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Gene: SERPINA6 |
Gene summary for SERPINA6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SERPINA6 | Gene ID | 866 |
| Gene name | serpin family A member 6 | |
| Gene Alias | CBG | |
| Cytomap | 14q32.13 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P08185 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 866 | SERPINA6 | GSM4909301 | Human | Breast | IDC | 1.48e-02 | 1.59e-01 | 0.1577 |
| 866 | SERPINA6 | GSM4909319 | Human | Breast | IDC | 7.79e-05 | 3.74e-01 | 0.1563 |
| 866 | SERPINA6 | P3 | Human | Breast | IDC | 9.65e-22 | 1.03e+00 | 0.1542 |
| 866 | SERPINA6 | S43 | Human | Liver | Cirrhotic | 7.92e-14 | -2.71e-01 | -0.0187 |
| 866 | SERPINA6 | HCC1_Meng | Human | Liver | HCC | 1.18e-76 | 2.13e-01 | 0.0246 |
| 866 | SERPINA6 | HCC2_Meng | Human | Liver | HCC | 5.45e-12 | -4.66e-01 | 0.0107 |
| 866 | SERPINA6 | cirrhotic1 | Human | Liver | Cirrhotic | 2.48e-15 | 4.16e-01 | 0.0202 |
| 866 | SERPINA6 | cirrhotic2 | Human | Liver | Cirrhotic | 2.67e-27 | 5.53e-01 | 0.0201 |
| 866 | SERPINA6 | HCC1 | Human | Liver | HCC | 1.06e-04 | 4.19e+00 | 0.5336 |
| 866 | SERPINA6 | HCC2 | Human | Liver | HCC | 1.36e-26 | 4.92e+00 | 0.5341 |
| 866 | SERPINA6 | HCC5 | Human | Liver | HCC | 5.52e-07 | 1.13e+00 | 0.4932 |
| 866 | SERPINA6 | Pt13.b | Human | Liver | HCC | 2.62e-06 | 2.99e-03 | 0.0251 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
| GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
| GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
| GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
| GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
| GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
| GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
| GO:005254712 | Liver | Cirrhotic | regulation of peptidase activity | 185/4634 | 461/18723 | 1.32e-13 | 1.09e-11 | 185 |
| GO:005254812 | Liver | Cirrhotic | regulation of endopeptidase activity | 172/4634 | 432/18723 | 2.12e-12 | 1.58e-10 | 172 |
| GO:004586112 | Liver | Cirrhotic | negative regulation of proteolysis | 136/4634 | 351/18723 | 3.46e-09 | 1.42e-07 | 136 |
| GO:005134612 | Liver | Cirrhotic | negative regulation of hydrolase activity | 139/4634 | 379/18723 | 1.24e-07 | 3.42e-06 | 139 |
| GO:001095111 | Liver | Cirrhotic | negative regulation of endopeptidase activity | 98/4634 | 252/18723 | 4.19e-07 | 9.77e-06 | 98 |
| GO:001046612 | Liver | Cirrhotic | negative regulation of peptidase activity | 100/4634 | 262/18723 | 8.90e-07 | 1.84e-05 | 100 |
| GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
| GO:005254722 | Liver | HCC | regulation of peptidase activity | 247/7958 | 461/18723 | 8.28e-07 | 1.27e-05 | 247 |
| GO:005254822 | Liver | HCC | regulation of endopeptidase activity | 230/7958 | 432/18723 | 3.58e-06 | 4.68e-05 | 230 |
| GO:004586122 | Liver | HCC | negative regulation of proteolysis | 186/7958 | 351/18723 | 4.19e-05 | 4.11e-04 | 186 |
| GO:005134622 | Liver | HCC | negative regulation of hydrolase activity | 195/7958 | 379/18723 | 2.44e-04 | 1.82e-03 | 195 |
| GO:001095121 | Liver | HCC | negative regulation of endopeptidase activity | 129/7958 | 252/18723 | 3.17e-03 | 1.47e-02 | 129 |
| GO:001046621 | Liver | HCC | negative regulation of peptidase activity | 132/7958 | 262/18723 | 5.82e-03 | 2.42e-02 | 132 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SERPINA6 | SNV | Missense_Mutation | c.295N>A | p.Glu99Lys | p.E99K | P08185 | protein_coding | tolerated(0.21) | benign(0.078) | TCGA-EA-A44S-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
| SERPINA6 | SNV | Missense_Mutation | rs747671539 | c.586G>A | p.Val196Ile | p.V196I | P08185 | protein_coding | tolerated(1) | benign(0.05) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
| SERPINA6 | SNV | Missense_Mutation | c.1003A>G | p.Thr335Ala | p.T335A | P08185 | protein_coding | tolerated(0.1) | benign(0.118) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| SERPINA6 | SNV | Missense_Mutation | c.1191N>G | p.Phe397Leu | p.F397L | P08185 | protein_coding | tolerated(0.22) | possibly_damaging(0.521) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
| SERPINA6 | SNV | Missense_Mutation | rs781027025 | c.670N>A | p.Asp224Asn | p.D224N | P08185 | protein_coding | tolerated(1) | benign(0.018) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SERPINA6 | SNV | Missense_Mutation | novel | c.342N>C | p.Gln114His | p.Q114H | P08185 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SERPINA6 | SNV | Missense_Mutation | novel | c.640G>T | p.Ala214Ser | p.A214S | P08185 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SERPINA6 | SNV | Missense_Mutation | novel | c.923G>T | p.Gly308Val | p.G308V | P08185 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SERPINA6 | SNV | Missense_Mutation | rs751013186 | c.998G>A | p.Arg333His | p.R333H | P08185 | protein_coding | deleterious(0.03) | benign(0.036) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SERPINA6 | SNV | Missense_Mutation | novel | c.578C>T | p.Ala193Val | p.A193V | P08185 | protein_coding | tolerated(0.09) | benign(0.022) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | RIMEXOLONE | RIMEXOLONE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | Ciclesonide | CICLESONIDE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | PARAMETHASONE | PARAMETHASONE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | CICLESONIDE | CICLESONIDE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | Alclometasone | ALCLOMETASONE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | I-vation | |||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | TRIAMCINOLONE | TRIAMCINOLONE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | Paramethasone | PARAMETHASONE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | BECLOMETHASONE | BECLOMETHASONE | ||
| 866 | SERPINA6 | DRUGGABLE GENOME, PROTEASE INHIBITOR | ALCLOMETASONE | ALCLOMETASONE |
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