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Gene: RTL8B |
Gene summary for RTL8B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RTL8B | Gene ID | 441518 |
| Gene name | retrotransposon Gag like 8B | |
| Gene Alias | CXX1c | |
| Cytomap | Xq26.3 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q17RB0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 441518 | RTL8B | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 6.08e-01 | 0.082 |
| 441518 | RTL8B | LZE4T | Human | Esophagus | ESCC | 5.68e-07 | 2.52e-01 | 0.0811 |
| 441518 | RTL8B | LZE5T | Human | Esophagus | ESCC | 1.57e-03 | 3.36e-01 | 0.0514 |
| 441518 | RTL8B | LZE7T | Human | Esophagus | ESCC | 1.56e-14 | 5.21e-01 | 0.0667 |
| 441518 | RTL8B | LZE20T | Human | Esophagus | ESCC | 1.97e-04 | 1.86e-01 | 0.0662 |
| 441518 | RTL8B | LZE22T | Human | Esophagus | ESCC | 1.28e-07 | 5.85e-01 | 0.068 |
| 441518 | RTL8B | LZE24T | Human | Esophagus | ESCC | 6.51e-29 | 6.49e-01 | 0.0596 |
| 441518 | RTL8B | LZE21T | Human | Esophagus | ESCC | 1.16e-05 | 3.66e-01 | 0.0655 |
| 441518 | RTL8B | LZE6T | Human | Esophagus | ESCC | 3.01e-06 | 2.35e-01 | 0.0845 |
| 441518 | RTL8B | S014 | Human | Liver | HCC | 2.30e-38 | 9.77e-01 | 0.2254 |
| 441518 | RTL8B | S015 | Human | Liver | HCC | 1.42e-29 | 9.12e-01 | 0.2375 |
| 441518 | RTL8B | S016 | Human | Liver | HCC | 1.18e-45 | 1.01e+00 | 0.2243 |
| 441518 | RTL8B | male-WTA | Human | Thyroid | PTC | 1.25e-05 | 1.28e-01 | 0.1037 |
| 441518 | RTL8B | PTC05 | Human | Thyroid | PTC | 2.31e-02 | 1.38e-01 | 0.2065 |
| 441518 | RTL8B | PTC06 | Human | Thyroid | PTC | 6.68e-06 | 1.60e-01 | 0.2057 |
| 441518 | RTL8B | ATC12 | Human | Thyroid | ATC | 2.80e-17 | 3.43e-01 | 0.34 |
| 441518 | RTL8B | ATC13 | Human | Thyroid | ATC | 6.38e-17 | 3.62e-01 | 0.34 |
| 441518 | RTL8B | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 7.46e-01 | 0.34 |
| 441518 | RTL8B | ATC4 | Human | Thyroid | ATC | 3.30e-22 | 4.62e-01 | 0.34 |
| 441518 | RTL8B | ATC5 | Human | Thyroid | ATC | 1.20e-21 | 3.93e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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