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Gene: SENP3 |
Gene summary for SENP3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SENP3 | Gene ID | 26168 |
Gene name | SUMO specific peptidase 3 | |
Gene Alias | SMT3IP1 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9H4L4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26168 | SENP3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.65e-08 | 2.23e-01 | 0.0155 |
26168 | SENP3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.79e-06 | 2.79e-01 | -0.1808 |
26168 | SENP3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.01e-04 | 4.11e-01 | 0.0216 |
26168 | SENP3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.65e-06 | 2.93e-01 | -0.0811 |
26168 | SENP3 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.56e-09 | 3.00e-01 | -0.1088 |
26168 | SENP3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.13e-20 | 3.91e-01 | -0.1954 |
26168 | SENP3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.69e-05 | 2.73e-01 | -0.1207 |
26168 | SENP3 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.63e-07 | 3.30e-01 | -0.1526 |
26168 | SENP3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.44e-19 | 3.50e-01 | -0.1464 |
26168 | SENP3 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.19e-18 | 3.18e-01 | -0.1001 |
26168 | SENP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.63e-22 | 5.83e-01 | -0.059 |
26168 | SENP3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.67e-04 | 2.97e-01 | -0.2061 |
26168 | SENP3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-08 | 4.11e-01 | -0.0842 |
26168 | SENP3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.53e-03 | 3.63e-01 | -0.00410000000000005 |
26168 | SENP3 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.84e-14 | 4.15e-01 | 0.096 |
26168 | SENP3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.43e-05 | 3.22e-01 | 0.0528 |
26168 | SENP3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.12e-04 | 4.03e-01 | 0.0131 |
26168 | SENP3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.95e-01 | -0.0177 |
26168 | SENP3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.19e-05 | 4.11e-01 | 0.0171 |
26168 | SENP3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.08e-10 | 4.48e-01 | 0.0338 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SENP3 | SNV | Missense_Mutation | novel | c.1197N>C | p.Gln399His | p.Q399H | Q9H4L4 | protein_coding | tolerated(0.24) | probably_damaging(0.969) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
SENP3 | insertion | Nonsense_Mutation | novel | c.479_480insTGATGCTTAGATTTTGATA | p.Leu161AspfsTer3 | p.L161Dfs*3 | Q9H4L4 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
SENP3 | SNV | Missense_Mutation | novel | c.185N>A | p.Arg62His | p.R62H | Q9H4L4 | protein_coding | deleterious_low_confidence(0.05) | benign(0.028) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SENP3 | SNV | Missense_Mutation | novel | c.915N>T | p.Gln305His | p.Q305H | Q9H4L4 | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SENP3 | SNV | Missense_Mutation | novel | c.401N>A | p.Arg134Gln | p.R134Q | Q9H4L4 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SENP3 | SNV | Missense_Mutation | novel | c.1678N>A | p.Arg560Ser | p.R560S | Q9H4L4 | protein_coding | deleterious(0) | possibly_damaging(0.853) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SENP3 | SNV | Missense_Mutation | c.1153N>T | p.Arg385Trp | p.R385W | Q9H4L4 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SENP3 | SNV | Missense_Mutation | c.697N>T | p.Pro233Ser | p.P233S | Q9H4L4 | protein_coding | tolerated(0.21) | probably_damaging(0.968) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SENP3 | SNV | Missense_Mutation | novel | c.85N>T | p.Arg29Trp | p.R29W | Q9H4L4 | protein_coding | deleterious_low_confidence(0) | benign(0.056) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SENP3 | SNV | Missense_Mutation | novel | c.796N>A | p.Ala266Thr | p.A266T | Q9H4L4 | protein_coding | deleterious(0) | possibly_damaging(0.528) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26168 | SENP3 | PROTEASE | methylphenidate | METHYLPHENIDATE | 29382897 |
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