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Gene: SAMD5 |
Gene summary for SAMD5 |
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Gene information | Species | Human | Gene symbol | SAMD5 | Gene ID | 389432 |
Gene name | sterile alpha motif domain containing 5 | |
Gene Alias | dJ875H10.1 | |
Cytomap | 6q24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5TGI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389432 | SAMD5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.68e-04 | -6.26e-01 | -0.1808 |
389432 | SAMD5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.09e-04 | -5.05e-01 | -0.2196 |
389432 | SAMD5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.06e-02 | -7.54e-01 | -0.2061 |
389432 | SAMD5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.87e-05 | -3.19e-01 | 0.0674 |
389432 | SAMD5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.27e-08 | -3.95e-01 | 0.294 |
389432 | SAMD5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.94e-03 | 9.27e-01 | 0.3487 |
389432 | SAMD5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.86e-23 | 1.28e+00 | 0.281 |
389432 | SAMD5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.51e-15 | -5.72e-01 | 0.3859 |
389432 | SAMD5 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.26e-07 | -8.21e-01 | 0.2585 |
389432 | SAMD5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.12e-06 | -3.90e-01 | 0.3005 |
389432 | SAMD5 | F007 | Human | Colorectum | FAP | 4.68e-03 | 2.85e-01 | 0.1176 |
389432 | SAMD5 | A002-C-010 | Human | Colorectum | FAP | 3.86e-25 | 5.51e-01 | 0.242 |
389432 | SAMD5 | A015-C-203 | Human | Colorectum | FAP | 6.56e-23 | -3.35e-01 | -0.1294 |
389432 | SAMD5 | A015-C-204 | Human | Colorectum | FAP | 3.41e-03 | -3.91e-01 | -0.0228 |
389432 | SAMD5 | A002-C-201 | Human | Colorectum | FAP | 1.09e-07 | 1.06e-01 | 0.0324 |
389432 | SAMD5 | A002-C-203 | Human | Colorectum | FAP | 3.62e-08 | 4.57e-01 | 0.2786 |
389432 | SAMD5 | A001-C-119 | Human | Colorectum | FAP | 1.36e-10 | -6.75e-01 | -0.1557 |
389432 | SAMD5 | A001-C-108 | Human | Colorectum | FAP | 1.17e-13 | -8.48e-02 | -0.0272 |
389432 | SAMD5 | A002-C-021 | Human | Colorectum | FAP | 2.05e-18 | 6.13e-01 | 0.1171 |
389432 | SAMD5 | A002-C-205 | Human | Colorectum | FAP | 1.88e-14 | -3.70e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAMD5 | SNV | Missense_Mutation | novel | c.399N>T | p.Met133Ile | p.M133I | Q5TGI4 | protein_coding | tolerated(0.18) | possibly_damaging(0.878) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SAMD5 | deletion | Frame_Shift_Del | novel | c.284delN | p.Glu97SerfsTer27 | p.E97Sfs*27 | Q5TGI4 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SAMD5 | SNV | Missense_Mutation | novel | c.59N>G | p.Glu20Gly | p.E20G | Q5TGI4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAMD5 | SNV | Missense_Mutation | novel | c.478C>A | p.Leu160Ile | p.L160I | Q5TGI4 | protein_coding | tolerated(0.29) | probably_damaging(0.952) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAMD5 | SNV | Missense_Mutation | novel | c.175N>A | p.Val59Met | p.V59M | Q5TGI4 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EY-A548-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAMD5 | SNV | Missense_Mutation | novel | c.75C>A | p.Asn25Lys | p.N25K | Q5TGI4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DD-A39W-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SAMD5 | SNV | Missense_Mutation | novel | c.195G>C | p.Gln65His | p.Q65H | Q5TGI4 | protein_coding | deleterious(0.03) | possibly_damaging(0.496) | TCGA-MI-A75G-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SAMD5 | SNV | Missense_Mutation | novel | c.332G>A | p.Arg111His | p.R111H | Q5TGI4 | protein_coding | tolerated(0.28) | possibly_damaging(0.451) | TCGA-CN-A499-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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