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Gene: SGSM1 |
Gene summary for SGSM1 |
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Gene information | Species | Human | Gene symbol | SGSM1 | Gene ID | 129049 |
Gene name | small G protein signaling modulator 1 | |
Gene Alias | RUTBC2 | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q2NKQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
129049 | SGSM1 | HCC1_Meng | Human | Liver | HCC | 1.04e-13 | 1.49e-03 | 0.0246 |
129049 | SGSM1 | HCC1 | Human | Liver | HCC | 2.40e-07 | 1.30e+00 | 0.5336 |
129049 | SGSM1 | HCC2 | Human | Liver | HCC | 8.54e-16 | 2.04e+00 | 0.5341 |
129049 | SGSM1 | HCC5 | Human | Liver | HCC | 2.32e-06 | 1.02e+00 | 0.4932 |
129049 | SGSM1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.75e-04 | 4.40e-01 | 0.2315 |
129049 | SGSM1 | HTA12-23-1 | Human | Pancreas | PDAC | 3.72e-07 | 7.19e-01 | 0.3405 |
129049 | SGSM1 | HTA12-26-1 | Human | Pancreas | PDAC | 2.54e-14 | 7.29e-01 | 0.3728 |
129049 | SGSM1 | HTA12-29-1 | Human | Pancreas | PDAC | 2.01e-36 | 7.93e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SGSM1 | SNV | Missense_Mutation | novel | c.2244N>C | p.Glu748Asp | p.E748D | Q2NKQ1 | protein_coding | tolerated(0.51) | benign(0) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
SGSM1 | SNV | Missense_Mutation | c.2847N>A | p.Asn949Lys | p.N949K | Q2NKQ1 | protein_coding | deleterious(0) | possibly_damaging(0.542) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
SGSM1 | SNV | Missense_Mutation | c.2950N>G | p.Leu984Val | p.L984V | Q2NKQ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
SGSM1 | SNV | Missense_Mutation | novel | c.856G>C | p.Val286Leu | p.V286L | Q2NKQ1 | protein_coding | tolerated(0.7) | benign(0) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
SGSM1 | SNV | Missense_Mutation | rs748312188 | c.1750G>A | p.Asp584Asn | p.D584N | Q2NKQ1 | protein_coding | tolerated(0.1) | benign(0.439) | TCGA-A7-A3J1-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrazole | SD |
SGSM1 | SNV | Missense_Mutation | c.472N>A | p.Glu158Lys | p.E158K | Q2NKQ1 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SGSM1 | SNV | Missense_Mutation | novel | c.1399G>A | p.Glu467Lys | p.E467K | Q2NKQ1 | protein_coding | tolerated(0.73) | benign(0) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
SGSM1 | SNV | Missense_Mutation | novel | c.2188G>T | p.Val730Leu | p.V730L | Q2NKQ1 | protein_coding | deleterious(0.02) | possibly_damaging(0.549) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SGSM1 | SNV | Missense_Mutation | novel | c.2986N>T | p.Ala996Ser | p.A996S | Q2NKQ1 | protein_coding | tolerated(0.4) | benign(0.306) | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
SGSM1 | SNV | Missense_Mutation | rs770730066 | c.634N>T | p.Arg212Trp | p.R212W | Q2NKQ1 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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