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Gene: SEPT5 |
Gene summary for SEPT5 |
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Gene information | Species | Human | Gene symbol | SEPT5 | Gene ID | 5413 |
Gene name | septin 5 | |
Gene Alias | CDCREL | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q99719 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5413 | SEPT5 | P2T-E | Human | Esophagus | ESCC | 1.83e-15 | 2.95e-01 | 0.1177 |
5413 | SEPT5 | P4T-E | Human | Esophagus | ESCC | 9.88e-09 | 2.33e-01 | 0.1323 |
5413 | SEPT5 | P5T-E | Human | Esophagus | ESCC | 1.17e-27 | 5.60e-01 | 0.1327 |
5413 | SEPT5 | P9T-E | Human | Esophagus | ESCC | 1.06e-04 | 2.13e-01 | 0.1131 |
5413 | SEPT5 | P10T-E | Human | Esophagus | ESCC | 1.16e-49 | 8.39e-01 | 0.116 |
5413 | SEPT5 | P11T-E | Human | Esophagus | ESCC | 2.46e-08 | 3.74e-01 | 0.1426 |
5413 | SEPT5 | P12T-E | Human | Esophagus | ESCC | 2.16e-18 | 4.27e-01 | 0.1122 |
5413 | SEPT5 | P15T-E | Human | Esophagus | ESCC | 1.84e-07 | 2.29e-01 | 0.1149 |
5413 | SEPT5 | P16T-E | Human | Esophagus | ESCC | 2.16e-47 | 7.57e-01 | 0.1153 |
5413 | SEPT5 | P19T-E | Human | Esophagus | ESCC | 3.27e-09 | 4.61e-01 | 0.1662 |
5413 | SEPT5 | P21T-E | Human | Esophagus | ESCC | 1.04e-39 | 1.10e+00 | 0.1617 |
5413 | SEPT5 | P22T-E | Human | Esophagus | ESCC | 7.22e-17 | 3.52e-01 | 0.1236 |
5413 | SEPT5 | P24T-E | Human | Esophagus | ESCC | 2.86e-04 | 1.47e-01 | 0.1287 |
5413 | SEPT5 | P26T-E | Human | Esophagus | ESCC | 4.79e-31 | 5.82e-01 | 0.1276 |
5413 | SEPT5 | P27T-E | Human | Esophagus | ESCC | 4.02e-15 | 2.61e-01 | 0.1055 |
5413 | SEPT5 | P28T-E | Human | Esophagus | ESCC | 3.41e-21 | 4.12e-01 | 0.1149 |
5413 | SEPT5 | P30T-E | Human | Esophagus | ESCC | 2.07e-25 | 7.99e-01 | 0.137 |
5413 | SEPT5 | P31T-E | Human | Esophagus | ESCC | 2.49e-27 | 4.79e-01 | 0.1251 |
5413 | SEPT5 | P32T-E | Human | Esophagus | ESCC | 1.21e-16 | 3.19e-01 | 0.1666 |
5413 | SEPT5 | P37T-E | Human | Esophagus | ESCC | 1.47e-02 | 1.37e-01 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEPT5 | SNV | Missense_Mutation | novel | c.874N>C | p.Met292Leu | p.M292L | Q99719 | protein_coding | tolerated(0.15) | benign(0.361) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SEPT5 | SNV | Missense_Mutation | c.233N>A | p.Ala78Asp | p.A78D | Q99719 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SEPT5 | SNV | Missense_Mutation | c.613N>T | p.Arg205Trp | p.R205W | Q99719 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A27N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol+adriamycin+cyclophosphamide+herceptin | SD | |
SEPT5 | SNV | Missense_Mutation | c.869N>T | p.Thr290Met | p.T290M | Q99719 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-EA-A3Y4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SEPT5 | SNV | Missense_Mutation | c.1099N>G | p.Gln367Glu | p.Q367E | Q99719 | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-FU-A3TX-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SEPT5 | SNV | Missense_Mutation | c.275N>T | p.Thr92Met | p.T92M | Q99719 | protein_coding | deleterious(0.01) | possibly_damaging(0.835) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SEPT5 | SNV | Missense_Mutation | c.319G>A | p.Val107Met | p.V107M | Q99719 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
SEPT5 | SNV | Missense_Mutation | c.434N>A | p.Arg145Gln | p.R145Q | Q99719 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SEPT5 | SNV | Missense_Mutation | rs750628669 | c.724N>A | p.Ala242Thr | p.A242T | Q99719 | protein_coding | tolerated(0.07) | benign(0.021) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEPT5 | SNV | Missense_Mutation | rs773477864 | c.865C>T | p.Arg289Cys | p.R289C | Q99719 | protein_coding | deleterious(0.03) | benign(0.224) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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