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Gene: SCG3 |
Gene summary for SCG3 |
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Gene information | Species | Human | Gene symbol | SCG3 | Gene ID | 29106 |
Gene name | secretogranin III | |
Gene Alias | SGIII | |
Cytomap | 15q21.2 | |
Gene Type | protein-coding | GO ID | GO:0008104 | UniProtAcc | Q8WXD2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29106 | SCG3 | S014 | Human | Liver | HCC | 3.91e-17 | 8.50e-01 | 0.2254 |
29106 | SCG3 | S015 | Human | Liver | HCC | 5.98e-31 | 2.19e+00 | 0.2375 |
29106 | SCG3 | S016 | Human | Liver | HCC | 3.86e-45 | 1.59e+00 | 0.2243 |
29106 | SCG3 | HTA12-15-2 | Human | Pancreas | PDAC | 3.78e-09 | 6.52e-01 | 0.2315 |
29106 | SCG3 | HTA12-23-1 | Human | Pancreas | PDAC | 2.25e-04 | 5.34e-01 | 0.3405 |
29106 | SCG3 | HTA12-26-1 | Human | Pancreas | PDAC | 4.88e-07 | 3.79e-01 | 0.3728 |
29106 | SCG3 | HTA12-29-1 | Human | Pancreas | PDAC | 1.94e-18 | 4.40e-01 | 0.3722 |
29106 | SCG3 | HTA12-9-3 | Human | Pancreas | PDAC | 8.76e-04 | 5.55e-01 | 0.2045 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCG3 | SNV | Missense_Mutation | c.700G>T | p.Ala234Ser | p.A234S | Q8WXD2 | protein_coding | tolerated_low_confidence(0.71) | benign(0.347) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
SCG3 | SNV | Missense_Mutation | c.310A>G | p.Asn104Asp | p.N104D | Q8WXD2 | protein_coding | tolerated_low_confidence(0.39) | benign(0.215) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCG3 | SNV | Missense_Mutation | rs768697386 | c.442N>A | p.Ala148Thr | p.A148T | Q8WXD2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
SCG3 | SNV | Missense_Mutation | c.1055G>T | p.Ser352Ile | p.S352I | Q8WXD2 | protein_coding | tolerated_low_confidence(0.06) | benign(0.012) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
SCG3 | SNV | Missense_Mutation | c.1328A>G | p.Gln443Arg | p.Q443R | Q8WXD2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.986) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SCG3 | SNV | Missense_Mutation | c.770A>C | p.Asn257Thr | p.N257T | Q8WXD2 | protein_coding | tolerated_low_confidence(0.08) | benign(0.003) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SCG3 | SNV | Missense_Mutation | novel | c.1316N>C | p.Phe439Ser | p.F439S | Q8WXD2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCG3 | SNV | Missense_Mutation | c.1087N>A | p.His363Asn | p.H363N | Q8WXD2 | protein_coding | tolerated_low_confidence(0.31) | benign(0.023) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SCG3 | SNV | Missense_Mutation | c.1202N>A | p.Pro401His | p.P401H | Q8WXD2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.003) | TCGA-AD-6888-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
SCG3 | SNV | Missense_Mutation | novel | c.362N>C | p.Asp121Ala | p.D121A | Q8WXD2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.913) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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