Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SEC11A

Gene summary for SEC11A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SEC11A

Gene ID

23478

Gene nameSEC11 homolog A, signal peptidase complex subunit
Gene Alias1810012E07Rik
Cytomap15q25.2-q25.3
Gene Typeprotein-coding
GO ID

GO:0006465

UniProtAcc

P67812


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23478SEC11ACA_HPV_1HumanCervixCC1.12e-04-2.67e-010.0264
23478SEC11ACA_HPV_3HumanCervixCC7.24e-07-6.50e-020.0414
23478SEC11AN_HPV_2HumanCervixN_HPV1.06e-021.11e-02-0.0131
23478SEC11ACCI_3HumanCervixCC1.34e-02-5.22e-010.516
23478SEC11ACCII_1HumanCervixCC4.08e-17-7.82e-010.3249
23478SEC11Asample3HumanCervixCC3.36e-073.30e-030.1387
23478SEC11AL1HumanCervixCC1.60e-05-4.49e-010.0802
23478SEC11AT1HumanCervixCC1.29e-04-3.89e-010.0918
23478SEC11AT3HumanCervixCC3.23e-06-6.99e-040.1389
23478SEC11AHTA11_347_2000001011HumanColorectumAD2.01e-135.87e-01-0.1954
23478SEC11AHTA11_99999970781_79442HumanColorectumMSS8.43e-136.14e-010.294
23478SEC11AA001-C-207HumanColorectumFAP3.81e-02-2.39e-010.1278
23478SEC11AA015-C-203HumanColorectumFAP1.63e-11-2.05e-01-0.1294
23478SEC11AA015-C-204HumanColorectumFAP4.20e-03-2.50e-01-0.0228
23478SEC11AA002-C-201HumanColorectumFAP5.80e-06-2.28e-010.0324
23478SEC11AA002-C-203HumanColorectumFAP4.21e-03-1.90e-010.2786
23478SEC11AA001-C-108HumanColorectumFAP6.58e-09-2.11e-01-0.0272
23478SEC11AA002-C-205HumanColorectumFAP1.26e-07-1.55e-01-0.1236
23478SEC11AA015-C-006HumanColorectumFAP1.58e-07-2.72e-01-0.0994
23478SEC11AA015-C-106HumanColorectumFAP4.55e-05-1.69e-01-0.0511
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00064657CervixCCsignal peptide processing8/231114/187238.01e-051.09e-038
GO:00516048CervixCCprotein maturation56/2311294/187235.90e-045.59e-0356
GO:005160414CervixN_HPVprotein maturation20/534294/187233.17e-044.75e-0320
GO:00164854CervixN_HPVprotein processing15/534225/187232.09e-032.00e-0215
GO:000646511CervixN_HPVsignal peptide processing3/53414/187236.64e-034.45e-023
GO:0006465ColorectumADsignal peptide processing10/391814/187236.90e-051.11e-0310
GO:0051604ColorectumADprotein maturation85/3918294/187236.73e-046.91e-0385
GO:0016485ColorectumADprotein processing63/3918225/187236.77e-034.19e-0263
GO:00064652ColorectumMSSsignal peptide processing11/346714/187231.81e-065.70e-0511
GO:00516042ColorectumMSSprotein maturation75/3467294/187231.70e-031.53e-0275
GO:00164852ColorectumMSSprotein processing57/3467225/187236.60e-034.38e-0257
GO:00064654ColorectumFAPsignal peptide processing6/262214/187238.21e-034.82e-026
GO:00516044ColorectumCRCprotein maturation47/2078294/187236.52e-034.70e-0247
GO:00064658EndometriumAEHsignal peptide processing6/210014/187232.67e-031.94e-026
GO:000646512EndometriumEECsignal peptide processing6/216814/187233.15e-032.16e-026
GO:005160417EsophagusHGINprotein maturation68/2587294/187239.77e-062.86e-0468
GO:000646515EsophagusHGINsignal peptide processing8/258714/187231.81e-043.45e-038
GO:00164857EsophagusHGINprotein processing49/2587225/187237.04e-049.52e-0349
GO:005160418EsophagusESCCprotein maturation189/8552294/187237.64e-112.39e-09189
GO:001648514EsophagusESCCprotein processing134/8552225/187231.81e-051.60e-04134
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0306022CervixN_HPVProtein export5/34923/84652.11e-031.27e-029.96e-035
hsa0306032CervixN_HPVProtein export5/34923/84652.11e-031.27e-029.96e-035
hsa03060ColorectumADProtein export14/209223/84652.43e-041.90e-031.21e-0314
hsa030601ColorectumADProtein export14/209223/84652.43e-041.90e-031.21e-0314
hsa030602ColorectumMSSProtein export15/187523/84651.13e-051.26e-047.71e-0515
hsa030603ColorectumMSSProtein export15/187523/84651.13e-051.26e-047.71e-0515
hsa0306014EndometriumAEHProtein export11/119723/84651.14e-041.06e-037.73e-0411
hsa0306015EndometriumAEHProtein export11/119723/84651.14e-041.06e-037.73e-0411
hsa0306023EndometriumEECProtein export11/123723/84651.54e-041.41e-031.05e-0311
hsa0306033EndometriumEECProtein export11/123723/84651.54e-041.41e-031.05e-0311
hsa0306020EsophagusHGINProtein export13/138323/84651.27e-051.80e-041.43e-0413
hsa03060110EsophagusHGINProtein export13/138323/84651.27e-051.80e-041.43e-0413
hsa0306026EsophagusESCCProtein export22/420523/84652.43e-061.43e-057.32e-0622
hsa0306036EsophagusESCCProtein export22/420523/84652.43e-061.43e-057.32e-0622
hsa030608LiverCirrhoticProtein export20/253023/84652.00e-083.51e-072.17e-0720
hsa0306011LiverCirrhoticProtein export20/253023/84652.00e-083.51e-072.17e-0720
hsa0306021LiverHCCProtein export21/402023/84651.20e-058.53e-054.74e-0521
hsa0306031LiverHCCProtein export21/402023/84651.20e-058.53e-054.74e-0521
hsa0306018Oral cavityOSCCProtein export21/370423/84652.42e-061.27e-056.45e-0621
hsa0306019Oral cavityOSCCProtein export21/370423/84652.42e-061.27e-056.45e-0621
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SEC11ASNVMissense_Mutationnovelc.361G>Cp.Asp121Hisp.D121HP67812protein_codingdeleterious(0.04)probably_damaging(0.92)TCGA-HM-A4S6-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
SEC11ASNVMissense_Mutationnovelc.89N>Tp.Ser30Leup.S30LP67812protein_codingdeleterious(0.04)benign(0.221)TCGA-VS-A9UJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
SEC11ASNVMissense_Mutationnovelc.92N>Tp.Ser31Leup.S31LP67812protein_codingdeleterious(0)possibly_damaging(0.671)TCGA-AJ-A3EL-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
SEC11ASNVMissense_Mutationnovelc.223N>Ap.Asp75Asnp.D75NP67812protein_codingtolerated(0.06)benign(0.209)TCGA-AX-A06F-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinSD
SEC11ASNVMissense_Mutationnovelc.265N>Ap.Gly89Argp.G89RP67812protein_codingdeleterious(0)probably_damaging(0.972)TCGA-AX-A2HD-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
SEC11ASNVMissense_Mutationnovelc.152N>Cp.Val51Alap.V51AP67812protein_codingdeleterious(0.01)possibly_damaging(0.841)TCGA-B5-A11E-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
SEC11ASNVMissense_Mutationnovelc.199N>Tp.Leu67Phep.L67FP67812protein_codingdeleterious(0)probably_damaging(0.928)TCGA-B5-A11N-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
SEC11ASNVMissense_Mutationnovelc.94N>Ap.Ala32Thrp.A32TP67812protein_codingdeleterious(0.03)possibly_damaging(0.779)TCGA-B5-A1MR-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
SEC11ASNVMissense_Mutationnovelc.290N>Tp.Arg97Leup.R97LP67812protein_codingdeleterious(0)probably_damaging(0.997)TCGA-BG-A0VW-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
SEC11ASNVMissense_Mutationnovelc.402N>Tp.Glu134Aspp.E134DP67812protein_codingtolerated(0.2)benign(0.029)TCGA-EO-A3AV-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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