![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SHCBP1 |
Gene summary for SHCBP1 |
![]() |
Gene information | Species | Human | Gene symbol | SHCBP1 | Gene ID | 79801 |
Gene name | SHC binding and spindle associated 1 | |
Gene Alias | PAL | |
Cytomap | 16q11.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024R6R1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79801 | SHCBP1 | HCC1_Meng | Human | Liver | HCC | 1.93e-02 | 1.14e-02 | 0.0246 |
79801 | SHCBP1 | HCC1 | Human | Liver | HCC | 3.12e-03 | 1.11e+00 | 0.5336 |
79801 | SHCBP1 | HCC2 | Human | Liver | HCC | 1.60e-10 | 1.46e+00 | 0.5341 |
79801 | SHCBP1 | S028 | Human | Liver | HCC | 6.32e-03 | 1.50e-01 | 0.2503 |
79801 | SHCBP1 | P1_cSCC | Human | Skin | cSCC | 1.91e-02 | 1.22e-01 | 0.0292 |
79801 | SHCBP1 | P2_cSCC | Human | Skin | cSCC | 1.34e-06 | 1.67e-01 | -0.024 |
79801 | SHCBP1 | P4_cSCC | Human | Skin | cSCC | 4.59e-09 | 2.46e-01 | -0.00290000000000005 |
79801 | SHCBP1 | P10_cSCC | Human | Skin | cSCC | 1.80e-06 | 2.41e-01 | 0.1017 |
79801 | SHCBP1 | ATC12 | Human | Thyroid | ATC | 1.09e-02 | 2.16e-01 | 0.34 |
79801 | SHCBP1 | ATC13 | Human | Thyroid | ATC | 1.19e-10 | 2.24e-01 | 0.34 |
79801 | SHCBP1 | ATC2 | Human | Thyroid | ATC | 9.94e-09 | 9.75e-01 | 0.34 |
79801 | SHCBP1 | ATC4 | Human | Thyroid | ATC | 3.08e-07 | 3.15e-01 | 0.34 |
79801 | SHCBP1 | ATC5 | Human | Thyroid | ATC | 1.04e-12 | 2.60e-01 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SHCBP1 | SNV | Missense_Mutation | c.1615N>C | p.Asn539His | p.N539H | Q8NEM2 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
SHCBP1 | SNV | Missense_Mutation | c.1230T>G | p.Asp410Glu | p.D410E | Q8NEM2 | protein_coding | tolerated(0.18) | probably_damaging(0.997) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SHCBP1 | insertion | In_Frame_Ins | novel | c.1747_1748insGCAAATACT | p.Val583delinsGlyLysTyrLeu | p.V583delinsGKYL | Q8NEM2 | protein_coding | TCGA-V7-A7HQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | letrozole | CR | ||
SHCBP1 | SNV | Missense_Mutation | c.797N>A | p.Ser266Asn | p.S266N | Q8NEM2 | protein_coding | tolerated(0.7) | benign(0.006) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SHCBP1 | SNV | Missense_Mutation | c.492N>T | p.Glu164Asp | p.E164D | Q8NEM2 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SHCBP1 | SNV | Missense_Mutation | c.292N>A | p.Val98Ile | p.V98I | Q8NEM2 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SHCBP1 | SNV | Missense_Mutation | rs756162190 | c.1459N>A | p.Ala487Thr | p.A487T | Q8NEM2 | protein_coding | deleterious(0) | possibly_damaging(0.833) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SHCBP1 | SNV | Missense_Mutation | rs767842642 | c.974N>A | p.Arg325His | p.R325H | Q8NEM2 | protein_coding | tolerated(0.05) | possibly_damaging(0.539) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
SHCBP1 | SNV | Missense_Mutation | c.1798G>A | p.Ala600Thr | p.A600T | Q8NEM2 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SHCBP1 | SNV | Missense_Mutation | c.1192G>A | p.Ala398Thr | p.A398T | Q8NEM2 | protein_coding | tolerated(0.49) | benign(0.037) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |