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Gene: SEPT9 |
Gene summary for SEPT9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SEPT9 | Gene ID | 10801 |
| Gene name | septin 9 | |
| Gene Alias | AF17q25 | |
| Cytomap | 17q25.3 | |
| Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q9UHD8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10801 | SEPT9 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.16e-35 | -7.61e-01 | 0.0155 |
| 10801 | SEPT9 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.46e-21 | -7.61e-01 | -0.1808 |
| 10801 | SEPT9 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.88e-05 | -7.61e-01 | 0.0216 |
| 10801 | SEPT9 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.22e-16 | -7.61e-01 | -0.0811 |
| 10801 | SEPT9 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.70e-25 | -7.61e-01 | -0.1088 |
| 10801 | SEPT9 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.28e-38 | -7.61e-01 | -0.1954 |
| 10801 | SEPT9 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.06e-03 | -7.61e-01 | -0.2602 |
| 10801 | SEPT9 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.69e-04 | -7.61e-01 | -0.2196 |
| 10801 | SEPT9 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.03e-17 | -7.61e-01 | -0.1207 |
| 10801 | SEPT9 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.44e-14 | -7.61e-01 | -0.1526 |
| 10801 | SEPT9 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.12e-43 | -7.61e-01 | -0.1464 |
| 10801 | SEPT9 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.40e-36 | -7.61e-01 | -0.1001 |
| 10801 | SEPT9 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.34e-29 | -7.61e-01 | -0.059 |
| 10801 | SEPT9 | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.01e-07 | -7.61e-01 | -0.1706 |
| 10801 | SEPT9 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.19e-08 | -7.61e-01 | -0.2061 |
| 10801 | SEPT9 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.88e-05 | -7.61e-01 | -0.1462 |
| 10801 | SEPT9 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.37e-12 | -7.61e-01 | -0.0842 |
| 10801 | SEPT9 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.06e-03 | -7.61e-01 | -0.00410000000000005 |
| 10801 | SEPT9 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.39e-10 | -7.61e-01 | -0.0179 |
| 10801 | SEPT9 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.90e-31 | -7.61e-01 | 0.096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
| hsa0510020 | Cervix | CC | Bacterial invasion of epithelial cells | 23/1267 | 77/8465 | 6.25e-04 | 2.93e-03 | 1.73e-03 | 23 |
| hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
| hsa05100110 | Cervix | CC | Bacterial invasion of epithelial cells | 23/1267 | 77/8465 | 6.25e-04 | 2.93e-03 | 1.73e-03 | 23 |
| hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
| hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
| hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
| hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
| hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
| hsa0510026 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
| hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
| hsa05100111 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
| hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
| hsa0510027 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
| hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
| hsa0510036 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SEPT9 | SNV | Missense_Mutation | rs745566208 | c.532N>A | p.Ala178Thr | p.A178T | Q9UHD8 | protein_coding | tolerated_low_confidence(0.46) | benign(0.024) | TCGA-LL-A73Z-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
| SEPT9 | SNV | Missense_Mutation | c.451G>A | p.Glu151Lys | p.E151K | Q9UHD8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.696) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| SEPT9 | SNV | Missense_Mutation | rs760752419 | c.1337C>T | p.Ala446Val | p.A446V | Q9UHD8 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| SEPT9 | SNV | Missense_Mutation | rs866329694 | c.1003N>T | p.Arg335Cys | p.R335C | Q9UHD8 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SEPT9 | SNV | Missense_Mutation | c.287N>T | p.Ser96Leu | p.S96L | Q9UHD8 | protein_coding | deleterious_low_confidence(0.01) | benign(0.079) | TCGA-A6-6650-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SEPT9 | SNV | Missense_Mutation | c.86G>T | p.Arg29Ile | p.R29I | Q9UHD8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| SEPT9 | SNV | Missense_Mutation | c.470N>T | p.Pro157Leu | p.P157L | Q9UHD8 | protein_coding | tolerated_low_confidence(0.13) | possibly_damaging(0.84) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
| SEPT9 | SNV | Missense_Mutation | rs773416606 | c.1711N>A | p.Ala571Thr | p.A571T | Q9UHD8 | protein_coding | tolerated(0.19) | benign(0.196) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SEPT9 | SNV | Missense_Mutation | rs748739459 | c.29N>A | p.Arg10Gln | p.R10Q | Q9UHD8 | protein_coding | tolerated_low_confidence(0.18) | benign(0.02) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| SEPT9 | SNV | Missense_Mutation | c.1090N>T | p.Pro364Ser | p.P364S | Q9UHD8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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