Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SEPTIN2

Gene summary for SEPTIN2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SEPTIN2

Gene ID

4735

Gene nameseptin 2
Gene AliasDIFF6
Cytomap2q37.3
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q15019


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4735SEPTIN2CA_HPV_1HumanCervixCC2.16e-17-2.70e-010.0264
4735SEPTIN2N_HPV_1HumanCervixN_HPV5.72e-046.36e-020.0079
4735SEPTIN2N_HPV_2HumanCervixN_HPV2.92e-02-1.58e-01-0.0131
4735SEPTIN2CCII_1HumanCervixCC1.16e-09-6.12e-010.3249
4735SEPTIN2TumorHumanCervixCC3.07e-64-8.35e-010.1241
4735SEPTIN2sample1HumanCervixCC3.86e-08-6.34e-010.0959
4735SEPTIN2sample3HumanCervixCC6.56e-058.70e-030.1387
4735SEPTIN2H2HumanCervixHSIL_HPV1.90e-04-2.94e-010.0632
4735SEPTIN2L1HumanCervixCC1.24e-09-5.91e-010.0802
4735SEPTIN2T1HumanCervixCC6.61e-19-6.40e-010.0918
4735SEPTIN2T3HumanCervixCC6.07e-038.24e-030.1389
4735SEPTIN2HTA11_3410_2000001011HumanColorectumAD1.51e-274.97e-010.0155
4735SEPTIN2HTA11_2487_2000001011HumanColorectumSER2.28e-266.35e-01-0.1808
4735SEPTIN2HTA11_2951_2000001011HumanColorectumAD3.03e-064.90e-010.0216
4735SEPTIN2HTA11_1938_2000001011HumanColorectumAD2.14e-461.19e+00-0.0811
4735SEPTIN2HTA11_78_2000001011HumanColorectumAD5.48e-391.07e+00-0.1088
4735SEPTIN2HTA11_347_2000001011HumanColorectumAD8.13e-861.42e+00-0.1954
4735SEPTIN2HTA11_411_2000001011HumanColorectumSER3.33e-151.02e+00-0.2602
4735SEPTIN2HTA11_2112_2000001011HumanColorectumSER1.88e-137.29e-01-0.2196
4735SEPTIN2HTA11_3361_2000001011HumanColorectumAD1.05e-227.27e-01-0.1207
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00009107CervixCCcytokinesis37/2311173/187235.40e-045.23e-0337
GO:00171574CervixCCregulation of exocytosis39/2311202/187232.90e-031.93e-0239
GO:00068873CervixCCexocytosis59/2311352/187238.74e-034.48e-0259
GO:0000910ColorectumADcytokinesis59/3918173/187233.74e-056.75e-0459
GO:0061640ColorectumADcytoskeleton-dependent cytokinesis37/3918100/187231.58e-042.20e-0337
GO:0006887ColorectumADexocytosis96/3918352/187232.48e-031.90e-0296
GO:0017157ColorectumADregulation of exocytosis59/3918202/187233.20e-032.36e-0259
GO:00009101ColorectumSERcytokinesis45/2897173/187232.28e-043.93e-0345
GO:00616401ColorectumSERcytoskeleton-dependent cytokinesis29/2897100/187234.25e-046.25e-0329
GO:00068871ColorectumSERexocytosis75/2897352/187232.05e-032.03e-0275
GO:00171571ColorectumSERregulation of exocytosis45/2897202/187236.46e-034.63e-0245
GO:00009108EndometriumAEHcytokinesis40/2100173/187236.01e-061.49e-0440
GO:00616403EndometriumAEHcytoskeleton-dependent cytokinesis24/2100100/187232.27e-042.75e-0324
GO:000091013EndometriumEECcytokinesis40/2168173/187231.29e-052.60e-0440
GO:006164012EndometriumEECcytoskeleton-dependent cytokinesis24/2168100/187233.66e-043.95e-0324
GO:000091015EsophagusHGINcytokinesis44/2587173/187233.26e-058.32e-0444
GO:00616406EsophagusHGINcytoskeleton-dependent cytokinesis27/2587100/187233.71e-045.77e-0327
GO:000091016EsophagusESCCcytokinesis115/8552173/187232.48e-084.68e-07115
GO:006164015EsophagusESCCcytoskeleton-dependent cytokinesis72/8552100/187238.10e-081.39e-0672
GO:0060271LungIACcilium assembly55/2061337/187231.84e-031.88e-0255
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513120CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa0510020CervixCCBacterial invasion of epithelial cells23/126777/84656.25e-042.93e-031.73e-0323
hsa05131110CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa05100110CervixCCBacterial invasion of epithelial cells23/126777/84656.25e-042.93e-031.73e-0323
hsa0513125CervixHSIL_HPVShigellosis27/459247/84653.78e-043.49e-032.82e-0327
hsa0513135CervixHSIL_HPVShigellosis27/459247/84653.78e-043.49e-032.82e-0327
hsa0513145CervixN_HPVShigellosis23/349247/84652.10e-041.75e-031.37e-0323
hsa0510025CervixN_HPVBacterial invasion of epithelial cells10/34977/84651.17e-037.93e-036.20e-0310
hsa0513155CervixN_HPVShigellosis23/349247/84652.10e-041.75e-031.37e-0323
hsa0510035CervixN_HPVBacterial invasion of epithelial cells10/34977/84651.17e-037.93e-036.20e-0310
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa05100ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa051311ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051001ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa051312ColorectumSERShigellosis87/1580247/84653.07e-107.27e-095.28e-0987
hsa051002ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa051313ColorectumSERShigellosis87/1580247/84653.07e-107.27e-095.28e-0987
hsa051003ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa0513126EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa0510026EndometriumAEHBacterial invasion of epithelial cells32/119777/84653.28e-095.91e-084.33e-0832
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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