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Gene: SCUBE3 |
Gene summary for SCUBE3 |
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Gene information | Species | Human | Gene symbol | SCUBE3 | Gene ID | 222663 |
Gene name | signal peptide, CUB domain and EGF like domain containing 3 | |
Gene Alias | CEGF3 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8IX30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222663 | SCUBE3 | male-WTA | Human | Thyroid | PTC | 3.10e-11 | 7.63e-02 | 0.1037 |
222663 | SCUBE3 | PTC06 | Human | Thyroid | PTC | 1.37e-17 | 3.90e-01 | 0.2057 |
222663 | SCUBE3 | PTC07 | Human | Thyroid | PTC | 8.31e-05 | 1.31e-01 | 0.2044 |
222663 | SCUBE3 | ATC13 | Human | Thyroid | ATC | 3.24e-04 | 1.70e-02 | 0.34 |
222663 | SCUBE3 | ATC5 | Human | Thyroid | ATC | 1.02e-03 | 3.64e-02 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCUBE3 | SNV | Missense_Mutation | novel | c.867C>A | p.Asp289Glu | p.D289E | Q8IX30 | protein_coding | deleterious(0.04) | probably_damaging(0.984) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCUBE3 | SNV | Missense_Mutation | novel | c.2694C>A | p.Phe898Leu | p.F898L | Q8IX30 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCUBE3 | SNV | Missense_Mutation | c.1239N>A | p.Met413Ile | p.M413I | Q8IX30 | protein_coding | tolerated(0.47) | benign(0.007) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCUBE3 | SNV | Missense_Mutation | c.2807C>T | p.Ser936Phe | p.S936F | Q8IX30 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | SD | ||
SCUBE3 | SNV | Missense_Mutation | rs757219770 | c.2704N>A | p.Glu902Lys | p.E902K | Q8IX30 | protein_coding | deleterious(0.01) | possibly_damaging(0.838) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SCUBE3 | SNV | Missense_Mutation | rs200059981 | c.1033C>T | p.Arg345Cys | p.R345C | Q8IX30 | protein_coding | deleterious(0) | benign(0.296) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SCUBE3 | SNV | Missense_Mutation | c.1461C>G | p.Ile487Met | p.I487M | Q8IX30 | protein_coding | deleterious(0) | possibly_damaging(0.691) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SCUBE3 | SNV | Missense_Mutation | novel | c.2725N>A | p.Phe909Ile | p.F909I | Q8IX30 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SCUBE3 | insertion | Frame_Shift_Ins | novel | c.869_870insT | p.Ile291TyrfsTer18 | p.I291Yfs*18 | Q8IX30 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
SCUBE3 | SNV | Missense_Mutation | c.1064N>A | p.Cys355Tyr | p.C355Y | Q8IX30 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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