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Gene: SERF1A |
Gene summary for SERF1A |
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Gene information | Species | Human | Gene symbol | SERF1A | Gene ID | 8293 |
Gene name | small EDRK-rich factor 1A | |
Gene Alias | 4F5 | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | O75920 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8293 | SERF1A | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.06e-05 | 1.85e-01 | 0.0155 |
8293 | SERF1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.36e-05 | 2.35e-01 | -0.1808 |
8293 | SERF1A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.37e-04 | 3.39e-01 | -0.0811 |
8293 | SERF1A | HTA11_347_2000001011 | Human | Colorectum | AD | 3.19e-20 | 5.07e-01 | -0.1954 |
8293 | SERF1A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.42e-03 | 2.66e-01 | -0.1207 |
8293 | SERF1A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.43e-11 | 3.14e-01 | -0.1464 |
8293 | SERF1A | HTA11_866_2000001011 | Human | Colorectum | AD | 5.66e-10 | 3.18e-01 | -0.1001 |
8293 | SERF1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.71e-09 | 3.32e-01 | -0.059 |
8293 | SERF1A | HTA11_546_2000001011 | Human | Colorectum | AD | 1.05e-05 | 3.10e-01 | -0.0842 |
8293 | SERF1A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.50e-09 | 4.12e-01 | 0.096 |
8293 | SERF1A | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.38e-03 | 3.12e-01 | 0.0131 |
8293 | SERF1A | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.29e-04 | 3.13e-01 | -0.0177 |
8293 | SERF1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.71e-12 | 3.63e-01 | 0.0674 |
8293 | SERF1A | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.21e-03 | 3.04e-01 | 0.0112 |
8293 | SERF1A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.70e-05 | 2.87e-01 | 0.281 |
8293 | SERF1A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.29e-15 | 4.46e-01 | 0.3859 |
8293 | SERF1A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.98e-08 | 4.25e-01 | 0.2585 |
8293 | SERF1A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.23e-06 | 2.33e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:1990000 | Colorectum | AD | amyloid fibril formation | 15/3918 | 34/18723 | 1.96e-03 | 1.58e-02 | 15 |
GO:00316471 | Colorectum | SER | regulation of protein stability | 86/2897 | 298/18723 | 2.56e-09 | 2.42e-07 | 86 |
GO:19900001 | Colorectum | SER | amyloid fibril formation | 13/2897 | 34/18723 | 1.06e-03 | 1.23e-02 | 13 |
GO:00316472 | Colorectum | MSS | regulation of protein stability | 103/3467 | 298/18723 | 2.52e-11 | 3.49e-09 | 103 |
GO:19900002 | Colorectum | MSS | amyloid fibril formation | 15/3467 | 34/18723 | 5.22e-04 | 5.99e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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