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Gene: SCPEP1 |
Gene summary for SCPEP1 |
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Gene information | Species | Human | Gene symbol | SCPEP1 | Gene ID | 59342 |
Gene name | serine carboxypeptidase 1 | |
Gene Alias | HSCP1 | |
Cytomap | 17q22 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | Q9H2J9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59342 | SCPEP1 | LZE4T | Human | Esophagus | ESCC | 2.90e-10 | 1.62e-01 | 0.0811 |
59342 | SCPEP1 | LZE8T | Human | Esophagus | ESCC | 3.70e-06 | 6.99e-01 | 0.067 |
59342 | SCPEP1 | LZE20T | Human | Esophagus | ESCC | 1.99e-02 | 1.30e-01 | 0.0662 |
59342 | SCPEP1 | LZE21D1 | Human | Esophagus | HGIN | 4.81e-05 | 7.92e-01 | 0.0632 |
59342 | SCPEP1 | LZE24T | Human | Esophagus | ESCC | 8.14e-19 | -1.09e-01 | 0.0596 |
59342 | SCPEP1 | LZE21T | Human | Esophagus | ESCC | 3.63e-02 | 8.90e-01 | 0.0655 |
59342 | SCPEP1 | P1T-E | Human | Esophagus | ESCC | 3.41e-03 | 9.07e-01 | 0.0875 |
59342 | SCPEP1 | P2T-E | Human | Esophagus | ESCC | 8.31e-70 | 1.89e+00 | 0.1177 |
59342 | SCPEP1 | P4T-E | Human | Esophagus | ESCC | 1.87e-19 | 1.13e+00 | 0.1323 |
59342 | SCPEP1 | P5T-E | Human | Esophagus | ESCC | 6.91e-14 | -1.11e-01 | 0.1327 |
59342 | SCPEP1 | P8T-E | Human | Esophagus | ESCC | 1.45e-76 | 2.30e+00 | 0.0889 |
59342 | SCPEP1 | P9T-E | Human | Esophagus | ESCC | 2.06e-06 | 3.81e-01 | 0.1131 |
59342 | SCPEP1 | P10T-E | Human | Esophagus | ESCC | 3.20e-41 | 1.43e+00 | 0.116 |
59342 | SCPEP1 | P11T-E | Human | Esophagus | ESCC | 2.90e-17 | 1.49e+00 | 0.1426 |
59342 | SCPEP1 | P12T-E | Human | Esophagus | ESCC | 1.03e-45 | 1.41e+00 | 0.1122 |
59342 | SCPEP1 | P15T-E | Human | Esophagus | ESCC | 1.86e-48 | 1.97e+00 | 0.1149 |
59342 | SCPEP1 | P16T-E | Human | Esophagus | ESCC | 2.23e-51 | 1.47e+00 | 0.1153 |
59342 | SCPEP1 | P20T-E | Human | Esophagus | ESCC | 4.21e-19 | 8.97e-01 | 0.1124 |
59342 | SCPEP1 | P21T-E | Human | Esophagus | ESCC | 3.94e-40 | 1.19e+00 | 0.1617 |
59342 | SCPEP1 | P22T-E | Human | Esophagus | ESCC | 1.02e-63 | 1.64e+00 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000672011 | Liver | HCC | isoprenoid metabolic process | 65/7958 | 116/18723 | 2.23e-03 | 1.11e-02 | 65 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:00030183 | Prostate | Tumor | vascular process in circulatory system | 61/3246 | 263/18723 | 8.88e-03 | 3.84e-02 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCPEP1 | SNV | Missense_Mutation | novel | c.492N>A | p.Phe164Leu | p.F164L | Q9HB40 | protein_coding | tolerated(0.05) | possibly_damaging(0.802) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCPEP1 | SNV | Missense_Mutation | c.194T>A | p.Phe65Tyr | p.F65Y | Q9HB40 | protein_coding | tolerated(1) | benign(0.026) | TCGA-E2-A150-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SCPEP1 | insertion | Frame_Shift_Ins | novel | c.498_499insAGCTGGGACTACAGGCGCCCGCCAC | p.Tyr168TrpfsTer23 | p.Y168Wfs*23 | Q9HB40 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SCPEP1 | insertion | Frame_Shift_Ins | novel | c.610_611insG | p.Ser204CysfsTer4 | p.S204Cfs*4 | Q9HB40 | protein_coding | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
SCPEP1 | insertion | In_Frame_Ins | novel | c.613_614insAGGCTAGCCTCGACCTCCTGGGGTCAAGTGATC | p.Ser204_Pro205insGlnAlaSerLeuAspLeuLeuGlySerSerAsp | p.S204_P205insQASLDLLGSSD | Q9HB40 | protein_coding | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
SCPEP1 | SNV | Missense_Mutation | c.23N>T | p.Ser8Phe | p.S8F | Q9HB40 | protein_coding | tolerated_low_confidence(0.67) | benign(0) | TCGA-DG-A2KH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SCPEP1 | SNV | Missense_Mutation | c.88G>C | p.Asp30His | p.D30H | Q9HB40 | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SCPEP1 | SNV | Missense_Mutation | rs769859901 | c.1174N>T | p.Pro392Ser | p.P392S | Q9HB40 | protein_coding | tolerated(0.63) | benign(0.005) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCPEP1 | SNV | Missense_Mutation | rs377343195 | c.1201N>A | p.Ala401Thr | p.A401T | Q9HB40 | protein_coding | deleterious(0.04) | benign(0.428) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCPEP1 | SNV | Missense_Mutation | rs771883135 | c.1150N>T | p.Arg384Trp | p.R384W | Q9HB40 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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