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Gene: SERPINB11 |
Gene summary for SERPINB11 |
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Gene information | Species | Human | Gene symbol | SERPINB11 | Gene ID | 89778 |
Gene name | serpin family B member 11 | |
Gene Alias | EPIPIN | |
Cytomap | 18q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A096LPD5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89778 | SERPINB11 | LZE24T | Human | Esophagus | ESCC | 5.13e-03 | 2.26e-01 | 0.0596 |
89778 | SERPINB11 | P23T-E | Human | Esophagus | ESCC | 2.33e-11 | 4.31e-01 | 0.108 |
89778 | SERPINB11 | P39T-E | Human | Esophagus | ESCC | 3.52e-19 | 6.64e-01 | 0.0894 |
89778 | SERPINB11 | P54T-E | Human | Esophagus | ESCC | 2.11e-02 | 1.16e-01 | 0.0975 |
89778 | SERPINB11 | P128T-E | Human | Esophagus | ESCC | 8.13e-34 | 1.84e+00 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
GO:0052548111 | Esophagus | ESCC | regulation of endopeptidase activity | 253/8552 | 432/18723 | 3.68e-08 | 6.78e-07 | 253 |
GO:0045861111 | Esophagus | ESCC | negative regulation of proteolysis | 195/8552 | 351/18723 | 1.13e-04 | 7.85e-04 | 195 |
GO:0051346110 | Esophagus | ESCC | negative regulation of hydrolase activity | 208/8552 | 379/18723 | 1.76e-04 | 1.14e-03 | 208 |
GO:001046620 | Esophagus | ESCC | negative regulation of peptidase activity | 140/8552 | 262/18723 | 6.73e-03 | 2.46e-02 | 140 |
GO:001095119 | Esophagus | ESCC | negative regulation of endopeptidase activity | 135/8552 | 252/18723 | 6.86e-03 | 2.51e-02 | 135 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERPINB11 | SNV | Missense_Mutation | rs371694900 | c.839C>T | p.Ala280Val | p.A280V | protein_coding | tolerated(0.08) | benign(0.103) | TCGA-BH-A18I-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
SERPINB11 | SNV | Missense_Mutation | rs747515472 | c.296N>G | p.Ser99Cys | p.S99C | protein_coding | deleterious(0.01) | probably_damaging(0.958) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
SERPINB11 | SNV | Missense_Mutation | c.574N>A | p.Glu192Lys | p.E192K | protein_coding | tolerated(0.45) | possibly_damaging(0.482) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
SERPINB11 | SNV | Missense_Mutation | c.692N>T | p.Ser231Phe | p.S231F | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-C5-A2LS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SERPINB11 | SNV | Missense_Mutation | rs376671929 | c.439N>G | p.Leu147Val | p.L147V | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SERPINB11 | SNV | Missense_Mutation | c.563N>G | p.Ser188Cys | p.S188C | protein_coding | deleterious(0.02) | probably_damaging(0.914) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
SERPINB11 | SNV | Missense_Mutation | rs766193301 | c.454N>A | p.Val152Ile | p.V152I | protein_coding | tolerated(0.34) | benign(0.436) | TCGA-AA-3680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PD | |
SERPINB11 | SNV | Missense_Mutation | novel | c.284N>G | p.Asn95Ser | p.N95S | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SERPINB11 | SNV | Missense_Mutation | c.5N>A | p.Gly2Asp | p.G2D | protein_coding | tolerated(0.72) | benign(0.003) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SERPINB11 | SNV | Missense_Mutation | novel | c.245N>T | p.Arg82Ile | p.R82I | protein_coding | deleterious(0.01) | benign(0.028) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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