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Gene: SDHAF1 |
Gene summary for SDHAF1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SDHAF1 | Gene ID | 644096 |
| Gene name | succinate dehydrogenase complex assembly factor 1 | |
| Gene Alias | LYRM8 | |
| Cytomap | 19q13.12 | |
| Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A6NFY7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 644096 | SDHAF1 | LZE4T | Human | Esophagus | ESCC | 1.82e-07 | 1.20e-01 | 0.0811 |
| 644096 | SDHAF1 | LZE22D1 | Human | Esophagus | HGIN | 4.60e-02 | 1.10e-01 | 0.0595 |
| 644096 | SDHAF1 | LZE24T | Human | Esophagus | ESCC | 1.30e-11 | 3.08e-01 | 0.0596 |
| 644096 | SDHAF1 | P1T-E | Human | Esophagus | ESCC | 1.49e-06 | 2.25e-01 | 0.0875 |
| 644096 | SDHAF1 | P2T-E | Human | Esophagus | ESCC | 1.66e-10 | 1.76e-01 | 0.1177 |
| 644096 | SDHAF1 | P4T-E | Human | Esophagus | ESCC | 5.54e-21 | 4.60e-01 | 0.1323 |
| 644096 | SDHAF1 | P5T-E | Human | Esophagus | ESCC | 9.78e-20 | 3.15e-01 | 0.1327 |
| 644096 | SDHAF1 | P8T-E | Human | Esophagus | ESCC | 1.15e-29 | 4.10e-01 | 0.0889 |
| 644096 | SDHAF1 | P9T-E | Human | Esophagus | ESCC | 5.21e-22 | 4.16e-01 | 0.1131 |
| 644096 | SDHAF1 | P10T-E | Human | Esophagus | ESCC | 1.88e-40 | 6.38e-01 | 0.116 |
| 644096 | SDHAF1 | P11T-E | Human | Esophagus | ESCC | 1.04e-07 | 3.75e-01 | 0.1426 |
| 644096 | SDHAF1 | P12T-E | Human | Esophagus | ESCC | 3.92e-21 | 3.07e-01 | 0.1122 |
| 644096 | SDHAF1 | P15T-E | Human | Esophagus | ESCC | 1.23e-14 | 3.33e-01 | 0.1149 |
| 644096 | SDHAF1 | P16T-E | Human | Esophagus | ESCC | 9.55e-19 | 1.92e-01 | 0.1153 |
| 644096 | SDHAF1 | P17T-E | Human | Esophagus | ESCC | 6.22e-04 | 2.91e-01 | 0.1278 |
| 644096 | SDHAF1 | P19T-E | Human | Esophagus | ESCC | 3.90e-03 | 6.45e-01 | 0.1662 |
| 644096 | SDHAF1 | P20T-E | Human | Esophagus | ESCC | 7.35e-24 | 5.14e-01 | 0.1124 |
| 644096 | SDHAF1 | P21T-E | Human | Esophagus | ESCC | 1.19e-17 | 2.08e-01 | 0.1617 |
| 644096 | SDHAF1 | P22T-E | Human | Esophagus | ESCC | 1.29e-27 | 4.35e-01 | 0.1236 |
| 644096 | SDHAF1 | P23T-E | Human | Esophagus | ESCC | 2.04e-29 | 7.01e-01 | 0.108 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
| GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
| GO:00331087 | Liver | Cirrhotic | mitochondrial respiratory chain complex assembly | 64/4634 | 93/18723 | 3.85e-19 | 7.79e-17 | 64 |
| GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
| GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
| GO:003310819 | Oral cavity | LP | mitochondrial respiratory chain complex assembly | 63/4623 | 93/18723 | 2.24e-18 | 4.13e-16 | 63 |
| GO:0033108111 | Thyroid | PTC | mitochondrial respiratory chain complex assembly | 65/5968 | 93/18723 | 5.60e-14 | 3.21e-12 | 65 |
| GO:003310832 | Thyroid | ATC | mitochondrial respiratory chain complex assembly | 65/6293 | 93/18723 | 8.86e-13 | 3.81e-11 | 65 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SDHAF1 | SNV | Missense_Mutation | c.272A>G | p.Gln91Arg | p.Q91R | A6NFY7 | protein_coding | tolerated_low_confidence(0.67) | benign(0) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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