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Gene: SCRN1 |
Gene summary for SCRN1 |
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Gene information | Species | Human | Gene symbol | SCRN1 | Gene ID | 9805 |
Gene name | secernin 1 | |
Gene Alias | SES1 | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A090N7T9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9805 | SCRN1 | LZE5T | Human | Esophagus | ESCC | 4.32e-02 | 2.04e-01 | 0.0514 |
9805 | SCRN1 | LZE24T | Human | Esophagus | ESCC | 8.53e-11 | 4.41e-01 | 0.0596 |
9805 | SCRN1 | P1T-E | Human | Esophagus | ESCC | 2.14e-04 | 3.27e-01 | 0.0875 |
9805 | SCRN1 | P2T-E | Human | Esophagus | ESCC | 3.41e-24 | 3.14e-01 | 0.1177 |
9805 | SCRN1 | P4T-E | Human | Esophagus | ESCC | 1.18e-10 | 1.31e-01 | 0.1323 |
9805 | SCRN1 | P8T-E | Human | Esophagus | ESCC | 3.18e-21 | 3.55e-01 | 0.0889 |
9805 | SCRN1 | P9T-E | Human | Esophagus | ESCC | 6.88e-10 | 1.55e-01 | 0.1131 |
9805 | SCRN1 | P10T-E | Human | Esophagus | ESCC | 3.71e-18 | 3.99e-01 | 0.116 |
9805 | SCRN1 | P11T-E | Human | Esophagus | ESCC | 8.25e-12 | 6.02e-01 | 0.1426 |
9805 | SCRN1 | P12T-E | Human | Esophagus | ESCC | 4.08e-19 | 2.81e-01 | 0.1122 |
9805 | SCRN1 | P15T-E | Human | Esophagus | ESCC | 4.11e-08 | 9.88e-02 | 0.1149 |
9805 | SCRN1 | P16T-E | Human | Esophagus | ESCC | 1.21e-33 | 2.59e-01 | 0.1153 |
9805 | SCRN1 | P17T-E | Human | Esophagus | ESCC | 4.03e-03 | 2.83e-01 | 0.1278 |
9805 | SCRN1 | P19T-E | Human | Esophagus | ESCC | 7.93e-05 | 4.41e-01 | 0.1662 |
9805 | SCRN1 | P20T-E | Human | Esophagus | ESCC | 3.96e-09 | 2.04e-01 | 0.1124 |
9805 | SCRN1 | P21T-E | Human | Esophagus | ESCC | 8.23e-16 | 3.51e-01 | 0.1617 |
9805 | SCRN1 | P22T-E | Human | Esophagus | ESCC | 2.36e-30 | 4.48e-01 | 0.1236 |
9805 | SCRN1 | P23T-E | Human | Esophagus | ESCC | 2.04e-06 | 1.66e-01 | 0.108 |
9805 | SCRN1 | P26T-E | Human | Esophagus | ESCC | 7.94e-27 | 2.86e-01 | 0.1276 |
9805 | SCRN1 | P27T-E | Human | Esophagus | ESCC | 6.11e-25 | 2.91e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCRN1 | SNV | Missense_Mutation | novel | c.1084N>A | p.Asp362Asn | p.D362N | Q12765 | protein_coding | deleterious(0.04) | benign(0.089) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SCRN1 | SNV | Missense_Mutation | c.118G>A | p.Gly40Ser | p.G40S | Q12765 | protein_coding | tolerated(0.22) | benign(0.377) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCRN1 | SNV | Missense_Mutation | c.1063N>G | p.Pro355Ala | p.P355A | Q12765 | protein_coding | deleterious(0) | benign(0.213) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SCRN1 | insertion | Frame_Shift_Ins | novel | c.1189_1190insTCTGTCATTTATTGGGGAAGGTCTTC | p.Lys397IlefsTer20 | p.K397Ifs*20 | Q12765 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
SCRN1 | deletion | Frame_Shift_Del | novel | c.792delN | p.Lys264AsnfsTer11 | p.K264Nfs*11 | Q12765 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SCRN1 | SNV | Missense_Mutation | novel | c.1087C>T | p.Arg363Cys | p.R363C | Q12765 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SCRN1 | SNV | Missense_Mutation | novel | c.383N>C | p.Leu128Pro | p.L128P | Q12765 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EA-A5ZE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SCRN1 | SNV | Missense_Mutation | novel | c.1121N>T | p.Ala374Val | p.A374V | Q12765 | protein_coding | tolerated(0.06) | benign(0.303) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SCRN1 | SNV | Missense_Mutation | novel | c.1156N>T | p.Arg386Cys | p.R386C | Q12765 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SCRN1 | SNV | Missense_Mutation | rs766147656 | c.1114N>A | p.Glu372Lys | p.E372K | Q12765 | protein_coding | deleterious(0.05) | benign(0.043) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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