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Gene: SEPT11 |
Gene summary for SEPT11 |
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Gene information | Species | Human | Gene symbol | SEPT11 | Gene ID | 55752 |
Gene name | septin 11 | |
Gene Alias | SEPT11 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q9NVA2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55752 | SEPT11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.92e-37 | -8.00e-01 | 0.0155 |
55752 | SEPT11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-22 | -8.00e-01 | -0.1808 |
55752 | SEPT11 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.22e-05 | -8.00e-01 | 0.0216 |
55752 | SEPT11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.78e-17 | -8.00e-01 | -0.0811 |
55752 | SEPT11 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.50e-26 | -8.00e-01 | -0.1088 |
55752 | SEPT11 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.61e-39 | -8.00e-01 | -0.1954 |
55752 | SEPT11 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.11e-03 | -8.00e-01 | -0.2602 |
55752 | SEPT11 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.71e-05 | -8.00e-01 | -0.2196 |
55752 | SEPT11 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.18e-18 | -8.00e-01 | -0.1207 |
55752 | SEPT11 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.01e-14 | -8.00e-01 | -0.1526 |
55752 | SEPT11 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.08e-52 | -8.00e-01 | -0.1464 |
55752 | SEPT11 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.91e-47 | -8.00e-01 | -0.1001 |
55752 | SEPT11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.56e-30 | -8.00e-01 | -0.059 |
55752 | SEPT11 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.30e-07 | -8.00e-01 | -0.1706 |
55752 | SEPT11 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.38e-08 | -8.00e-01 | -0.2061 |
55752 | SEPT11 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.22e-05 | -8.00e-01 | -0.1462 |
55752 | SEPT11 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.42e-13 | -8.00e-01 | -0.0842 |
55752 | SEPT11 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.11e-03 | -8.00e-01 | -0.00410000000000005 |
55752 | SEPT11 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.46e-10 | -8.00e-01 | -0.0179 |
55752 | SEPT11 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.36e-33 | -8.00e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0510026 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05100111 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0510027 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0510036 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEPT11 | SNV | Missense_Mutation | rs866623127 | c.439C>T | p.Arg147Cys | p.R147C | Q9NVA2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-BH-A0DT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SEPT11 | insertion | In_Frame_Ins | novel | c.909_910insGTCATGACATCTAGTTGGCAGAGT | p.His303_Tyr304insValMetThrSerSerTrpGlnSer | p.H303_Y304insVMTSSWQS | Q9NVA2 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SEPT11 | SNV | Missense_Mutation | novel | c.863N>A | p.Ile288Asn | p.I288N | Q9NVA2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SEPT11 | SNV | Missense_Mutation | c.150N>A | p.Phe50Leu | p.F50L | Q9NVA2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SEPT11 | SNV | Missense_Mutation | novel | c.763N>C | p.Ile255Leu | p.I255L | Q9NVA2 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SEPT11 | SNV | Missense_Mutation | c.305T>C | p.Val102Ala | p.V102A | Q9NVA2 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SEPT11 | SNV | Missense_Mutation | c.71G>A | p.Arg24Gln | p.R24Q | Q9NVA2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SEPT11 | SNV | Missense_Mutation | c.71G>A | p.Arg24Gln | p.R24Q | Q9NVA2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SEPT11 | deletion | Frame_Shift_Del | novel | c.978_979delNN | p.Phe327GlnfsTer7 | p.F327Qfs*7 | Q9NVA2 | protein_coding | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SEPT11 | SNV | Missense_Mutation | c.71N>A | p.Arg24Gln | p.R24Q | Q9NVA2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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