Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: S100A10

Gene summary for S100A10

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

S100A10

Gene ID

6281

Gene nameS100 calcium binding protein A10
Gene Alias42C
Cytomap1q21.3
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

P60903


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6281S100A10GSM4909281HumanBreastIDC5.97e-083.56e-010.21
6281S100A10GSM4909282HumanBreastIDC1.01e-477.31e-01-0.0288
6281S100A10GSM4909285HumanBreastIDC9.62e-154.98e-010.21
6281S100A10GSM4909286HumanBreastIDC4.08e-25-8.65e-010.1081
6281S100A10GSM4909290HumanBreastIDC7.88e-032.24e-010.2096
6281S100A10GSM4909293HumanBreastIDC5.88e-15-5.17e-010.1581
6281S100A10GSM4909297HumanBreastIDC1.54e-092.18e-010.1517
6281S100A10GSM4909298HumanBreastIDC1.68e-25-7.93e-010.1551
6281S100A10GSM4909299HumanBreastIDC1.11e-026.45e-030.035
6281S100A10GSM4909301HumanBreastIDC8.34e-47-1.05e+000.1577
6281S100A10GSM4909303HumanBreastIDC4.94e-04-7.06e-010.0438
6281S100A10GSM4909304HumanBreastIDC1.95e-05-1.45e-010.1636
6281S100A10GSM4909305HumanBreastIDC1.13e-02-4.62e-020.0436
6281S100A10GSM4909308HumanBreastIDC5.27e-22-8.39e-010.158
6281S100A10GSM4909311HumanBreastIDC2.57e-21-5.51e-010.1534
6281S100A10GSM4909312HumanBreastIDC3.91e-16-5.88e-010.1552
6281S100A10GSM4909315HumanBreastIDC1.02e-1391.13e+000.21
6281S100A10GSM4909316HumanBreastIDC2.73e-339.30e-010.21
6281S100A10GSM4909319HumanBreastIDC2.14e-34-7.44e-010.1563
6281S100A10GSM4909321HumanBreastIDC2.80e-02-2.89e-010.1559
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00457859BreastPrecancerpositive regulation of cell adhesion52/1080437/187235.74e-072.49e-0552
GO:00510989BreastPrecancerregulation of binding44/1080363/187232.59e-068.65e-0544
GO:19029059BreastPrecancerpositive regulation of supramolecular fiber organization28/1080209/187232.79e-056.28e-0428
GO:19029039BreastPrecancerregulation of supramolecular fiber organization42/1080383/187234.92e-051.04e-0342
GO:00329709BreastPrecancerregulation of actin filament-based process42/1080397/187231.11e-042.01e-0342
GO:00514959BreastPrecancerpositive regulation of cytoskeleton organization28/1080226/187231.13e-042.04e-0328
GO:00510999BreastPrecancerpositive regulation of binding23/1080173/187231.58e-042.68e-0323
GO:00069009BreastPrecancervesicle budding from membrane12/108061/187231.61e-042.69e-0312
GO:00070159BreastPrecanceractin filament organization44/1080442/187233.02e-044.35e-0344
GO:00094108BreastPrecancerresponse to xenobiotic stimulus45/1080462/187234.17e-045.56e-0345
GO:01501174BreastPrecancerpositive regulation of cell-substrate junction organization8/108033/187234.55e-046.02e-038
GO:00329569BreastPrecancerregulation of actin cytoskeleton organization36/1080358/187238.56e-049.88e-0336
GO:01100539BreastPrecancerregulation of actin filament organization29/1080278/187231.50e-031.55e-0229
GO:19000268BreastPrecancerpositive regulation of substrate adhesion-dependent cell spreading8/108041/187232.08e-031.97e-028
GO:00514929BreastPrecancerregulation of stress fiber assembly13/108091/187232.11e-032.00e-0213
GO:00315794BreastPrecancermembrane raft organization6/108025/187232.49e-032.28e-026
GO:00514965BreastPrecancerpositive regulation of stress fiber assembly9/108052/187232.67e-032.36e-029
GO:00322338BreastPrecancerpositive regulation of actin filament bundle assembly10/108063/187233.07e-032.62e-0210
GO:00300389BreastPrecancercontractile actin filament bundle assembly14/1080106/187233.07e-032.62e-0214
GO:00431499BreastPrecancerstress fiber assembly14/1080106/187233.07e-032.62e-0214
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513218BreastPrecancerSalmonella infection49/684249/84652.92e-096.15e-084.71e-0849
hsa0513219BreastPrecancerSalmonella infection49/684249/84652.92e-096.15e-084.71e-0849
hsa0513224BreastIDCSalmonella infection55/867249/84652.07e-084.49e-073.36e-0755
hsa0513234BreastIDCSalmonella infection55/867249/84652.07e-084.49e-073.36e-0755
hsa0513243BreastDCISSalmonella infection55/846249/84658.71e-091.87e-071.38e-0755
hsa0513253BreastDCISSalmonella infection55/846249/84658.71e-091.87e-071.38e-0755
hsa0513220CervixCCSalmonella infection74/1267249/84651.33e-092.54e-081.50e-0874
hsa05132110CervixCCSalmonella infection74/1267249/84651.33e-092.54e-081.50e-0874
hsa0513244CervixN_HPVSalmonella infection28/349249/84651.18e-061.64e-051.28e-0528
hsa0513254CervixN_HPVSalmonella infection28/349249/84651.18e-061.64e-051.28e-0528
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa051322ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa051323ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa051324ColorectumMSSSalmonella infection92/1875249/84655.23e-089.74e-075.97e-0792
hsa051325ColorectumMSSSalmonella infection92/1875249/84655.23e-089.74e-075.97e-0792
hsa051326ColorectumMSI-HSalmonella infection43/797249/84655.91e-058.33e-046.98e-0443
hsa051327ColorectumMSI-HSalmonella infection43/797249/84655.91e-058.33e-046.98e-0443
hsa051328ColorectumFAPSalmonella infection67/1404249/84652.04e-052.52e-041.53e-0467
hsa051329ColorectumFAPSalmonella infection67/1404249/84652.04e-052.52e-041.53e-0467
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
S100A10SNVMissense_Mutationc.104N>Gp.Met35Argp.M35RP60903protein_codingdeleterious(0.01)benign(0.424)TCGA-AR-A0TP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
S100A10SNVMissense_Mutationnovelc.224N>Gp.Leu75Argp.L75RP60903protein_codingdeleterious(0.02)probably_damaging(0.981)TCGA-AJ-A8CW-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
S100A10SNVMissense_Mutationrs11542012c.230N>Tp.Ala77Valp.A77VP60903protein_codingtolerated(0.3)benign(0.104)TCGA-AX-A0J1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
S100A10SNVMissense_Mutationrs374528021c.211N>Gp.Ser71Glyp.S71GP60903protein_codingtolerated(0.15)benign(0.001)TCGA-BS-A0UJ-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
S100A10SNVMissense_Mutationnovelc.216C>Ap.Phe72Leup.F72LP60903protein_codingtolerated(0.1)benign(0.132)TCGA-D1-A17Q-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
S100A10SNVMissense_Mutationnovelc.183N>Tp.Gln61Hisp.Q61HP60903protein_codingdeleterious(0.03)benign(0.013)TCGA-CV-6937-01Oral cavityhead & neck squamous cell carcinomaMale>=65I/IIUnknownUnknownSD
S100A10SNVMissense_Mutationnovelc.250A>Tp.Asn84Tyrp.N84YP60903protein_codingdeleterious(0.02)possibly_damaging(0.703)TCGA-UF-A7JV-01Oral cavityhead & neck squamous cell carcinomaFemale<65I/IIUnknownUnknownPD
S100A10insertionFrame_Shift_Insnovelc.265_266insGGTACATGTGTATAACGCGCAGGTTTGTp.Val89GlyfsTer29p.V89Gfs*29P60903protein_codingTCGA-CG-4440-01Stomachstomach adenocarcinomaFemale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6281S100A10KINASEGONADOTROPINS11356677
6281S100A10KINASEDEXAMETHASONEDEXAMETHASONE10358078
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