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Gene: SESTD1 |
Gene summary for SESTD1 |
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Gene information | Species | Human | Gene symbol | SESTD1 | Gene ID | 91404 |
Gene name | SEC14 and spectrin domain containing 1 | |
Gene Alias | SOLO | |
Cytomap | 2q31.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B3KTX3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91404 | SESTD1 | AEH-subject1 | Human | Endometrium | AEH | 1.55e-21 | 6.08e-01 | -0.3059 |
91404 | SESTD1 | AEH-subject2 | Human | Endometrium | AEH | 8.92e-07 | 3.23e-01 | -0.2525 |
91404 | SESTD1 | AEH-subject3 | Human | Endometrium | AEH | 1.50e-02 | 2.15e-01 | -0.2576 |
91404 | SESTD1 | AEH-subject4 | Human | Endometrium | AEH | 8.41e-18 | 6.25e-01 | -0.2657 |
91404 | SESTD1 | AEH-subject5 | Human | Endometrium | AEH | 9.11e-27 | 7.89e-01 | -0.2953 |
91404 | SESTD1 | EEC-subject1 | Human | Endometrium | EEC | 8.17e-13 | 5.26e-01 | -0.2682 |
91404 | SESTD1 | EEC-subject2 | Human | Endometrium | EEC | 3.53e-12 | 5.14e-01 | -0.2607 |
91404 | SESTD1 | EEC-subject3 | Human | Endometrium | EEC | 6.40e-13 | 3.94e-01 | -0.2525 |
91404 | SESTD1 | EEC-subject4 | Human | Endometrium | EEC | 9.53e-10 | 3.91e-01 | -0.2571 |
91404 | SESTD1 | EEC-subject5 | Human | Endometrium | EEC | 4.71e-07 | 3.78e-01 | -0.249 |
91404 | SESTD1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 8.01e-04 | -2.84e-02 | -0.1869 |
91404 | SESTD1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.59e-05 | 1.32e-02 | -0.1875 |
91404 | SESTD1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.97e-07 | 1.75e-02 | -0.1883 |
91404 | SESTD1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.29e-05 | 7.84e-02 | -0.1934 |
91404 | SESTD1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.34e-11 | 4.37e-02 | -0.1917 |
91404 | SESTD1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.81e-07 | -3.20e-02 | -0.1916 |
91404 | SESTD1 | LZE24T | Human | Esophagus | ESCC | 1.24e-11 | 3.95e-01 | 0.0596 |
91404 | SESTD1 | P2T-E | Human | Esophagus | ESCC | 3.94e-24 | 3.87e-01 | 0.1177 |
91404 | SESTD1 | P4T-E | Human | Esophagus | ESCC | 1.71e-07 | 6.61e-02 | 0.1323 |
91404 | SESTD1 | P5T-E | Human | Esophagus | ESCC | 3.03e-06 | 5.80e-02 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510515 | Endometrium | AEH | negative regulation of transport | 79/2100 | 470/18723 | 1.51e-04 | 1.99e-03 | 79 |
GO:00109597 | Endometrium | AEH | regulation of metal ion transport | 66/2100 | 406/18723 | 1.24e-03 | 1.07e-02 | 66 |
GO:0034766 | Endometrium | AEH | negative regulation of ion transmembrane transport | 22/2100 | 109/18723 | 4.39e-03 | 2.89e-02 | 22 |
GO:0043271 | Endometrium | AEH | negative regulation of ion transport | 29/2100 | 160/18723 | 6.16e-03 | 3.70e-02 | 29 |
GO:0034763 | Endometrium | AEH | negative regulation of transmembrane transport | 26/2100 | 143/18723 | 8.78e-03 | 4.78e-02 | 26 |
GO:1904063 | Endometrium | AEH | negative regulation of cation transmembrane transport | 20/2100 | 102/18723 | 8.88e-03 | 4.82e-02 | 20 |
GO:19040623 | Endometrium | AEH | regulation of cation transmembrane transport | 55/2100 | 357/18723 | 9.18e-03 | 4.96e-02 | 55 |
GO:005105111 | Endometrium | EEC | negative regulation of transport | 80/2168 | 470/18723 | 2.53e-04 | 2.93e-03 | 80 |
GO:001095914 | Endometrium | EEC | regulation of metal ion transport | 70/2168 | 406/18723 | 4.12e-04 | 4.35e-03 | 70 |
GO:00347661 | Endometrium | EEC | negative regulation of ion transmembrane transport | 22/2168 | 109/18723 | 6.39e-03 | 3.76e-02 | 22 |
GO:19040622 | Lung | IAC | regulation of cation transmembrane transport | 55/2061 | 357/18723 | 6.36e-03 | 4.52e-02 | 55 |
GO:00109595 | Lung | IAC | regulation of metal ion transport | 61/2061 | 406/18723 | 7.31e-03 | 4.98e-02 | 61 |
GO:001095912 | Lung | AIS | regulation of metal ion transport | 58/1849 | 406/18723 | 2.63e-03 | 2.67e-02 | 58 |
GO:0006816 | Lung | AIS | calcium ion transport | 58/1849 | 422/18723 | 6.08e-03 | 4.98e-02 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SESTD1 | SNV | Missense_Mutation | c.794N>A | p.Cys265Tyr | p.C265Y | Q86VW0 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | |
SESTD1 | SNV | Missense_Mutation | c.160N>T | p.Pro54Ser | p.P54S | Q86VW0 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
SESTD1 | SNV | Missense_Mutation | rs756144168 | c.551N>A | p.Ser184Asn | p.S184N | Q86VW0 | protein_coding | tolerated(0.27) | benign(0) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
SESTD1 | insertion | Frame_Shift_Ins | novel | c.1736_1737insCCAAGCCTTACATATCCATTCTGAAAAGG | p.Leu580GlnfsTer14 | p.L580Qfs*14 | Q86VW0 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SESTD1 | SNV | Missense_Mutation | novel | c.1036N>A | p.Glu346Lys | p.E346K | Q86VW0 | protein_coding | tolerated(0.1) | possibly_damaging(0.899) | TCGA-LP-A4AU-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SESTD1 | SNV | Missense_Mutation | rs144405691 | c.802N>T | p.Arg268Cys | p.R268C | Q86VW0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SESTD1 | SNV | Missense_Mutation | c.1954N>G | p.Pro652Ala | p.P652A | Q86VW0 | protein_coding | deleterious(0.04) | probably_damaging(0.971) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
SESTD1 | SNV | Missense_Mutation | novel | c.1562N>G | p.Leu521Arg | p.L521R | Q86VW0 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SESTD1 | SNV | Missense_Mutation | c.1697N>A | p.Cys566Tyr | p.C566Y | Q86VW0 | protein_coding | tolerated(0.21) | probably_damaging(0.974) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SESTD1 | SNV | Missense_Mutation | rs144405691 | c.802N>T | p.Arg268Cys | p.R268C | Q86VW0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AF-2687-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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