Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: RXYLT1

Gene summary for RXYLT1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RXYLT1

Gene ID

10329

Gene nameribitol xylosyltransferase 1
Gene AliasHP10481
Cytomap12q14.2
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

G3V1K2


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10329RXYLT1NAFLD1HumanLiverNAFLD1.48e-022.47e-01-0.04
10329RXYLT1S014HumanLiverHCC1.07e-255.62e-010.2254
10329RXYLT1S015HumanLiverHCC1.17e-216.20e-010.2375
10329RXYLT1S016HumanLiverHCC5.17e-215.34e-010.2243
10329RXYLT1S027HumanLiverHCC2.91e-178.12e-010.2446
10329RXYLT1S028HumanLiverHCC1.74e-318.34e-010.2503
10329RXYLT1S029HumanLiverHCC1.76e-256.71e-010.2581
10329RXYLT1male-WTAHumanThyroidPTC2.71e-091.77e-010.1037
10329RXYLT1PTC01HumanThyroidPTC1.02e-183.07e-010.1899
10329RXYLT1PTC04HumanThyroidPTC5.88e-091.92e-010.1927
10329RXYLT1PTC05HumanThyroidPTC2.27e-124.15e-010.2065
10329RXYLT1PTC06HumanThyroidPTC3.68e-174.65e-010.2057
10329RXYLT1PTC07HumanThyroidPTC6.62e-355.65e-010.2044
10329RXYLT1ATC09HumanThyroidATC9.00e-082.94e-010.2871
10329RXYLT1ATC11HumanThyroidATC2.49e-065.38e-010.3386
10329RXYLT1ATC12HumanThyroidATC1.68e-153.92e-010.34
10329RXYLT1ATC13HumanThyroidATC6.16e-275.30e-010.34
10329RXYLT1ATC1HumanThyroidATC1.26e-093.97e-010.2878
10329RXYLT1ATC2HumanThyroidATC1.60e-078.27e-010.34
10329RXYLT1ATC3HumanThyroidATC6.43e-043.48e-010.338
Page: 1 2 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00064862LiverHCCprotein glycosylation122/7958226/187233.11e-042.21e-03122
GO:00434132LiverHCCmacromolecule glycosylation122/7958226/187233.11e-042.21e-03122
GO:00700852LiverHCCglycosylation128/7958240/187234.35e-042.92e-03128
GO:0009100LiverHCCglycoprotein metabolic process193/7958387/187231.89e-039.62e-03193
GO:00064866ThyroidPTCprotein glycosylation94/5968226/187231.25e-037.13e-0394
GO:00434136ThyroidPTCmacromolecule glycosylation94/5968226/187231.25e-037.13e-0394
GO:00700855ThyroidPTCglycosylation96/5968240/187234.57e-032.15e-0296
GO:00091013ThyroidPTCglycoprotein biosynthetic process123/5968317/187235.05e-032.33e-02123
GO:00091003ThyroidPTCglycoprotein metabolic process147/5968387/187235.87e-032.64e-02147
GO:000648612ThyroidATCprotein glycosylation94/6293226/187237.11e-032.82e-0294
GO:004341312ThyroidATCmacromolecule glycosylation94/6293226/187237.11e-032.82e-0294
GO:000910011ThyroidATCglycoprotein metabolic process153/6293387/187237.90e-033.06e-02153
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
Page: 1 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1