Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SEPT7

Gene summary for SEPT7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SEPT7

Gene ID

989

Gene nameseptin 7
Gene AliasCDC10
Cytomap7p14.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

A8K3D0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
989SEPT7HTA11_3410_2000001011HumanColorectumAD2.86e-28-6.56e-010.0155
989SEPT7HTA11_2487_2000001011HumanColorectumSER6.85e-17-6.56e-01-0.1808
989SEPT7HTA11_2951_2000001011HumanColorectumAD1.39e-03-6.56e-010.0216
989SEPT7HTA11_1938_2000001011HumanColorectumAD7.35e-13-6.56e-01-0.0811
989SEPT7HTA11_78_2000001011HumanColorectumAD7.65e-20-6.56e-01-0.1088
989SEPT7HTA11_347_2000001011HumanColorectumAD2.60e-30-6.56e-01-0.1954
989SEPT7HTA11_2112_2000001011HumanColorectumSER5.87e-03-6.56e-01-0.2196
989SEPT7HTA11_3361_2000001011HumanColorectumAD2.35e-13-6.56e-01-0.1207
989SEPT7HTA11_83_2000001011HumanColorectumSER1.08e-10-6.56e-01-0.1526
989SEPT7HTA11_696_2000001011HumanColorectumAD4.51e-40-6.56e-01-0.1464
989SEPT7HTA11_866_2000001011HumanColorectumAD4.51e-40-6.56e-01-0.1001
989SEPT7HTA11_1391_2000001011HumanColorectumAD5.31e-23-6.56e-01-0.059
989SEPT7HTA11_2992_2000001011HumanColorectumSER8.29e-05-6.56e-01-0.1706
989SEPT7HTA11_5212_2000001011HumanColorectumAD1.06e-05-6.56e-01-0.2061
989SEPT7HTA11_5216_2000001011HumanColorectumSER1.39e-03-6.56e-01-0.1462
989SEPT7HTA11_546_2000001011HumanColorectumAD3.14e-09-6.56e-01-0.0842
989SEPT7HTA11_7862_2000001011HumanColorectumAD1.97e-07-6.56e-01-0.0179
989SEPT7HTA11_866_3004761011HumanColorectumAD5.11e-25-6.56e-010.096
989SEPT7HTA11_4255_2000001011HumanColorectumSER1.39e-03-6.56e-010.0446
989SEPT7HTA11_9408_2000001011HumanColorectumAD2.54e-02-6.56e-010.0451
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513120CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa05131110CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051311ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051312ColorectumSERShigellosis87/1580247/84653.07e-107.27e-095.28e-0987
hsa051313ColorectumSERShigellosis87/1580247/84653.07e-107.27e-095.28e-0987
hsa0513126EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa05131111EndometriumAEHShigellosis78/1197247/84659.23e-132.00e-111.46e-1178
hsa0513127EndometriumEECShigellosis79/1237247/84651.80e-123.95e-112.95e-1179
hsa0513136EndometriumEECShigellosis79/1237247/84651.80e-123.95e-112.95e-1179
hsa0513139EsophagusHGINShigellosis71/1383247/84654.89e-077.98e-066.34e-0671
hsa05131114EsophagusHGINShigellosis71/1383247/84654.89e-077.98e-066.34e-0671
hsa05131211EsophagusESCCShigellosis176/4205247/84652.27e-124.01e-112.05e-11176
hsa05131310EsophagusESCCShigellosis176/4205247/84652.27e-124.01e-112.05e-11176
hsa0513116LungIACShigellosis58/1053247/84658.21e-073.81e-052.53e-0558
hsa0513117LungIACShigellosis58/1053247/84658.21e-073.81e-052.53e-0558
hsa0513123LungAISShigellosis53/961247/84652.70e-069.71e-056.21e-0553
hsa0513133LungAISShigellosis53/961247/84652.70e-069.71e-056.21e-0553
hsa0513143LungMIACShigellosis29/507247/84653.64e-047.06e-035.11e-0329
hsa0513153LungMIACShigellosis29/507247/84653.64e-047.06e-035.11e-0329
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SEPT7SNVMissense_Mutationc.827N>Ap.Arg276Lysp.R276Kprotein_codingtolerated(0.38)benign(0.011)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SEPT7insertionFrame_Shift_Insnovelc.840_841insAATTTACTCCCTGp.Val281AsnfsTer8p.V281Nfs*8protein_codingTCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SEPT7deletionFrame_Shift_Delnovelc.12delNp.Ser4ArgfsTer27p.S4Rfs*27protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
SEPT7SNVMissense_Mutationnovelc.895C>Tp.Pro299Serp.P299Sprotein_codingdeleterious(0.03)possibly_damaging(0.652)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SEPT7SNVMissense_Mutationnovelc.424N>Cp.Glu142Glnp.E142Qprotein_codingdeleterious(0.04)probably_damaging(0.999)TCGA-C5-A8YQ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
SEPT7SNVMissense_Mutationc.1018N>Cp.Glu340Glnp.E340Qprotein_codingtolerated(0.05)probably_damaging(0.935)TCGA-IR-A3LH-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SEPT7SNVMissense_Mutationc.692N>Gp.Tyr231Cysp.Y231Cprotein_codingdeleterious(0)probably_damaging(1)TCGA-CA-6718-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownPD
SEPT7SNVMissense_Mutationrs761757988c.1036N>Tp.Arg346Cysp.R346Cprotein_codingdeleterious(0.02)benign(0.171)TCGA-G4-6586-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
SEPT7SNVMissense_Mutationc.1037G>Ap.Arg346Hisp.R346Hprotein_codingdeleterious(0.03)benign(0.171)TCGA-NH-A5IV-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
SEPT7SNVMissense_Mutationnovelc.632C>Tp.Ala211Valp.A211Vprotein_codingdeleterious(0)probably_damaging(0.974)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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