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Gene: SHFL |
Gene summary for SHFL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SHFL | Gene ID | 55337 |
| Gene name | shiftless antiviral inhibitor of ribosomal frameshifting | |
| Gene Alias | C19orf66 | |
| Cytomap | 19p13.2 | |
| Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9NUL5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55337 | SHFL | LZE4T | Human | Esophagus | ESCC | 5.68e-07 | 2.22e-01 | 0.0811 |
| 55337 | SHFL | LZE7T | Human | Esophagus | ESCC | 3.01e-10 | 3.99e-01 | 0.0667 |
| 55337 | SHFL | LZE8T | Human | Esophagus | ESCC | 9.33e-11 | 3.17e-01 | 0.067 |
| 55337 | SHFL | LZE20T | Human | Esophagus | ESCC | 4.88e-05 | 1.97e-01 | 0.0662 |
| 55337 | SHFL | LZE22D1 | Human | Esophagus | HGIN | 8.03e-04 | 2.01e-01 | 0.0595 |
| 55337 | SHFL | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 3.08e-01 | 0.068 |
| 55337 | SHFL | LZE24T | Human | Esophagus | ESCC | 5.87e-40 | 8.64e-01 | 0.0596 |
| 55337 | SHFL | LZE22D3 | Human | Esophagus | HGIN | 1.28e-05 | 5.85e-01 | 0.0653 |
| 55337 | SHFL | LZE21T | Human | Esophagus | ESCC | 1.37e-06 | 3.87e-01 | 0.0655 |
| 55337 | SHFL | LZE6T | Human | Esophagus | ESCC | 7.09e-15 | 4.64e-01 | 0.0845 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
| GO:001603227 | Esophagus | HGIN | viral process | 118/2587 | 415/18723 | 3.01e-15 | 6.22e-13 | 118 |
| GO:001905827 | Esophagus | HGIN | viral life cycle | 93/2587 | 317/18723 | 3.66e-13 | 5.63e-11 | 93 |
| GO:001907926 | Esophagus | HGIN | viral genome replication | 48/2587 | 131/18723 | 4.65e-11 | 5.07e-09 | 48 |
| GO:005079225 | Esophagus | HGIN | regulation of viral process | 50/2587 | 164/18723 | 2.53e-08 | 1.49e-06 | 50 |
| GO:004506919 | Esophagus | HGIN | regulation of viral genome replication | 32/2587 | 85/18723 | 3.61e-08 | 2.04e-06 | 32 |
| GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
| GO:190390025 | Esophagus | HGIN | regulation of viral life cycle | 45/2587 | 148/18723 | 1.36e-07 | 6.78e-06 | 45 |
| GO:000641418 | Esophagus | HGIN | translational elongation | 22/2587 | 55/18723 | 1.46e-06 | 5.56e-05 | 22 |
| GO:00342496 | Esophagus | HGIN | negative regulation of cellular amide metabolic process | 66/2587 | 273/18723 | 2.74e-06 | 9.60e-05 | 66 |
| GO:00171486 | Esophagus | HGIN | negative regulation of translation | 59/2587 | 245/18723 | 1.03e-05 | 2.96e-04 | 59 |
| GO:001908016 | Esophagus | HGIN | viral gene expression | 28/2587 | 94/18723 | 4.52e-05 | 1.09e-03 | 28 |
| GO:00450718 | Esophagus | HGIN | negative regulation of viral genome replication | 19/2587 | 56/18723 | 1.10e-04 | 2.33e-03 | 19 |
| GO:003298415 | Esophagus | HGIN | protein-containing complex disassembly | 50/2587 | 224/18723 | 3.43e-04 | 5.56e-03 | 50 |
| GO:004852510 | Esophagus | HGIN | negative regulation of viral process | 25/2587 | 92/18723 | 5.41e-04 | 7.71e-03 | 25 |
| GO:001908115 | Esophagus | HGIN | viral translation | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
| GO:00343406 | Esophagus | HGIN | response to type I interferon | 17/2587 | 58/18723 | 1.64e-03 | 1.82e-02 | 17 |
| GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
| GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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