![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RUFY1 |
Gene summary for RUFY1 |
![]() |
Gene information | Species | Human | Gene symbol | RUFY1 | Gene ID | 80230 |
Gene name | RUN and FYVE domain containing 1 | |
Gene Alias | RABIP4 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A8K7B1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80230 | RUFY1 | LZE24T | Human | Esophagus | ESCC | 9.48e-08 | 2.55e-01 | 0.0596 |
80230 | RUFY1 | P1T-E | Human | Esophagus | ESCC | 5.59e-03 | 1.54e-01 | 0.0875 |
80230 | RUFY1 | P2T-E | Human | Esophagus | ESCC | 1.34e-31 | 5.02e-01 | 0.1177 |
80230 | RUFY1 | P4T-E | Human | Esophagus | ESCC | 4.52e-07 | 1.92e-01 | 0.1323 |
80230 | RUFY1 | P5T-E | Human | Esophagus | ESCC | 5.45e-14 | 2.90e-01 | 0.1327 |
80230 | RUFY1 | P8T-E | Human | Esophagus | ESCC | 1.47e-11 | 1.34e-01 | 0.0889 |
80230 | RUFY1 | P9T-E | Human | Esophagus | ESCC | 1.97e-05 | 1.33e-01 | 0.1131 |
80230 | RUFY1 | P10T-E | Human | Esophagus | ESCC | 6.47e-10 | 1.99e-01 | 0.116 |
80230 | RUFY1 | P11T-E | Human | Esophagus | ESCC | 1.03e-10 | 4.16e-01 | 0.1426 |
80230 | RUFY1 | P12T-E | Human | Esophagus | ESCC | 8.71e-09 | 1.65e-01 | 0.1122 |
80230 | RUFY1 | P15T-E | Human | Esophagus | ESCC | 4.88e-10 | 2.45e-01 | 0.1149 |
80230 | RUFY1 | P16T-E | Human | Esophagus | ESCC | 3.64e-10 | 2.48e-01 | 0.1153 |
80230 | RUFY1 | P19T-E | Human | Esophagus | ESCC | 2.29e-10 | 5.99e-01 | 0.1662 |
80230 | RUFY1 | P20T-E | Human | Esophagus | ESCC | 5.08e-04 | 1.22e-01 | 0.1124 |
80230 | RUFY1 | P21T-E | Human | Esophagus | ESCC | 1.87e-10 | 1.86e-01 | 0.1617 |
80230 | RUFY1 | P22T-E | Human | Esophagus | ESCC | 3.72e-27 | 4.52e-01 | 0.1236 |
80230 | RUFY1 | P23T-E | Human | Esophagus | ESCC | 7.09e-09 | 2.67e-01 | 0.108 |
80230 | RUFY1 | P24T-E | Human | Esophagus | ESCC | 1.26e-08 | 1.42e-01 | 0.1287 |
80230 | RUFY1 | P26T-E | Human | Esophagus | ESCC | 1.08e-09 | 1.89e-01 | 0.1276 |
80230 | RUFY1 | P27T-E | Human | Esophagus | ESCC | 4.44e-04 | 1.68e-01 | 0.1055 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:003010021 | Liver | HCC | regulation of endocytosis | 117/7958 | 211/18723 | 9.56e-05 | 8.32e-04 | 117 |
GO:003010016 | Oral cavity | OSCC | regulation of endocytosis | 121/7305 | 211/18723 | 4.74e-08 | 8.80e-07 | 121 |
GO:003010023 | Oral cavity | EOLP | regulation of endocytosis | 51/2218 | 211/18723 | 4.24e-07 | 1.19e-05 | 51 |
GO:003010024 | Skin | cSCC | regulation of endocytosis | 72/4864 | 211/18723 | 5.06e-03 | 2.56e-02 | 72 |
GO:003010020 | Thyroid | PTC | regulation of endocytosis | 108/5968 | 211/18723 | 3.92e-09 | 1.04e-07 | 108 |
GO:0030100111 | Thyroid | ATC | regulation of endocytosis | 113/6293 | 211/18723 | 1.71e-09 | 4.22e-08 | 113 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414442 | Oral cavity | EOLP | Endocytosis | 71/1218 | 251/8465 | 5.28e-09 | 8.97e-08 | 5.29e-08 | 71 |
hsa0414452 | Oral cavity | EOLP | Endocytosis | 71/1218 | 251/8465 | 5.28e-09 | 8.97e-08 | 5.29e-08 | 71 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUFY1 | SNV | Missense_Mutation | c.1402N>T | p.His468Tyr | p.H468Y | Q96T51 | protein_coding | deleterious(0.04) | benign(0.405) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
RUFY1 | SNV | Missense_Mutation | rs767996315 | c.623G>A | p.Arg208Gln | p.R208Q | Q96T51 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUFY1 | SNV | Missense_Mutation | c.862N>T | p.Asp288Tyr | p.D288Y | Q96T51 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
RUFY1 | SNV | Missense_Mutation | rs368354140 | c.1768N>T | p.Arg590Trp | p.R590W | Q96T51 | protein_coding | deleterious(0.02) | possibly_damaging(0.462) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
RUFY1 | SNV | Missense_Mutation | novel | c.829G>A | p.Val277Ile | p.V277I | Q96T51 | protein_coding | tolerated(0.05) | benign(0.15) | TCGA-EW-A6SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | aromatase | SD |
RUFY1 | SNV | Missense_Mutation | c.1126N>C | p.Glu376Gln | p.E376Q | Q96T51 | protein_coding | deleterious(0.05) | possibly_damaging(0.677) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
RUFY1 | SNV | Missense_Mutation | novel | c.847N>C | p.Ser283Pro | p.S283P | Q96T51 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUFY1 | deletion | Frame_Shift_Del | c.395_396delNN | p.Leu132GlnfsTer31 | p.L132Qfs*31 | Q96T51 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RUFY1 | insertion | Frame_Shift_Ins | novel | c.412_413insAGAGAACATT | p.Leu138GlnfsTer29 | p.L138Qfs*29 | Q96T51 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
RUFY1 | insertion | Frame_Shift_Ins | novel | c.415_416insCCAGCACGTATAGATATCTG | p.Asp139AlafsTer19 | p.D139Afs*19 | Q96T51 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |