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Gene: RTL8C |
Gene summary for RTL8C |
Gene summary. |
Gene information | Species | Human | Gene symbol | RTL8C | Gene ID | 8933 |
Gene name | retrotransposon Gag like 8C | |
Gene Alias | CXX1 | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6ZKI3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8933 | RTL8C | HTA11_347_2000001011 | Human | Colorectum | AD | 3.16e-05 | 1.45e-01 | -0.1954 |
8933 | RTL8C | HTA11_411_2000001011 | Human | Colorectum | SER | 1.38e-05 | 5.27e-01 | -0.2602 |
8933 | RTL8C | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.60e-02 | 1.38e-01 | -0.1207 |
8933 | RTL8C | HTA11_83_2000001011 | Human | Colorectum | SER | 1.25e-02 | 1.76e-01 | -0.1526 |
8933 | RTL8C | HTA11_696_2000001011 | Human | Colorectum | AD | 1.10e-03 | 1.67e-01 | -0.1464 |
8933 | RTL8C | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.43e-11 | 3.29e-01 | -0.059 |
8933 | RTL8C | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.53e-02 | 1.72e-01 | -0.1706 |
8933 | RTL8C | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.49e-02 | 2.38e-01 | -0.1462 |
8933 | RTL8C | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.98e-02 | 2.16e-01 | 0.0131 |
8933 | RTL8C | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.06e-07 | 2.23e-01 | 0.0588 |
8933 | RTL8C | LZE2T | Human | Esophagus | ESCC | 5.44e-10 | 6.52e-01 | 0.082 |
8933 | RTL8C | LZE3D | Human | Esophagus | HGIN | 6.21e-05 | 8.48e-01 | 0.0668 |
8933 | RTL8C | LZE4T | Human | Esophagus | ESCC | 1.39e-20 | 5.77e-01 | 0.0811 |
8933 | RTL8C | LZE5T | Human | Esophagus | ESCC | 5.52e-13 | 5.85e-01 | 0.0514 |
8933 | RTL8C | LZE7T | Human | Esophagus | ESCC | 5.22e-35 | 1.58e+00 | 0.0667 |
8933 | RTL8C | LZE8T | Human | Esophagus | ESCC | 1.35e-07 | 2.44e-01 | 0.067 |
8933 | RTL8C | LZE20T | Human | Esophagus | ESCC | 1.65e-20 | 6.10e-01 | 0.0662 |
8933 | RTL8C | LZE21D1 | Human | Esophagus | HGIN | 3.53e-05 | 6.78e-01 | 0.0632 |
8933 | RTL8C | LZE22D1 | Human | Esophagus | HGIN | 1.32e-09 | 5.19e-01 | 0.0595 |
8933 | RTL8C | LZE22T | Human | Esophagus | ESCC | 3.15e-15 | 7.78e-01 | 0.068 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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