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Gene: SH3BGRL |
Gene summary for SH3BGRL |
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Gene information | Species | Human | Gene symbol | SH3BGRL | Gene ID | 6451 |
Gene name | SH3 domain binding glutamate rich protein like | |
Gene Alias | HEL-S-115 | |
Cytomap | Xq21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O75368 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6451 | SH3BGRL | GSM4909285 | Human | Breast | IDC | 9.25e-03 | -2.11e-01 | 0.21 |
6451 | SH3BGRL | GSM4909286 | Human | Breast | IDC | 2.22e-06 | -8.12e-02 | 0.1081 |
6451 | SH3BGRL | GSM4909289 | Human | Breast | IDC | 1.07e-05 | 6.57e-01 | 0.1064 |
6451 | SH3BGRL | GSM4909290 | Human | Breast | IDC | 1.70e-04 | -3.57e-01 | 0.2096 |
6451 | SH3BGRL | GSM4909293 | Human | Breast | IDC | 2.63e-06 | 2.82e-01 | 0.1581 |
6451 | SH3BGRL | GSM4909294 | Human | Breast | IDC | 3.23e-06 | 3.21e-01 | 0.2022 |
6451 | SH3BGRL | GSM4909296 | Human | Breast | IDC | 3.13e-03 | -3.53e-02 | 0.1524 |
6451 | SH3BGRL | GSM4909297 | Human | Breast | IDC | 4.51e-09 | -1.79e-01 | 0.1517 |
6451 | SH3BGRL | GSM4909298 | Human | Breast | IDC | 3.05e-30 | 7.39e-01 | 0.1551 |
6451 | SH3BGRL | GSM4909303 | Human | Breast | IDC | 5.16e-04 | 5.22e-01 | 0.0438 |
6451 | SH3BGRL | GSM4909304 | Human | Breast | IDC | 1.43e-20 | 5.80e-01 | 0.1636 |
6451 | SH3BGRL | GSM4909306 | Human | Breast | IDC | 1.12e-10 | 4.56e-01 | 0.1564 |
6451 | SH3BGRL | GSM4909308 | Human | Breast | IDC | 1.79e-16 | 5.60e-01 | 0.158 |
6451 | SH3BGRL | GSM4909309 | Human | Breast | IDC | 3.10e-06 | -3.24e-01 | 0.0483 |
6451 | SH3BGRL | GSM4909311 | Human | Breast | IDC | 1.49e-22 | -2.15e-02 | 0.1534 |
6451 | SH3BGRL | GSM4909312 | Human | Breast | IDC | 2.56e-36 | 8.36e-01 | 0.1552 |
6451 | SH3BGRL | GSM4909316 | Human | Breast | IDC | 6.23e-03 | 3.67e-01 | 0.21 |
6451 | SH3BGRL | GSM4909317 | Human | Breast | IDC | 4.71e-02 | -2.84e-01 | 0.1355 |
6451 | SH3BGRL | GSM4909318 | Human | Breast | IDC | 7.88e-03 | -3.66e-01 | 0.2031 |
6451 | SH3BGRL | GSM4909319 | Human | Breast | IDC | 8.72e-28 | -3.06e-01 | 0.1563 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3BGRL | SNV | Missense_Mutation | c.38N>T | p.Ser13Phe | p.S13F | O75368 | protein_coding | tolerated(0.24) | possibly_damaging(0.604) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SH3BGRL | SNV | Missense_Mutation | novel | c.91N>C | p.Lys31Gln | p.K31Q | O75368 | protein_coding | deleterious(0.04) | probably_damaging(0.954) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SH3BGRL | SNV | Missense_Mutation | novel | c.11G>A | p.Arg4His | p.R4H | O75368 | protein_coding | deleterious(0.03) | benign(0.279) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SH3BGRL | SNV | Missense_Mutation | c.227G>A | p.Arg76His | p.R76H | O75368 | protein_coding | deleterious(0.01) | possibly_damaging(0.541) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SH3BGRL | SNV | Missense_Mutation | novel | c.56A>C | p.Lys19Thr | p.K19T | O75368 | protein_coding | deleterious(0) | benign(0.288) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SH3BGRL | SNV | Missense_Mutation | c.132N>T | p.Glu44Asp | p.E44D | O75368 | protein_coding | tolerated(0.37) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SH3BGRL | SNV | Missense_Mutation | rs753066745 | c.226N>T | p.Arg76Cys | p.R76C | O75368 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3BGRL | SNV | Missense_Mutation | c.260N>G | p.Glu87Gly | p.E87G | O75368 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SH3BGRL | SNV | Missense_Mutation | novel | c.185G>A | p.Gly62Asp | p.G62D | O75368 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SH3BGRL | SNV | Missense_Mutation | novel | c.203N>C | p.Gln68Pro | p.Q68P | O75368 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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