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Gene: SERTAD4-AS1 |
Gene summary for SERTAD4-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SERTAD4-AS1 | Gene ID | 574036 |
Gene name | SERTAD4 antisense RNA 1 | |
Gene Alias | C1orf133 | |
Cytomap | 1q32.2 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
574036 | SERTAD4-AS1 | LZE3D | Human | Esophagus | HGIN | 1.15e-02 | 7.98e-01 | 0.0668 |
574036 | SERTAD4-AS1 | LZE20T | Human | Esophagus | ESCC | 3.39e-02 | 1.22e-01 | 0.0662 |
574036 | SERTAD4-AS1 | LZE24T | Human | Esophagus | ESCC | 7.86e-05 | 3.85e-05 | 0.0596 |
574036 | SERTAD4-AS1 | P1T-E | Human | Esophagus | ESCC | 1.19e-06 | 5.42e-01 | 0.0875 |
574036 | SERTAD4-AS1 | P2T-E | Human | Esophagus | ESCC | 4.56e-12 | 9.31e-02 | 0.1177 |
574036 | SERTAD4-AS1 | P4T-E | Human | Esophagus | ESCC | 1.36e-07 | 1.26e-01 | 0.1323 |
574036 | SERTAD4-AS1 | P5T-E | Human | Esophagus | ESCC | 1.95e-07 | 1.48e-01 | 0.1327 |
574036 | SERTAD4-AS1 | P8T-E | Human | Esophagus | ESCC | 3.54e-17 | 4.34e-01 | 0.0889 |
574036 | SERTAD4-AS1 | P9T-E | Human | Esophagus | ESCC | 1.26e-09 | 1.50e-01 | 0.1131 |
574036 | SERTAD4-AS1 | P10T-E | Human | Esophagus | ESCC | 2.22e-14 | 3.23e-01 | 0.116 |
574036 | SERTAD4-AS1 | P11T-E | Human | Esophagus | ESCC | 2.66e-02 | 3.13e-03 | 0.1426 |
574036 | SERTAD4-AS1 | P12T-E | Human | Esophagus | ESCC | 1.49e-09 | 8.88e-02 | 0.1122 |
574036 | SERTAD4-AS1 | P16T-E | Human | Esophagus | ESCC | 2.98e-10 | 3.52e-01 | 0.1153 |
574036 | SERTAD4-AS1 | P17T-E | Human | Esophagus | ESCC | 1.64e-03 | 7.83e-02 | 0.1278 |
574036 | SERTAD4-AS1 | P21T-E | Human | Esophagus | ESCC | 5.54e-08 | 3.22e-01 | 0.1617 |
574036 | SERTAD4-AS1 | P22T-E | Human | Esophagus | ESCC | 3.78e-11 | 3.06e-01 | 0.1236 |
574036 | SERTAD4-AS1 | P23T-E | Human | Esophagus | ESCC | 1.44e-14 | 4.54e-01 | 0.108 |
574036 | SERTAD4-AS1 | P24T-E | Human | Esophagus | ESCC | 1.13e-02 | 2.46e-02 | 0.1287 |
574036 | SERTAD4-AS1 | P26T-E | Human | Esophagus | ESCC | 2.75e-20 | 4.52e-01 | 0.1276 |
574036 | SERTAD4-AS1 | P27T-E | Human | Esophagus | ESCC | 2.21e-05 | -2.49e-02 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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