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Gene: SEC14L5 |
Gene summary for SEC14L5 |
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Gene information | Species | Human | Gene symbol | SEC14L5 | Gene ID | 9717 |
Gene name | SEC14 like lipid binding 5 | |
Gene Alias | PRELID4B | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | O43304 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9717 | SEC14L5 | HCC2 | Human | Liver | HCC | 2.08e-08 | 6.18e-01 | 0.5341 |
9717 | SEC14L5 | HCC5 | Human | Liver | HCC | 3.27e-06 | 5.17e-01 | 0.4932 |
9717 | SEC14L5 | S016 | Human | Liver | HCC | 8.53e-05 | 1.57e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEC14L5 | SNV | Missense_Mutation | rs771856728 | c.43C>T | p.Pro15Ser | p.P15S | O43304 | protein_coding | deleterious(0.02) | benign(0.244) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEC14L5 | SNV | Missense_Mutation | novel | c.1889N>C | p.Gly630Ala | p.G630A | O43304 | protein_coding | tolerated(0.79) | benign(0.027) | TCGA-E2-A1LE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | herceptin | PD |
SEC14L5 | deletion | Frame_Shift_Del | c.1730delG | p.Gly577AlafsTer28 | p.G577Afs*28 | O43304 | protein_coding | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |||
SEC14L5 | SNV | Missense_Mutation | rs866773213 | c.1054C>T | p.Arg352Trp | p.R352W | O43304 | protein_coding | deleterious(0.02) | benign(0.112) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SEC14L5 | SNV | Missense_Mutation | c.1768C>G | p.Pro590Ala | p.P590A | O43304 | protein_coding | tolerated(0.13) | benign(0.014) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
SEC14L5 | SNV | Missense_Mutation | c.1216N>A | p.Glu406Lys | p.E406K | O43304 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
SEC14L5 | SNV | Missense_Mutation | rs754852146 | c.560G>A | p.Arg187His | p.R187H | O43304 | protein_coding | tolerated(0.12) | benign(0.031) | TCGA-ZJ-AAXN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SEC14L5 | SNV | Missense_Mutation | rs754852146 | c.560G>A | p.Arg187His | p.R187H | O43304 | protein_coding | tolerated(0.12) | benign(0.031) | TCGA-AA-3858-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SEC14L5 | SNV | Missense_Mutation | rs763855016 | c.1868N>A | p.Ser623Asn | p.S623N | O43304 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SEC14L5 | SNV | Missense_Mutation | c.1775N>C | p.Val592Ala | p.V592A | O43304 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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