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Gene: S100A13 |
Gene summary for S100A13 |
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Gene information | Species | Human | Gene symbol | S100A13 | Gene ID | 6284 |
Gene name | S100 calcium binding protein A13 | |
Gene Alias | S100A13 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q99584 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6284 | S100A13 | GSM4909281 | Human | Breast | IDC | 1.94e-02 | 2.53e-01 | 0.21 |
6284 | S100A13 | GSM4909282 | Human | Breast | IDC | 2.81e-04 | -3.46e-01 | -0.0288 |
6284 | S100A13 | GSM4909285 | Human | Breast | IDC | 5.82e-05 | 3.33e-01 | 0.21 |
6284 | S100A13 | GSM4909286 | Human | Breast | IDC | 1.19e-06 | 2.63e-01 | 0.1081 |
6284 | S100A13 | GSM4909287 | Human | Breast | IDC | 2.98e-16 | 3.64e-01 | 0.2057 |
6284 | S100A13 | GSM4909288 | Human | Breast | IDC | 5.88e-05 | -6.90e-02 | 0.0988 |
6284 | S100A13 | GSM4909294 | Human | Breast | IDC | 2.14e-10 | 6.52e-02 | 0.2022 |
6284 | S100A13 | GSM4909296 | Human | Breast | IDC | 4.92e-19 | -2.98e-01 | 0.1524 |
6284 | S100A13 | GSM4909297 | Human | Breast | IDC | 1.20e-34 | 1.92e-01 | 0.1517 |
6284 | S100A13 | GSM4909299 | Human | Breast | IDC | 4.91e-13 | 4.40e-01 | 0.035 |
6284 | S100A13 | GSM4909301 | Human | Breast | IDC | 5.56e-22 | -5.45e-01 | 0.1577 |
6284 | S100A13 | GSM4909302 | Human | Breast | IDC | 8.37e-09 | 2.03e-01 | 0.1545 |
6284 | S100A13 | GSM4909304 | Human | Breast | IDC | 1.96e-34 | 6.06e-01 | 0.1636 |
6284 | S100A13 | GSM4909306 | Human | Breast | IDC | 2.86e-18 | 4.68e-01 | 0.1564 |
6284 | S100A13 | GSM4909307 | Human | Breast | IDC | 3.08e-30 | 5.69e-01 | 0.1569 |
6284 | S100A13 | GSM4909308 | Human | Breast | IDC | 3.24e-18 | 4.38e-01 | 0.158 |
6284 | S100A13 | GSM4909309 | Human | Breast | IDC | 2.99e-08 | 1.49e-01 | 0.0483 |
6284 | S100A13 | GSM4909311 | Human | Breast | IDC | 7.69e-49 | -2.88e-01 | 0.1534 |
6284 | S100A13 | GSM4909312 | Human | Breast | IDC | 9.82e-15 | -2.67e-01 | 0.1552 |
6284 | S100A13 | GSM4909313 | Human | Breast | IDC | 2.35e-20 | 2.67e-01 | 0.0391 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:0032732 | Breast | Precancer | positive regulation of interleukin-1 production | 11/1080 | 73/18723 | 2.96e-03 | 2.55e-02 | 11 |
GO:00072496 | Breast | Precancer | I-kappaB kinase/NF-kappaB signaling | 27/1080 | 281/18723 | 6.58e-03 | 4.53e-02 | 27 |
GO:000181911 | Breast | IDC | positive regulation of cytokine production | 61/1434 | 467/18723 | 2.81e-05 | 6.58e-04 | 61 |
GO:00431227 | Breast | IDC | regulation of I-kappaB kinase/NF-kappaB signaling | 34/1434 | 249/18723 | 7.18e-04 | 8.77e-03 | 34 |
GO:000724914 | Breast | IDC | I-kappaB kinase/NF-kappaB signaling | 37/1434 | 281/18723 | 8.58e-04 | 9.98e-03 | 37 |
GO:00431236 | Breast | IDC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 26/1434 | 186/18723 | 2.06e-03 | 1.95e-02 | 26 |
GO:000181921 | Breast | DCIS | positive regulation of cytokine production | 63/1390 | 467/18723 | 2.76e-06 | 9.42e-05 | 63 |
GO:004312214 | Breast | DCIS | regulation of I-kappaB kinase/NF-kappaB signaling | 32/1390 | 249/18723 | 1.67e-03 | 1.66e-02 | 32 |
GO:000724923 | Breast | DCIS | I-kappaB kinase/NF-kappaB signaling | 35/1390 | 281/18723 | 1.80e-03 | 1.74e-02 | 35 |
GO:00327321 | Breast | DCIS | positive regulation of interleukin-1 production | 13/1390 | 73/18723 | 2.57e-03 | 2.30e-02 | 13 |
GO:00022742 | Breast | DCIS | myeloid leukocyte activation | 28/1390 | 223/18723 | 4.37e-03 | 3.41e-02 | 28 |
GO:004312313 | Breast | DCIS | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24/1390 | 186/18723 | 5.66e-03 | 4.09e-02 | 24 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0043123 | Colorectum | AD | positive regulation of I-kappaB kinase/NF-kappaB signaling | 60/3918 | 186/18723 | 1.91e-04 | 2.56e-03 | 60 |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A13 | SNV | Missense_Mutation | c.257A>G | p.Glu86Gly | p.E86G | Q99584 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100A13 | SNV | Missense_Mutation | rs373852522 | c.103N>A | p.Val35Ile | p.V35I | Q99584 | protein_coding | tolerated(0.7) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A13 | SNV | Missense_Mutation | c.86N>A | p.Arg29Gln | p.R29Q | Q99584 | protein_coding | tolerated(0.51) | benign(0.141) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S100A13 | SNV | Missense_Mutation | novel | c.53N>T | p.Thr18Ile | p.T18I | Q99584 | protein_coding | deleterious(0.04) | benign(0.31) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A13 | SNV | Missense_Mutation | c.158T>C | p.Val53Ala | p.V53A | Q99584 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
S100A13 | SNV | Missense_Mutation | rs369833765 | c.109N>A | p.Glu37Lys | p.E37K | Q99584 | protein_coding | deleterious(0.05) | benign(0.201) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
S100A13 | SNV | Missense_Mutation | c.274N>C | p.Asp92His | p.D92H | Q99584 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100A13 | SNV | Missense_Mutation | c.86G>A | p.Arg29Gln | p.R29Q | Q99584 | protein_coding | tolerated(0.51) | benign(0.141) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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