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Gene: SFTA2 |
Gene summary for SFTA2 |
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Gene information | Species | Human | Gene symbol | SFTA2 | Gene ID | 389376 |
Gene name | surfactant associated 2 | |
Gene Alias | GSGL541 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A1U9X8K0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389376 | SFTA2 | TD9 | Human | Lung | IAC | 8.80e-09 | 1.06e-01 | 0.088 |
389376 | SFTA2 | RNA-P17T-P17T-2 | Human | Lung | IAC | 6.11e-09 | -4.77e-01 | 0.3371 |
389376 | SFTA2 | RNA-P17T-P17T-4 | Human | Lung | IAC | 3.11e-07 | -5.22e-01 | 0.343 |
389376 | SFTA2 | RNA-P17T-P17T-6 | Human | Lung | IAC | 9.35e-07 | -6.36e-01 | 0.3385 |
389376 | SFTA2 | RNA-P17T-P17T-8 | Human | Lung | IAC | 5.83e-10 | -4.55e-01 | 0.3329 |
389376 | SFTA2 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.84e-17 | 4.81e-02 | -0.2116 |
389376 | SFTA2 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 6.35e-06 | -1.77e-01 | -0.1941 |
389376 | SFTA2 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.24e-11 | -3.38e-02 | -0.2107 |
389376 | SFTA2 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.32e-13 | 1.70e-01 | -0.2119 |
389376 | SFTA2 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.52e-07 | -6.23e-01 | 0.1829 |
389376 | SFTA2 | RNA-P3T-P3T-2 | Human | Lung | IAC | 3.51e-09 | -7.15e-01 | 0.1835 |
389376 | SFTA2 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.76e-11 | -4.84e-01 | 0.1859 |
389376 | SFTA2 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.90e-02 | -3.92e-01 | -0.0263 |
389376 | SFTA2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.51e-19 | -1.10e-01 | -0.0166 |
389376 | SFTA2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.40e-24 | -1.86e-01 | -0.0132 |
389376 | SFTA2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 6.00e-36 | -9.79e-02 | -0.013 |
389376 | SFTA2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.15e-24 | -7.00e-02 | -0.0121 |
389376 | SFTA2 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.28e-08 | 6.13e-02 | -0.0961 |
389376 | SFTA2 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.68e-12 | 2.52e-01 | -0.0876 |
389376 | SFTA2 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 8.39e-09 | 7.69e-02 | -0.0822 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SFTA2 | SNV | Missense_Mutation | c.34N>G | p.Thr12Ala | p.T12A | Q6UW10 | protein_coding | tolerated_low_confidence(0.15) | benign(0.018) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SFTA2 | SNV | Missense_Mutation | c.209N>T | p.Ser70Phe | p.S70F | Q6UW10 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SFTA2 | SNV | Missense_Mutation | novel | c.130N>G | p.Phe44Val | p.F44V | Q6UW10 | protein_coding | deleterious(0) | possibly_damaging(0.531) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SFTA2 | SNV | Missense_Mutation | novel | c.200N>G | p.His67Arg | p.H67R | Q6UW10 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-DD-AACQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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