Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: SGPL1

Gene summary for SGPL1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SGPL1

Gene ID

8879

Gene namesphingosine-1-phosphate lyase 1
Gene AliasNPHS14
Cytomap10q22.1
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

O95470


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8879SGPL1HTA11_1938_2000001011HumanColorectumAD2.66e-034.70e-01-0.0811
8879SGPL1HTA11_78_2000001011HumanColorectumAD5.20e-033.67e-01-0.1088
8879SGPL1HTA11_347_2000001011HumanColorectumAD8.90e-166.13e-01-0.1954
8879SGPL1A015-C-203HumanColorectumFAP6.22e-16-3.16e-01-0.1294
8879SGPL1A002-C-201HumanColorectumFAP2.17e-04-2.15e-010.0324
8879SGPL1A001-C-108HumanColorectumFAP5.03e-09-2.00e-01-0.0272
8879SGPL1A002-C-205HumanColorectumFAP5.86e-06-2.26e-01-0.1236
8879SGPL1A001-C-104HumanColorectumFAP2.35e-02-1.55e-010.0184
8879SGPL1A015-C-006HumanColorectumFAP1.60e-05-3.16e-01-0.0994
8879SGPL1A015-C-106HumanColorectumFAP5.91e-09-2.26e-01-0.0511
8879SGPL1A002-C-114HumanColorectumFAP7.35e-06-2.88e-01-0.1561
8879SGPL1A015-C-104HumanColorectumFAP1.12e-12-2.48e-01-0.1899
8879SGPL1A001-C-014HumanColorectumFAP2.43e-08-2.35e-010.0135
8879SGPL1A002-C-016HumanColorectumFAP3.18e-08-2.04e-010.0521
8879SGPL1A015-C-002HumanColorectumFAP2.41e-03-2.82e-01-0.0763
8879SGPL1A001-C-203HumanColorectumFAP9.75e-08-1.97e-01-0.0481
8879SGPL1A002-C-116HumanColorectumFAP4.06e-12-2.54e-01-0.0452
8879SGPL1A014-C-008HumanColorectumFAP2.01e-04-2.86e-01-0.191
8879SGPL1A018-E-020HumanColorectumFAP4.09e-05-2.07e-01-0.2034
8879SGPL1F034HumanColorectumFAP4.34e-09-1.77e-01-0.0665
Page: 1 2 3 4 5 6 7 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0048511ColorectumADrhythmic process94/3918298/187231.00e-052.34e-0494
GO:0001667ColorectumADameboidal-type cell migration137/3918475/187232.17e-054.33e-04137
GO:0016042ColorectumADlipid catabolic process97/3918320/187234.31e-057.56e-0497
GO:0006631ColorectumADfatty acid metabolic process114/3918390/187235.58e-059.44e-04114
GO:0044242ColorectumADcellular lipid catabolic process66/3918214/187233.96e-044.50e-0366
GO:0061458ColorectumADreproductive system development116/3918427/187231.11e-031.01e-02116
GO:0009791ColorectumADpost-embryonic development29/391880/187231.13e-031.03e-0229
GO:0048638ColorectumADregulation of developmental growth92/3918330/187231.48e-031.25e-0292
GO:0048608ColorectumADreproductive structure development114/3918424/187231.78e-031.47e-02114
GO:0008202ColorectumADsteroid metabolic process85/3918319/187238.07e-034.75e-0285
GO:00485113ColorectumFAPrhythmic process72/2622298/187231.67e-066.99e-0572
GO:00486382ColorectumFAPregulation of developmental growth75/2622330/187231.11e-053.10e-0475
GO:00016673ColorectumFAPameboidal-type cell migration100/2622475/187231.42e-053.79e-04100
GO:00066313ColorectumFAPfatty acid metabolic process81/2622390/187231.43e-042.24e-0381
GO:00442422ColorectumFAPcellular lipid catabolic process49/2622214/187232.87e-043.77e-0349
GO:00016551ColorectumFAPurogenital system development70/2622338/187234.26e-045.11e-0370
GO:00614583ColorectumFAPreproductive system development85/2622427/187234.30e-045.13e-0385
GO:00097913ColorectumFAPpost-embryonic development23/262280/187234.51e-045.32e-0323
GO:00486083ColorectumFAPreproductive structure development84/2622424/187235.40e-046.10e-0384
GO:0072001ColorectumFAPrenal system development63/2622302/187236.59e-047.19e-0363
Page: 1 2 3 4 5 6 7 8 9 10 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04071ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa040711ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa040714ColorectumFAPSphingolipid signaling pathway34/1404121/84659.53e-045.22e-033.17e-0334
hsa040715ColorectumFAPSphingolipid signaling pathway34/1404121/84659.53e-045.22e-033.17e-0334
hsa040716ColorectumCRCSphingolipid signaling pathway30/1091121/84652.49e-043.09e-032.09e-0330
hsa040717ColorectumCRCSphingolipid signaling pathway30/1091121/84652.49e-043.09e-032.09e-0330
hsa0407116EsophagusESCCSphingolipid signaling pathway85/4205121/84653.04e-061.73e-058.84e-0685
hsa006003EsophagusESCCSphingolipid metabolism36/420553/84655.41e-031.36e-026.99e-0336
hsa0407117EsophagusESCCSphingolipid signaling pathway85/4205121/84653.04e-061.73e-058.84e-0685
hsa0060012EsophagusESCCSphingolipid metabolism36/420553/84655.41e-031.36e-026.99e-0336
hsa040718LiverHCCSphingolipid signaling pathway72/4020121/84655.01e-031.47e-028.18e-0372
hsa00600LiverHCCSphingolipid metabolism34/402053/84651.06e-022.71e-021.51e-0234
hsa0407111LiverHCCSphingolipid signaling pathway72/4020121/84655.01e-031.47e-028.18e-0372
hsa006001LiverHCCSphingolipid metabolism34/402053/84651.06e-022.71e-021.51e-0234
hsa0407114Oral cavityOSCCSphingolipid signaling pathway82/3704121/84656.97e-085.08e-072.58e-0782
hsa006002Oral cavityOSCCSphingolipid metabolism33/370453/84655.00e-031.20e-026.13e-0333
hsa0407115Oral cavityOSCCSphingolipid signaling pathway82/3704121/84656.97e-085.08e-072.58e-0782
hsa0060011Oral cavityOSCCSphingolipid metabolism33/370453/84655.00e-031.20e-026.13e-0333
hsa0407122Oral cavityLPSphingolipid signaling pathway48/2418121/84655.30e-032.15e-021.39e-0248
hsa0407132Oral cavityLPSphingolipid signaling pathway48/2418121/84655.30e-032.15e-021.39e-0248
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SGPL1SNVMissense_Mutationnovelc.95N>Ap.Gly32Glup.G32EO95470protein_codingtolerated(0.9)benign(0.003)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SGPL1SNVMissense_Mutationnovelc.190G>Ap.Glu64Lysp.E64KO95470protein_codingdeleterious(0.03)benign(0.418)TCGA-BH-A2L8-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
SGPL1insertionNonsense_Mutationnovelc.1554_1555insTTAATTAGGGGGTCAGATGTTCTATAAGGAAACCAGTTACATp.Lys518_Thr519insLeuIleArgGlySerAspValLeuTerGlyAsnGlnLeuHisp.K518_T519insLIRGSDVL*GNQLHO95470protein_codingTCGA-A2-A04V-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanPD
SGPL1insertionNonsense_Mutationnovelc.1562_1563insGCGATATAGAGGGCTTAGGGCAGCAGCTTAGGGCTTAGGCCAGACCp.Met522ArgfsTer10p.M522Rfs*10O95470protein_codingTCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
SGPL1SNVMissense_Mutationnovelc.186G>Tp.Gln62Hisp.Q62HO95470protein_codingtolerated(0.07)benign(0.067)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SGPL1SNVMissense_Mutationnovelc.286A>Gp.Lys96Glup.K96EO95470protein_codingtolerated(0.96)benign(0.007)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SGPL1SNVMissense_Mutationnovelc.1679A>Gp.Gln560Argp.Q560RO95470protein_codingtolerated(0.16)benign(0.05)TCGA-C5-A1MN-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
SGPL1SNVMissense_Mutationc.1282N>Tp.Arg428Cysp.R428CO95470protein_codingdeleterious(0)probably_damaging(0.978)TCGA-DS-A0VM-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
SGPL1SNVMissense_Mutationnovelc.494G>Tp.Gly165Valp.G165VO95470protein_codingdeleterious(0.01)benign(0.071)TCGA-IR-A3LA-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SGPL1SNVMissense_Mutationc.306N>Ap.Asn102Lysp.N102KO95470protein_codingtolerated(0.6)benign(0)TCGA-A6-A565-01Colorectumcolon adenocarcinomaFemale<65III/IVUnspecific5FUPD
Page: 1 2 3 4 5 6 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
8879SGPL1ENZYME, DRUGGABLE GENOMEinhibitor252166675
8879SGPL1ENZYME, DRUGGABLE GENOMELX2931LX-2931
8879SGPL1ENZYME, DRUGGABLE GENOMELX3305LX-2931
8879SGPL1ENZYME, DRUGGABLE GENOMEinhibitor363894145LX-2931
Page: 1