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Gene: SFTPA2 |
Gene summary for SFTPA2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SFTPA2 | Gene ID | 729238 |
| Gene name | surfactant protein A2 | |
| Gene Alias | COLEC5 | |
| Cytomap | 10q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0007585 | UniProtAcc | Q8IWL1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 729238 | SFTPA2 | TD9 | Human | Lung | IAC | 2.52e-06 | -1.40e+00 | 0.088 |
| 729238 | SFTPA2 | RNA-P10T1-P10T1-1 | Human | Lung | AIS | 2.71e-02 | -1.02e+00 | -0.0764 |
| 729238 | SFTPA2 | RNA-P10T1-P10T1-2 | Human | Lung | AIS | 2.92e-02 | -1.22e+00 | -0.1028 |
| 729238 | SFTPA2 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 6.39e-03 | -7.21e-01 | -0.1271 |
| 729238 | SFTPA2 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 3.04e-05 | -5.82e-01 | -0.1406 |
| 729238 | SFTPA2 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.01e-04 | -6.47e-01 | -0.1408 |
| 729238 | SFTPA2 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 8.79e-04 | -5.63e-01 | -0.138 |
| 729238 | SFTPA2 | RNA-P17T-P17T-2 | Human | Lung | IAC | 8.27e-11 | -2.47e+00 | 0.3371 |
| 729238 | SFTPA2 | RNA-P17T-P17T-4 | Human | Lung | IAC | 5.50e-10 | -2.47e+00 | 0.343 |
| 729238 | SFTPA2 | RNA-P17T-P17T-6 | Human | Lung | IAC | 5.50e-10 | -2.47e+00 | 0.3385 |
| 729238 | SFTPA2 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.98e-12 | -2.47e+00 | 0.3329 |
| 729238 | SFTPA2 | RNA-P18T-P18T-2 | Human | Lung | IAC | 8.78e-05 | -1.91e+00 | 0.1129 |
| 729238 | SFTPA2 | RNA-P18T-P18T-4 | Human | Lung | IAC | 2.69e-04 | -1.87e+00 | 0.1024 |
| 729238 | SFTPA2 | RNA-P18T-P18T-6 | Human | Lung | IAC | 6.64e-05 | -1.71e+00 | 0.0856 |
| 729238 | SFTPA2 | RNA-P18T-P18T-8 | Human | Lung | IAC | 1.29e-04 | -2.17e+00 | 0.1151 |
| 729238 | SFTPA2 | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 5.69e-06 | -1.26e+00 | -0.037 |
| 729238 | SFTPA2 | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 3.72e-06 | -1.32e+00 | -0.028 |
| 729238 | SFTPA2 | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 5.71e-07 | -2.18e+00 | -0.0272 |
| 729238 | SFTPA2 | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 1.31e-06 | -2.47e+00 | 0.0057 |
| 729238 | SFTPA2 | RNA-P3T-P3T-1 | Human | Lung | IAC | 2.18e-34 | -2.47e+00 | 0.1829 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007585 | Lung | IAC | respiratory gaseous exchange by respiratory system | 18/2061 | 68/18723 | 2.99e-04 | 4.82e-03 | 18 |
| GO:00075851 | Lung | AIS | respiratory gaseous exchange by respiratory system | 15/1849 | 68/18723 | 2.24e-03 | 2.38e-02 | 15 |
| GO:00075852 | Lung | AAH | respiratory gaseous exchange by respiratory system | 8/613 | 68/18723 | 1.65e-03 | 4.01e-02 | 8 |
| GO:00075853 | Lung | MIAC | respiratory gaseous exchange by respiratory system | 11/967 | 68/18723 | 6.76e-04 | 1.59e-02 | 11 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0414516 | Lung | MIAC | Phagosome | 18/507 | 152/8465 | 4.17e-03 | 3.28e-02 | 2.37e-02 | 18 |
| hsa0414517 | Lung | MIAC | Phagosome | 18/507 | 152/8465 | 4.17e-03 | 3.28e-02 | 2.37e-02 | 18 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SFTPA2 | SNV | Missense_Mutation | novel | c.226C>T | p.Pro76Ser | p.P76S | Q8IWL1 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| SFTPA2 | deletion | Frame_Shift_Del | novel | c.727delC | p.Leu243Ter | p.L243* | Q8IWL1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| SFTPA2 | SNV | Missense_Mutation | c.83N>C | p.Gly28Ala | p.G28A | Q8IWL1 | protein_coding | tolerated(0.05) | benign(0.059) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
| SFTPA2 | SNV | Missense_Mutation | c.638G>A | p.Arg213Gln | p.R213Q | Q8IWL1 | protein_coding | tolerated(0.75) | benign(0.006) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| SFTPA2 | SNV | Missense_Mutation | novel | c.313G>A | p.Glu105Lys | p.E105K | Q8IWL1 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| SFTPA2 | SNV | Missense_Mutation | novel | c.100N>A | p.Gly34Ser | p.G34S | Q8IWL1 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SFTPA2 | SNV | Missense_Mutation | novel | c.149N>C | p.Val50Ala | p.V50A | Q8IWL1 | protein_coding | tolerated(0.11) | benign(0.01) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| SFTPA2 | SNV | Missense_Mutation | novel | c.233N>T | p.Ala78Val | p.A78V | Q8IWL1 | protein_coding | tolerated(0.42) | benign(0.087) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| SFTPA2 | SNV | Missense_Mutation | rs759988686 | c.725N>A | p.Arg242Gln | p.R242Q | Q8IWL1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-6172-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
| SFTPA2 | SNV | Missense_Mutation | c.36G>C | p.Leu12Phe | p.L12F | Q8IWL1 | protein_coding | deleterious(0.03) | possibly_damaging(0.562) | TCGA-DC-4749-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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