNV | Missense_Mutation | c.997N>G | p.Pro333Ala | p.P333A | B4DS77 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| SHISA9 | SNV | Missense_Mutation | c.172N>A | p.Ala58Thr | p.A58T | B4DS77 | protein_coding | tolerated(0.65) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SHISA9 | SNV | Missense_Mutation | rs752170660 | c.418G>A | p.Asp140Asn | p.D140N | B4DS77 | protein_coding | tolerated(0.26) | benign(0.349) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| SHISA9 | SNV | Missense_Mutation | c.377N>T | p.Pro126Leu | p.P126L | B4DS77 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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