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Gene: SAP130 |
Gene summary for SAP130 |
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Gene information | Species | Human | Gene symbol | SAP130 | Gene ID | 79595 |
Gene name | Sin3A associated protein 130 | |
Gene Alias | SAP130 | |
Cytomap | 2q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H0E3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79595 | SAP130 | HCC1_Meng | Human | Liver | HCC | 3.94e-17 | -5.59e-04 | 0.0246 |
79595 | SAP130 | HCC1 | Human | Liver | HCC | 1.70e-03 | 2.99e+00 | 0.5336 |
79595 | SAP130 | HCC2 | Human | Liver | HCC | 1.18e-07 | 3.08e+00 | 0.5341 |
79595 | SAP130 | S014 | Human | Liver | HCC | 2.96e-07 | 2.64e-01 | 0.2254 |
79595 | SAP130 | S015 | Human | Liver | HCC | 8.77e-05 | 2.91e-01 | 0.2375 |
79595 | SAP130 | S016 | Human | Liver | HCC | 5.36e-08 | 2.75e-01 | 0.2243 |
79595 | SAP130 | S027 | Human | Liver | HCC | 1.68e-03 | 3.71e-01 | 0.2446 |
79595 | SAP130 | S028 | Human | Liver | HCC | 1.18e-09 | 4.05e-01 | 0.2503 |
79595 | SAP130 | S029 | Human | Liver | HCC | 1.51e-03 | 2.65e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAP130 | SNV | Missense_Mutation | novel | c.2410N>A | p.Gly804Ser | p.G804S | Q9H0E3 | protein_coding | tolerated_low_confidence(1) | benign(0.001) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SAP130 | SNV | Missense_Mutation | rs778136320 | c.2981N>T | p.Thr994Met | p.T994M | Q9H0E3 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.911) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD |
SAP130 | SNV | Missense_Mutation | c.2229N>T | p.Gln743His | p.Q743H | Q9H0E3 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.991) | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
SAP130 | deletion | In_Frame_Del | c.474_476delNNN | p.Pro159del | p.P159del | Q9H0E3 | protein_coding | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SAP130 | SNV | Missense_Mutation | novel | c.2507C>T | p.Pro836Leu | p.P836L | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.866) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SAP130 | SNV | Missense_Mutation | c.284C>A | p.Pro95His | p.P95H | Q9H0E3 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.98) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SAP130 | SNV | Missense_Mutation | c.2158N>A | p.Glu720Lys | p.E720K | Q9H0E3 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.717) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAP130 | SNV | Missense_Mutation | novel | c.457N>T | p.Pro153Ser | p.P153S | Q9H0E3 | protein_coding | deleterious_low_confidence(0.05) | possibly_damaging(0.898) | TCGA-C5-A2M1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SAP130 | SNV | Missense_Mutation | rs781471032 | c.1618G>A | p.Val540Ile | p.V540I | Q9H0E3 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.728) | TCGA-DS-A5RQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
SAP130 | SNV | Missense_Mutation | c.307N>G | p.Gln103Glu | p.Q103E | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79595 | SAP130 | NA | SPLICEOSTATIN-A | CHEMBL1221944 | 17643111 |
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