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Gene: SEPTIN11 |
Gene summary for SEPTIN11 |
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Gene information | Species | Human | Gene symbol | SEPTIN11 | Gene ID | 55752 |
Gene name | septin 11 | |
Gene Alias | SEPT11 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q9NVA2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55752 | SEPTIN11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.97e-13 | 2.83e-01 | 0.0155 |
55752 | SEPTIN11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.55e-18 | 4.10e-01 | -0.1808 |
55752 | SEPTIN11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.90e-21 | 5.63e-01 | -0.0811 |
55752 | SEPTIN11 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.35e-37 | 8.19e-01 | -0.1088 |
55752 | SEPTIN11 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.20e-72 | 1.22e+00 | -0.1954 |
55752 | SEPTIN11 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.51e-16 | 9.53e-01 | -0.2602 |
55752 | SEPTIN11 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.23e-14 | 6.83e-01 | -0.2196 |
55752 | SEPTIN11 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.10e-17 | 4.74e-01 | -0.1207 |
55752 | SEPTIN11 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.32e-24 | 7.24e-01 | -0.1526 |
55752 | SEPTIN11 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.28e-34 | 6.27e-01 | -0.1464 |
55752 | SEPTIN11 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.40e-44 | 6.95e-01 | -0.1001 |
55752 | SEPTIN11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.37e-31 | 6.44e-01 | -0.059 |
55752 | SEPTIN11 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.79e-16 | 6.23e-01 | -0.1706 |
55752 | SEPTIN11 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.47e-14 | 4.96e-01 | -0.2061 |
55752 | SEPTIN11 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.89e-01 | -0.1462 |
55752 | SEPTIN11 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.81e-22 | 6.94e-01 | -0.0842 |
55752 | SEPTIN11 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.78e-05 | 3.68e-01 | -0.00410000000000005 |
55752 | SEPTIN11 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.38e-12 | 4.97e-01 | -0.0179 |
55752 | SEPTIN11 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.40e-11 | 2.66e-01 | 0.096 |
55752 | SEPTIN11 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.80e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0061640 | Colorectum | AD | cytoskeleton-dependent cytokinesis | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:00009101 | Colorectum | SER | cytokinesis | 45/2897 | 173/18723 | 2.28e-04 | 3.93e-03 | 45 |
GO:00616401 | Colorectum | SER | cytoskeleton-dependent cytokinesis | 29/2897 | 100/18723 | 4.25e-04 | 6.25e-03 | 29 |
GO:00508081 | Colorectum | SER | synapse organization | 85/2897 | 426/18723 | 7.17e-03 | 4.99e-02 | 85 |
GO:00009108 | Endometrium | AEH | cytokinesis | 40/2100 | 173/18723 | 6.01e-06 | 1.49e-04 | 40 |
GO:00616403 | Endometrium | AEH | cytoskeleton-dependent cytokinesis | 24/2100 | 100/18723 | 2.27e-04 | 2.75e-03 | 24 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
GO:000091013 | Endometrium | EEC | cytokinesis | 40/2168 | 173/18723 | 1.29e-05 | 2.60e-04 | 40 |
GO:006164012 | Endometrium | EEC | cytoskeleton-dependent cytokinesis | 24/2168 | 100/18723 | 3.66e-04 | 3.95e-03 | 24 |
GO:005080812 | Endometrium | EEC | synapse organization | 68/2168 | 426/18723 | 3.73e-03 | 2.49e-02 | 68 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:00508085 | Lung | IAC | synapse organization | 65/2061 | 426/18723 | 4.05e-03 | 3.31e-02 | 65 |
GO:00009106 | Lung | IAC | cytokinesis | 31/2061 | 173/18723 | 4.28e-03 | 3.41e-02 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0510026 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05100111 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0510027 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0510036 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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