|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: RTEL1-TNFRSF6B |
Gene summary for RTEL1-TNFRSF6B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RTEL1-TNFRSF6B | Gene ID | 100533107 |
| Gene name | RTEL1-TNFRSF6B readthrough (NMD candidate) | |
| Gene Alias | RTEL1-TNFRSF6B | |
| Cytomap | 20q13.33 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100533107 | RTEL1-TNFRSF6B | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 6.28e-01 | 0.0875 |
| 100533107 | RTEL1-TNFRSF6B | P2T-E | Human | Esophagus | ESCC | 7.52e-23 | 9.59e-01 | 0.1177 |
| 100533107 | RTEL1-TNFRSF6B | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 3.81e-01 | 0.1323 |
| 100533107 | RTEL1-TNFRSF6B | P5T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.78e-01 | 0.1327 |
| 100533107 | RTEL1-TNFRSF6B | P10T-E | Human | Esophagus | ESCC | 1.78e-03 | 3.02e-01 | 0.116 |
| 100533107 | RTEL1-TNFRSF6B | P11T-E | Human | Esophagus | ESCC | 1.78e-13 | 6.84e-01 | 0.1426 |
| 100533107 | RTEL1-TNFRSF6B | P16T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.51e-01 | 0.1153 |
| 100533107 | RTEL1-TNFRSF6B | P17T-E | Human | Esophagus | ESCC | 2.60e-06 | 9.43e-01 | 0.1278 |
| 100533107 | RTEL1-TNFRSF6B | P19T-E | Human | Esophagus | ESCC | 2.95e-08 | 1.90e+00 | 0.1662 |
| 100533107 | RTEL1-TNFRSF6B | P21T-E | Human | Esophagus | ESCC | 2.02e-06 | 7.74e-01 | 0.1617 |
| 100533107 | RTEL1-TNFRSF6B | P23T-E | Human | Esophagus | ESCC | 4.42e-05 | 4.01e-01 | 0.108 |
| 100533107 | RTEL1-TNFRSF6B | P24T-E | Human | Esophagus | ESCC | 1.85e-18 | 8.17e-01 | 0.1287 |
| 100533107 | RTEL1-TNFRSF6B | P30T-E | Human | Esophagus | ESCC | 1.02e-02 | 7.37e-01 | 0.137 |
| 100533107 | RTEL1-TNFRSF6B | P31T-E | Human | Esophagus | ESCC | 4.24e-18 | 1.31e+00 | 0.1251 |
| 100533107 | RTEL1-TNFRSF6B | P32T-E | Human | Esophagus | ESCC | 5.00e-17 | 5.63e-01 | 0.1666 |
| 100533107 | RTEL1-TNFRSF6B | P36T-E | Human | Esophagus | ESCC | 1.57e-11 | 7.96e-01 | 0.1187 |
| 100533107 | RTEL1-TNFRSF6B | P37T-E | Human | Esophagus | ESCC | 2.47e-11 | 6.56e-01 | 0.1371 |
| 100533107 | RTEL1-TNFRSF6B | P38T-E | Human | Esophagus | ESCC | 1.45e-09 | 1.03e+00 | 0.127 |
| 100533107 | RTEL1-TNFRSF6B | P40T-E | Human | Esophagus | ESCC | 3.78e-08 | 3.45e-01 | 0.109 |
| 100533107 | RTEL1-TNFRSF6B | P42T-E | Human | Esophagus | ESCC | 1.72e-09 | 6.19e-01 | 0.1175 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |