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Gene: SEPTIN8 |
Gene summary for SEPTIN8 |
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Gene information | Species | Human | Gene symbol | SEPTIN8 | Gene ID | 23176 |
Gene name | septin 8 | |
Gene Alias | SEP2 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q92599 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23176 | SEPTIN8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.83e-02 | 9.73e-02 | 0.0155 |
23176 | SEPTIN8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.59e-16 | 4.47e-01 | -0.1808 |
23176 | SEPTIN8 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.22e-05 | 3.36e-01 | 0.0216 |
23176 | SEPTIN8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.41e-16 | 4.41e-01 | -0.0811 |
23176 | SEPTIN8 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.65e-10 | 3.19e-01 | -0.1088 |
23176 | SEPTIN8 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.88e-22 | 4.07e-01 | -0.1954 |
23176 | SEPTIN8 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.86e-06 | 4.03e-01 | -0.2602 |
23176 | SEPTIN8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.29e-05 | 3.67e-01 | -0.2196 |
23176 | SEPTIN8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 1.46e-01 | -0.1207 |
23176 | SEPTIN8 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.71e-21 | 6.76e-01 | -0.1526 |
23176 | SEPTIN8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.26e-15 | 2.91e-01 | -0.1464 |
23176 | SEPTIN8 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.47e-08 | 1.85e-01 | -0.1001 |
23176 | SEPTIN8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.30e-10 | 2.74e-01 | -0.059 |
23176 | SEPTIN8 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 3.10e-01 | -0.1706 |
23176 | SEPTIN8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.91e-11 | 4.96e-01 | -0.2061 |
23176 | SEPTIN8 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.52e-01 | -0.1462 |
23176 | SEPTIN8 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.61e-01 | -0.0842 |
23176 | SEPTIN8 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.00410000000000005 |
23176 | SEPTIN8 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.01e-11 | 4.52e-01 | -0.0179 |
23176 | SEPTIN8 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.03e-07 | 2.11e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0061640 | Colorectum | AD | cytoskeleton-dependent cytokinesis | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:00009101 | Colorectum | SER | cytokinesis | 45/2897 | 173/18723 | 2.28e-04 | 3.93e-03 | 45 |
GO:00160501 | Colorectum | SER | vesicle organization | 69/2897 | 300/18723 | 3.59e-04 | 5.61e-03 | 69 |
GO:00616401 | Colorectum | SER | cytoskeleton-dependent cytokinesis | 29/2897 | 100/18723 | 4.25e-04 | 6.25e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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